Reduced thirst in patients with a vasospastic syndrome

Abstract

ABSTRACT.Purpose: To compare thirst, drinking behaviour, and endothelin-1 (ET-1) plasma levels between vasospastic and non-vasospastic subjects. Methods: We compared 67 subjects with a primary vasospastic syndrome with 64 age-and sex-matched non-vasospastic control subjects. A detailed medical history was recorded, including a questionnaire containing queries about thirst and drinking behaviour, history of migraine or unspecific headache, history of episodes of low blood pressure, and smoking habits. Body mass index (BMI) was calculated and blood samples were drawn for ET-1 measurements. Results: Subjects with a vasospastic syndrome reported a reduced desire to drink and a lower estimated quantity of daily fluid intake, more often forgot to drink, more often had both migraine and unspecific headache, more often had episodes of low blood pressure, and had an increased plasma level of ET-1. These features differed statistically significantly between the two groups. There was also a nonsignificant trend among vasospastic subjects to smoke less and to have a smaller BMI. Conclusion: A reduced desire to drink is found frequently among vasospastic subjects.

Retinal venous pressure measurements in patients with Flammer syndrome and metabolic syndrome

“…This finding is in line with reports from other authors reporting spontaneous venous pulsations to be present in approximately 76-98% of the population [16,[24][25][26][27]. The reason why the retinal vein spontaneously [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] 19.57 ± 5.93 27.5 ± 8.30 15.98 ± 4.53 17.37 ± 5.49 [10- pulsates remains controversial. A recent analysis attributed it to be due to the difference between IOP and cerebrospinal fluid (CSF) pulsations [16].…”

“…; (2) Do you have trouble falling asleep, especially when you are cold [20]? ; (3) Are you seldom thirsty, and do you have to remind yourself to drink enough [21]? ; (4) Do you suffer from migraine attacks [22]?…”

Rigidity of Retinal Vessel in Untreated Eyes of Normal Tension Primary Open-angle Glaucoma Patients

“…[18][19][20] It was suggested that in the 3 cohorts, a higher level of endothelin-1 could have led to increased retinal vessel rigidity. Indeed, in vasospastic subjects 21 and in patients with multiple sclerosis, increased plasma endothelin-1 levels were observed. 22,23 Moreover, increased levels of endothelin-1 in plasma of NTG patients have also been reported.…”

Hydration and Disease

“…In patients with low-tension glaucoma and visual field defects, emotional stress or cooling one hand in cold water may lead to ocular vasospasms with low blood pressure and increased eye sensitivity to intraocular pressure [74]. In a case control study, subjects with vasospastic syndrome reported a reduced desire to drink, a lower estimated quantity of daily fluid intake, and more episodes of low blood pressure (category III evidence) [75].…”