Reduced white matter integrity and its correlation with clinical symptom in first-episode, treatment-naive generalized anxiety disorder

Wang, Wei; Qian, Shaowen; Liu, Kai; Li, Bo; Li, Min; Xin, Kuolin; Sun, Gang

doi:10.1016/j.bbr.2016.08.017

Cited by 40 publications

(29 citation statements)

References 35 publications

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“…Although based on depression score-differences in healthy participants, our findings are in line with previously reported FA decrease in the SLF and corpus callosum in individuals diagnosed with MDD (LeWinn et al, 2014;Ota et al, 2015;Wu et al, 2011;Zuo et al, 2012), bipolar disorder (Saricicek et al, 2016), generalized anxiety disorder (Wang et al, 2016) and autism spectrum disorders (Fitzgerald et al, 2016). Additionally, subclinical depressive symptoms have been associated with widespread FA decrease in healthy female participants, including corpus callosum and the right anterior cingulum (Hayakawa et al, 2014), and FA decrease in the bilateral uncinate fasciculus in healthy individuals over 70 years of age (McIntosh et al, 2013).…”

Section: Discussionsupporting

confidence: 92%

The NCAM1 gene set is linked to depressive symptoms and their brain structural correlates in healthy individuals

Petrovska

Coynel

Fastenrath

et al. 2017

Journal of Psychiatric Research

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Depressive symptoms exist on a continuum, the far end of which is found in depressive disorders. Utilizing the continuous spectrum of depressive symptoms may therefore contribute to the understanding of the biological underpinnings of depression. Gene set enrichment analysis (GSEA) is an important tool for the identification of gene groups linked to complex traits, and was applied in the present study on genome-wide association study (GWAS) data of depression scores and their brain-level structural correlates in healthy young individuals. On symptom level (i.e. depression scores), robust enrichment was identified for two gene sets: NCAM1 Interactions and Collagen Formation. Depression scores were also associated with decreased fractional anisotropy (FA) - a brain white matter property - within the forceps minor and the left superior temporal longitudinal fasciculus. Within each of these tracts, mean FA value of depression score-associated voxels was used as a phenotype in a subsequent GSEA. The NCAM1 Interactions gene set was significantly enriched in these tracts. By linking the NCAM1 Interactions gene set to depression scores and their structural brain correlates in healthy participants, the current study contributes to the understanding of the molecular underpinnings of depressive symptomatology.

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Section: Discussionsupporting

confidence: 92%

The NCAM1 gene set is linked to depressive symptoms and their brain structural correlates in healthy individuals

Petrovska

Coynel

Fastenrath

et al. 2017

Journal of Psychiatric Research

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“…Although our study findings point to decreased FA in the right dorsal cingulum in young IBS patients compared to matched healthy controls, the pathogenesis underlying these WM changes cannot be discerned from the present data. WM abnormalities in FA and other non-FA metrics in the cingulum have been linked to anxiety disorders such generalized anxiety disorder, obsessive-compulsive disorder and post-traumatic stress disorder ( Lochner et al, 2012 ; Daniels et al, 2013 ; Wang et al, 2016 ), as well a various pain conditions, including complex regional pain syndrome (CRPS), temporomandibular disorder, chronic musculoskeletal pain, trigeminal neuralgia, and IBS ( Geha et al, 2008 ; Chen et al, 2011 ; Moayedi et al, 2012 ; Ellingson et al, 2013 ; DeSouza et al, 2014 ; Lieberman et al, 2014 ; Qi et al, 2016 ). Therefore, it is possible that the observed microstructural WM changes reflect sensitization of viscerosomatic nociceptive afferents, leading to functional reorganization in spinothalamic and corticolimbic tracts involved in processing pain and affect, including the dorsal cingulum bundle.…”

Section: Discussionmentioning

confidence: 99%

Microstructural White Matter Abnormalities in the Dorsal Cingulum of Adolescents with IBS

