Reduced volume of gray matter in patients with trigeminal neuralgia

Li, Meng; Yan, Ji; Li, Shumei; Wang, Tianyue; Zhan, Wang; Wen, Huaxuan; Ma, Xiaofen; Zhang, Yong; Jian-guo, Tian; Jiang, Guihua

doi:10.1007/s11682-016-9529-2

Cited by 61 publications

(54 citation statements)

References 36 publications

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“…Protracted pain can cause changes in the brain structure (Kuchinad et al, 2007; Li et al, 2016), and the underlying mechanism may be explained by neuronal plasticity (Woolf and Salter, 2000). Our data revealed that the MK values in the right ACC were significantly negatively correlated with pain duration and VAS scores, whereas the AK values in the right mPFC were significantly negatively correlated with the VAS scores.…”

Section: Discussionmentioning

confidence: 99%

“…The brain gray matter is closely associated with the body’s pain perception (Cauda et al, 2014; Emerson et al, 2014). A large body of evidence indicated that the gray matter might exhibit abnormalities under chronic pain status, such as trigeminal neuralgia (Obermann et al, 2013; Li et al, 2016), chronic low back pain (Seminowicz et al, 2011; Fritz et al, 2016), fibromyalgia (Hsu et al, 2009; Robinson et al, 2011), phantom limb pain (Preissler et al, 2013), cyclic menstrual pain (Tu et al, 2010), complex regional pain syndrome (Geha et al, 2008), and migraine (Magon et al, 2015). In addition, the density and volume changes of gray matter in patients with chronic pain are also related to clinical traits (Apkarian et al, 2004; Kuchinad et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Microstructural Abnormalities Were Found in Brain Gray Matter from Patients with Chronic Myofascial Pain

et al. 2016

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Myofascial pain, presented as myofascial trigger points (MTrPs)-related pain, is a common, chronic disease involving skeletal muscle, but its underlying mechanisms have been poorly understood. Previous studies have revealed that chronic pain can induce microstructural abnormalities in the cerebral gray matter. However, it remains unclear whether the brain gray matters of patients with chronic MTrPs-related pain undergo alteration. In this study, we employed the Diffusion Kurtosis Imaging (DKI) technique, which is particularly sensitive to brain microstructural perturbation, to monitor the MTrPs-related microstructural alterations in brain gray matter of patients with chronic pain. Our results revealed that, in comparison with the healthy controls, patients with chronic myofascial pain exhibited microstructural abnormalities in the cerebral gray matter and these lesions were mainly distributed in the limbic system and the brain areas involved in the pain matrix. In addition, we showed that microstructural abnormalities in the right anterior cingulate cortex (ACC) and medial prefrontal cortex (mPFC) had a significant negative correlation with the course of disease and pain intensity. The results of this study demonstrated for the first time that there are microstructural abnormalities in the brain gray matter of patients with MTrPs-related chronic pain. Our findings may provide new insights into the future development of appropriate therapeutic strategies to this disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microstructural Abnormalities Were Found in Brain Gray Matter from Patients with Chronic Myofascial Pain

et al. 2016

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“…Pain was identified as a psychological stress 30 and, vice versa, stress is a factor that causes and maintains pain intensity 29 . Several studies have shown morphological as well as functional changes in both neuralgic 1,3,[5][6][7][8] and stress states [11][12][13][14] . We noticed that latencies at the neuralgic side were shorter as a result of the hyper-excitability of dysfunctional nerves.…”

Section: Discussionmentioning

confidence: 99%

“…Demyelination may give an increase to electrical hyper excitability, spontaneous and triggered ectopic impulses and cross excitation among neighboring afferents 1,3,5 . Atrophy of the trigeminal nerve 6,7 and reduced volume of gray matter 1,8 are also seen.…”

Section: Introductionmentioning

confidence: 99%

Salivary alpha-amylase and tooth pulp evoked potentials in paroxysmal trigeminal neuralgia patients

Vukovic¹,

Lazić

Nikolic³

et al. 2021

VOJNOSANIT PREGL

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Introduction / Aim. The sudden and excruciating pain that characterizes paroxysmal trigeminal neuralgia (PTN) has a negative effect on wellbeing of the affected individuals, causing psychological distress. Salivary alpha amylase (sAA) level represents an objective assessment of physical, physiological and psychological stress. Evoked potentials (EPs) can reflect nerve function and evaluate a functional aspect of the trigeminal nerve conduction. The aim of this study was to analyze possible modifications in painful impulses conduction related to sAA level by registering tooth pulp EP in PTN patients. Methods. Ten PTN patients and twelve healthy subjects participated in the study. Activity of sAA was measured using Nipro Salivary Amylase Monitor. To record EP response, dental pulp of vital teeth was electrically stimulated through intact enamel. For stimulation and impulse registration we used Xltek Protektor 32 system, software EPWorks, version 5.0. Results. The results obtained in PTN patients showed a higher number of waves and significantly shorter latencies and lower amplitudes N2-P2 and N3-P3 at the neuralgic side compared to the healthy side of the same patient, as well as to the controls (p<0.05). Also, latencies were significantly shorter in patients with higher sAA levels than in those with normal sAA levels (p<0.05). Late latencies (N2 and P2) at the healthy side in patients with higher sAA levels were significantly shorter compared to patients whose sAA levels were normal (p<0.05). Conclusion. This study showed that psychical stress associated with PTN probably further increased hyper-excitability and conduction velocity of the affected nerves. Moreover, it seems that anticipation of stressful pain even increases conduction velocity of unaffected nerves at the thalamo-cortical level in PTN patients. However, in healthy individuals, stress itself had no influence on painful impulses conduction.

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“…In several trigeminal neuralgia studies, the reduction of the volume of the anterior cingulate cortex (ACC) and the increase of the volume of the temporal cortex were found. Li et al also considered that the increase in the volume of the upper and middle gyrus was proportional to the duration of trigeminal neuralgia [6,7].…”

Section: Vbmmentioning

confidence: 99%

The Application of Functional Magnetic Resonance Imaging in Neuropathic Pain

Dou¹,

Yang²

2019

Medical Imaging - Principles and Applications [Working Title]

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In the past, neuropathic pain has been lacking in ideal imaging research methods, which not only limits our research on the pathogenesis of neuropathic pain but also seriously affects the prognosis of treatments. With the rapid development of fMRI technology, more and more scholars have begun to use fMRI technology in the study of neuropathic pain in recent years. This provides a new idea for revealing the underlining mechanisms of neuropathic pain and improving the clinical treatment concepts. In this chapter, we summarized the recent studies of fMRI in neuropathic pain so that readers can better understand the research status and future research directions.

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Reduced volume of gray matter in patients with trigeminal neuralgia

Cited by 61 publications

References 36 publications

Microstructural Abnormalities Were Found in Brain Gray Matter from Patients with Chronic Myofascial Pain

Microstructural Abnormalities Were Found in Brain Gray Matter from Patients with Chronic Myofascial Pain

Salivary alpha-amylase and tooth pulp evoked potentials in paroxysmal trigeminal neuralgia patients

The Application of Functional Magnetic Resonance Imaging in Neuropathic Pain

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