Reducing blood loss in primary knee arthroplasty: A prospective randomised controlled trial of tranexamic acid and fibrin spray

McConnell, Jamie S; Shewale, Sandeep; Munro, Niall; Shah, Kalpesh; Deakin, A.H.; Kinninmonth, A. W. G.

doi:10.1016/j.knee.2011.06.004

Cited by 53 publications

(49 citation statements)

References 20 publications

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“…Out of the 31 studies (Table 2), two were triple-blind [22,23], 20 were double-blind [8,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42], three were single-blind [43][44][45], one study was non-blinded [46], and the blinding was unclear in five of the studies [47][48][49][50][51]. In one study, the randomization was performed by a person/ pharmacist/resident who was not involved in the study or the care of patients [35].…”

Section: Resultsmentioning

confidence: 99%

One step closer to sparing total blood loss and transfusion rate in total knee arthroplasty: a meta-analysis of different methods of tranexamic acid administration

Shemshaki

Nourian²,

Nourian

et al. 2015

Arch Orthop Trauma Surg

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Section: Resultsmentioning

confidence: 99%

One step closer to sparing total blood loss and transfusion rate in total knee arthroplasty: a meta-analysis of different methods of tranexamic acid administration

Shemshaki

Nourian²,

Nourian

et al. 2015

Arch Orthop Trauma Surg

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“…FSs have been shown to be efficacious and safe in 39 reducing blood loss and transfusion requirements without increasing the risk of deep-vein thrombosis (DVT), 40 pulmonary embolism (PE), superficial infection, fever, hematoma or other complications for patients undergoing 41 TKA [7-9]. However, their main disadvantage is their cost: they are more expensive than TXA [15,16].…”

Section: A N U S C R I P Tmentioning

confidence: 99%

“…After screening the 98 titles and abstracts and reading full text, five studies were excluded based on inclusion criteria. Finally, five 99 studies [15, 16,19,20,25] involving 359 patients were eligible for data extraction and meta-analysis (Fig. 1).…”

mentioning

confidence: 99%

Topical fibrin sealant versus intravenous tranexamic acid for reducing blood loss following total knee arthroplasty: A systematic review and meta-analysis

Gao

Sun

et al. 2016

International Journal of Surgery

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Our meta-analysis suggests that intravenous administration of TXA for patients undergoing TKA may reduce blood-transfusion requirements and maintain higher hemoglobin levels compared with topical application of FS in the early postoperative period. There were no significant differences in total calculated blood loss and prevalence of complications between the two groups. However, owing to the variation of included studies, no firm conclusions can be drawn.

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“…4,5 intraoperative and postoperative auto transfusion, hypotensive anesthesia, tissue binding fibrin, use of tourniquet and methods like femoral intramedullary plug, flexion position of the operated knee joint in the first post-operative hours and temporary closure of the drain. [6][7][8][9][10][11][12][13][14] But, there is no standard widely accepted approach. 15 Developing countries like India EPO is a costly, iron supplement is difficult for patients to adapt because of its gastrointestinal side effects.…”

Section: Introductionmentioning

confidence: 99%

Effect of intravenous tranexamic acid on blood loss and blood transfusion in total knee replacement: a prospective, randomized study in Indian population

Kerakkanavar

Venkatesh

et al. 2017

Int J Res Orthop

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Background: Tranexamic acid (TXA) is antifibrinolytic drug which has the property to reduce intraoperative and postoperative bleeding. There are several studies supporting the use of tranexamic acid in total knee replacements (TKR) and few in total hip replacements. Our study was intended to establish the effects of tranexamic acid in minimizing the intra operative and post-operative blood loss in uncomplicated primary total knee replacement.Methods: This was a prospective follow up study conducted in Rajarajeshwari Medical College and Hospital Bangalore, over a period of 14 months from June 2015 to August 2016. A total number of 60 patients who underwent unilateral primary total knee replacement were included for this study. They were randomly divided into 2 groups. Group I patients infused (intravenous) with 20 mg/kg TXA before incision and 3 hours after surgery whereas no TXA was administered in Group II. Total blood loss and transfusion rate were used as outcome. Results: Mean amounts of blood loss were 578 ml in Group 1 and 946 ml in Group 2. There was a decrease in blood loss in TXA groups (p<0.001). Transfusion was required in 6 patients of Group I and 17 patients of Group II (p<0.001). No thromboembolic problem was seen in any patients.Conclusions: Since TXA decrease perioperative blood loss and lessen the need for blood transfusion significantly, without increasing thromboembolic events in TKR. We suggest using intravenous (IV) TXA in TKR.

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Reducing blood loss in primary knee arthroplasty: A prospective randomised controlled trial of tranexamic acid and fibrin spray

Cited by 53 publications

References 20 publications

One step closer to sparing total blood loss and transfusion rate in total knee arthroplasty: a meta-analysis of different methods of tranexamic acid administration

One step closer to sparing total blood loss and transfusion rate in total knee arthroplasty: a meta-analysis of different methods of tranexamic acid administration

Topical fibrin sealant versus intravenous tranexamic acid for reducing blood loss following total knee arthroplasty: A systematic review and meta-analysis

Effect of intravenous tranexamic acid on blood loss and blood transfusion in total knee replacement: a prospective, randomized study in Indian population

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