Reduced thermoregulatory null zone in postmenopausal women with hot flashes

Freedman, Robert R.; Krell, Willane S.

doi:10.1016/s0002-9378(99)70437-0

Cited by 261 publications

(177 citation statements)

References 10 publications

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“…Więk-szość kobiet zgłaszających się do ginekologa w okresie okołomenopauzalnym podaje uderzenia gorąca i/lub nadmierne pocenie się jako najbardziej dokuczliwy objaw, który jest jednocześnie głównym powodem ich wizyty u lekarza. Etiopatogeneza uderzeń gorąca jest ściśle związana z nagłym zmniejszeniem stężenia estrogenów, w wyniku czego dochodzi do zaburzeń regulacji neurotransmiterów i neuromodulatorów (serotoniny, dopaminy, noradrenaliny, endorfiny) i na skutek tego prowadzi do zaburzeń ośrodka termoregulacji w podwzgórzu oraz zaburzeń równowagi w autonomicznym układzie nerwowym [10][11][12].…”

Section: Wstępunclassified

Is acupuncture effective in treatment of hot flashes?

Woźniak¹,

Ziółkowski²,

Stetkiewicz³

et al. 2012

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StreszczenieMenopauza jest kolejnym etapem życia kobiety, w którym bardzo często dochodzi do obniżenia jakości życia ze względu na występowanie wielu schorzeń i objawów, m.in. objawów wypadowych typu uderzenia gorąca. Uderzenia gorąca i nadmierne pocenie się, będące ich nocnym odpowiednikiem, występują w okresie okołome-nopauzalnym u większości kobiet. Jednocześnie są najczęstszym powodem zgłaszania się pacjentek w okresie okołomenopauzalnym do ginekologa. Podstawowym sposobem terapii tych zaburzeń jest stosowanie menopauzalnej terapii hormonalnej (menopausal hormone therapy -MHT).Jednak nie wszystkie kobiety mogą stosować MHT, a część z nich dodatkowo obawia się terapii hormonalnej. Ta grupa pacjentek szuka alternatywnego sposobu złagodzenia objawów klimakterycznych. Jedną z tych metod jest akupunktura, która w ostatnim dziesięcioleciu znalazła uznanie jako metoda bezpieczna i skuteczna. Autorzy przeprowadzili retrospektywne badanie grupy 86 pacjentek w okresie okołomenopauzalnym, niestosujących MHT, z nasilonymi objawami naczynioruchowymi, które poddały się w latach 2010-2011 zabiegom akupunktury. Badanie to miało odpowiedzieć na pytanie o skuteczność akupunktury w leczeniu uderzeń gorąca.Słowa kluczowe: akupunktura, menopauza, uderzenia gorąca. SummaryThe menopause is a successive stage of the woman's life, during which the quality of her life decreases very frequently due to the occurrence of many diseases and symptoms, among others, the perimenopausal symptoms such as hot flashes. Hot flashes and hidrosis as their night equivalent, appear during the perimenopausal period in the majority of women. At the same time, they are the most frequent reason of women patients in the perimenopausal period, for seeing the gynaecologist. The basic therapeutic method used in treatment of the above mentioned disorders is the menopausal hormone therapy (MHT).Nevertheless, not every woman can apply the MHT, and some women are also afraid of using any hormone therapy. Namely, this group of women is looking for an alternative way to relieve symptoms of the climacteric. One of these methods is acupuncture, which gained a recognition within the last decade as a safe and effective method. The authors conducted a retrospective study with a group of 86 women patients in the perimenopausal period with the exacerbated vasomotor symptoms, who were not applying any MHT, but who underwent acupuncture treatment in 2010-2011. The study was to answer a question about effectiveness of acupuncture in treatment of hot flashes.

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Section: Wstępunclassified

Is acupuncture effective in treatment of hot flashes?

Woźniak¹,

Ziółkowski²,

Stetkiewicz³

et al. 2012

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“…These same investigators subsequently found that postmenopausal women with hot flushes had a narrower thermoregulatory zone (0°C) compared with postmenopausal women who do not flush (0.4°C). This narrowing was mainly due to a lowering of the sweating threshold in symptomatic women (6). Since heat loss mechanisms can be triggered by a 0.01 o elevation of core body temperature above the regulatory zone, the subtle changes in temperature before a hot flush, coupled with a narrow homeostatic temperature zone, may trigger the heat loss mechanisms that lead to hot flush symptoms.…”

Section: Introductionmentioning

confidence: 98%

“…Norepinephrine is thought to be the primary neurotransmitter responsible for lowering the thermoregulatory set point and triggering hot flushes (6)(7). Animal studies have shown that intrahypothalamic injection of norepinephrine acts to narrow the thermoregulatory zone (8).…”

Section: Introductionmentioning

confidence: 99%

Hot flushes, vascular reactivity and the role of the α-adrenergic system

et al. 2012

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“…Hot flushes are associated with declining levels of oestrogen [11], purportedly because a decline in this hormone is associated with a narrowing of the thermoneutral zone between the core body temperatures that trigger shivering and sweating [12]. When the sweating threshold is lowered by hormonal changes, women sweat more easily in response to increases in core body temperature [13].…”

Section: Introductionmentioning

confidence: 99%

Hot flushes and reproductive hormone levels during the menopausal transition

et al. 2016

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(2016) 'Hot ushes and reproductive hormone levels during the menopausal transition. ', Maturitas., Further information on publisher's website: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details.

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Reduced thermoregulatory null zone in postmenopausal women with hot flashes

Cited by 261 publications

References 10 publications

Is acupuncture effective in treatment of hot flashes?

Is acupuncture effective in treatment of hot flashes?

Hot flushes, vascular reactivity and the role of the α-adrenergic system

Hot flushes and reproductive hormone levels during the menopausal transition

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