Hubbard

Becerra

Heinz

et al. 2018

eNeuro

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Alterations in fractional anisotropy (FA) have been considered to reflect microstructural white matter (WM) changes in disease conditions; however, no study to date has examined WM changes using diffusion tensor imaging (DTI) in adolescents with irritable bowel syndrome (IBS). The objective of the present study was two-fold: (1) to determine whether differences in FA, and other non-FA metrics, were present in adolescents with IBS compared to healthy controls using whole-brain, region of interest (ROI)-restricted tract-based spatial statistics (TBSS) and canonical ROI DTI analyses for the cingulum bundle, and (2) to determine whether these metrics were related to clinical measures of disease duration and pain intensity in the IBS group. A total of 16 adolescents with a Rome III diagnosis of IBS (females = 12; mean age = 16.29, age range: 11.96–18.5 years) and 16 age- and gender-matched healthy controls (females = 12; mean age = 16.24; age range: 11.71–20.32 years) participated in this study. Diffusion-weighted images were acquired using a Siemens 3-T Trio Tim Syngo MRI scanner with a 32-channel head coil. The ROI-restricted TBSS and canonical ROI-based DTI analyses revealed that adolescents with IBS showed decreased FA in the right dorsal cingulum bundle compared to controls. No relationship between FA and disease severity measures was found. Microstructural WM alterations in the right dorsal cingulum bundle in adolescents with IBS may reflect a premorbid brain state or the emergence of a disease-driven process that results from complex changes in pain- and affect-related processing via spinothalamic and corticolimbic pathways.

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“…In addition, larger volumes in amygdala ( De Bellis et al, 2000 ; Schienle et al, 2011 ), putamen ( Liao et al, 2013 , 2014a ), and altered gray matter volumes in the thalamus, hippocampus, insula, posterior cingulate, and superior temporal gyrus (STG) in GAD patients were reported in the structure magnetic resonance imaging (sMRI) studies ( De Bellis et al, 2002 ; Strawn et al, 2013 ; Moon and Jeong, 2017 ). Diffusion tensor imaging (DTI) has shown that the GAD patients have increased fractional anisotropy (FA) in the amygdala ( Zhang et al, 2013 ) and postcentral gyrus ( Zhang et al, 2011 ), while reduced FA in bilateral uncinate fasciculus, body of corpus callosum, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, and corona radiate ( Liao et al, 2014b ; Wang et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Aberrant Functional Network Connectivity as a Biomarker of Generalized Anxiety Disorder

Qiao

Cao

et al. 2017

Front. Hum. Neurosci.

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Neural disruptions during emotion regulation are common of generalized anxiety disorder (GAD). Identifying distinct functional and effective connectivity patterns in GAD may provide biomarkers for their diagnoses. This study aims to investigate the differences of features of brain network connectivity between GAD patients and healthy controls (HC), and to assess whether those differences can serve as biomarkers to distinguish GAD from controls. Independent component analysis (ICA) with hierarchical partner matching (HPM-ICA) was conducted on resting-state functional magnetic resonance imaging data collected from 20 GAD patients with medicine-free and 20 matched HC, identifying nine highly reproducible and significantly different functional brain connectivity patterns across diagnostic groups. We then utilized Granger causality (GC) to study the effective connectivity between the regions that identified by HPM-ICA. The linear discriminant analysis was finally used to distinguish GAD from controls with these measures of neural connectivity. The GAD patients showed stronger functional connectivity in amygdala, insula, putamen, thalamus, and posterior cingulate cortex, but weaker in frontal and temporal cortex compared with controls. Besides, the effective connectivity in GAD was decreased from the cortex to amygdala and basal ganglia. Applying the ICA and GC features to the classifier led to a classification accuracy of 87.5%, with a sensitivity of 90.0% and a specificity of 85.0%. These findings suggest that the presence of emotion dysregulation circuits may contribute to the pathophysiology of GAD, and these aberrant brain features may serve as robust brain biomarkers for GAD.

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Reduced white matter integrity and its correlation with clinical symptom in first-episode, treatment-naive generalized anxiety disorder

Cited by 40 publications

References 35 publications

The NCAM1 gene set is linked to depressive symptoms and their brain structural correlates in healthy individuals

The NCAM1 gene set is linked to depressive symptoms and their brain structural correlates in healthy individuals

Microstructural White Matter Abnormalities in the Dorsal Cingulum of Adolescents with IBS

Aberrant Functional Network Connectivity as a Biomarker of Generalized Anxiety Disorder

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