Reduced vacuolar ATPase protects mice from Friend virus infection – an unintended but instructive effect in Hif-2afl mice
Timm Schreiber,
Nora Koll,
Claudia Padberg
et al.
Abstract:During acute viral infections, innate immune cells invade inflamed tissues and face hypoxic areas. Hypoxia-inducible factors (HIFs) adapt cellular responses towards these conditions. We wanted to investigate the effects of a loss of HIF-2α in macrophages during acute Friend murine leukemia retrovirus (FV) infection in C57BL/6 mice using a Cre/loxP system. Remarkably, mice with floxed Hif-2a (Hif-2afl; Hif-2a is also known as Epas1) did not show any signs of FV infection independent of Cre activity. This preven… Show more
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