Reduced temporal lobe areas in schizophrenia: Preliminary evidences from a controlled multiplanar magnetic resonance imaging study

Rossi, Alessandro; Stratta, Paolo; D'Albenzio, L.; Tartaro, Armando; Schiazza, G.; Michele, Vittorio Di; Bolino, Francesca; Casacchia, M

doi:10.1016/0006-3223(90)90020-3

Cited by 100 publications

(29 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have found reductions in the total temporal lobe volume more marked on the left side (Coffman et al 1989;Johnstone et al 1989;Rossi et al 1990;DeLisi et al 1991), while others report bilateral and equal reductions in total temporal lobe volume (DeLisi et al 1988;Suddath et al 1989;Dauphinais et al 1990). We found that volume reduction was particularly marked in the right temporal lobe, similar to Bogerts et al (19906) but clearly against the trend of most studies and the reason for this discrepancy is not immediately clear.…”

Section: Discussionmentioning

confidence: 95%

Reduction of cortical volume in schizophrenia on magnetic resonance imaging

et al. 1993

View full text Add to dashboard Cite

SYNOPSIS The MRI scans of 48 schizophrenic patients, fulfilling RDC criteria, were compared to those of 34 healthy controls matched for age, ethnicity and parental social class. The volume of the frontal and anterior parietal lobes was significantly reduced in the schizophrenic group as a result of a selective decrease in cortical volume, with a corresponding increase in the volume of sulcal fluid. Reduction in the volume of the temporal grey matter was more marked on the right, but was not in excess of the loss of volume observed in other areas of the cortex. MRI abnormalities correlated poorly with clinical parameters, although both unemployment and poor pre-morbid adjustment predicted reduced cerebral volume and increased sulcal volume. These results question whether the medial temporal lobes are the only site of structural pathology in schizophrenia.

show abstract

Section: Discussionmentioning

confidence: 95%

Reduction of cortical volume in schizophrenia on magnetic resonance imaging

et al. 1993

View full text Add to dashboard Cite

show abstract

“…Several structural abnormalities appear to be integral to the disease process itself, including the enlargement of the lateral and third ventricles (Shenton et al 1997;McCarley et al 1999) as well as volumetric reductions in temporal cortex (Suddath et al 1989;Rossi et al 1990;DeLisi et al 1991), hippocampus (Bogerts et al 1985(Bogerts et al , 1990Suddath et al 1990), superior temporal gyrus (Barta et al 1990;Shenton et al 1992) and thalamus (Andreasen et al 1994). Other anatomic abnormalities in schizophrenia, however, appear to develop secondarily to the disease process.…”

mentioning

confidence: 99%

Striatal Volume Changes in the Rat Following Long-term Administration of Typical and Atypical Antipsychotic Drugs

Andersson

2002

Neuropsychopharmacology

102

View full text Add to dashboard Cite

Caudate-putamen; Basal ganglia; Haloperidol; Clozapine; Olanzapine; Risperidone; Stereology In the last three decades, there has been a notable elucidation concerning the structure, organization and function of the basal ganglia, as well as the clinical relevance of this subcortical structure. The basal ganglia are comprised of four major structures: the striatum (made up of the caudate nucleus, the putamen, and the ventral striatum), the globus pallidus, the substantia nigra, and the subthalamic nucleus. The striatum receives inputs from the neocortex and the substantia nigra and, via the globus pallidus and substantia nigra, modulates thalamic function that, in turn, affects the frontal cortex. Although the role of the basal ganglia in movement planning and execution has been recognized for many years, we now understand that the compartmentalization and diverse chemoarchitecture of the basal ganglia, combined with complex anatomical interrelationships with thalamus and cortex, establishes this structure as a prime component in influencing executive function, emotion, and cognitive behaviors including learning and memory (Alexander et al. 1990). These findings also help explain why lesions of the basal ganglia lead to devastating movement disorders such as Parkinson's and Huntington's disease. Furthermore, due to both the complexity and functional parameters of this structure, the basal ganglia may play an important role in a number of neuropsychiatric disorders such as schizophrenia (Albin et al. 1989).Sensitive structural and functional brain imaging techniques have begun to unravel some of the complicated neuropathology present in schizophrenia. Several structural abnormalities appear to be integral to the disease process itself, including the enlargement of the lateral and third ventricles (Shenton et al. 1997;McCarley et al. 1999) as well as volumetric reductions in temporal cortex (Suddath et al. 1989;Rossi et al. 1990;DeLisi et al. 1991), hippocampus (Bogerts et al. 1985(Bogerts et al. , 1990Suddath et al. 1990), superior temporal gyrus (Barta et al. 1990;Shenton et al. 1992) and thalamus (Andreasen et al. 1994). Other anatomic abnormalities in schizophrenia, however, appear to develop secondarily to the disease process. Postmortem studies and early in vivo imaging studies have reported volumetric increases of the caudate-putamen complex in schizophrenic patients (Heckers et al. 1991;Jernigan et al. 1991). Although initially believed to be a result of a pathological neurodevelopmental process affecting the basal ganglia (Swayze et al. 1992), these structural abnormalities now appear to be probable treatment effects. In a study examining first-episode, treatment-naïve schizophrenia patients, Chakos et al. (1994) demonstrated that the volume of the caudate nucleus increased after an 18-month exposure to typical antipsychotic drugs in direct proportion to the extent of treatment, findings later confirmed by Keshavan et al. (1994). In addition, Doraiswamy et al. (1995) reported that volumetric increase...

show abstract

“…Schizophrenia has been hypothesized to exhibit an abnormal neurodevelopmental process, which results in reduced brain lobe surface area (e.g., left temporal lobe) [40], [41] and abnormal asymmetry patterns of cortical and subcortical structures [42], [43]. This altered brain lobe surface area and asymmetry patterns in schizophrenic patients may be an endophenotype related to schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Cortical Surface Area Correlates with STON2 Gene Ser307Pro Polymorphism in First-Episode Treatment-Naïve Patients with Schizophrenia

Xiang

Wang

et al. 2013

PLoS ONE

View full text Add to dashboard Cite

BackgroundEvidence shows that STON2 gene is associated with synaptic function and schizophrenia. This study aims to explore the relationship between two functional polymorphisms (Ser307Pro and Ala851Ser) of STON2 gene and the cortical surface area in first-episode treatment-naïve patients with schizophrenia and healthy controls.Methodology/Principal FindingsMagnetic resonance imaging of the whole cortical surface area, which was computed by an automated surface-based technique (FreeSurfer), was obtained from 74 first-episode treatment-naïve patients with schizophrenia and 55 healthy controls. Multiple regression analysis was performed to investigate the effect of genotype subgroups on the cortical surface area. A significant genotype-by-diagnosis effect on the cortical surface area was observed. Pro-allele carriers of Ser307Pro polymorphism had larger right inferior temporal surface area than Ser/Ser carriers in the patients with schizophrenia; however, no significant difference was found in the same area in the healthy controls. The Ala851Ser polymorphism of STON2 gene was not significantly associated with the cortical surface area in patients with schizophrenia and healthy controls.Conclusions/SignificanceThe present study demonstrated that the functional variant of the STON2 gene could alter cortical surface area on the right inferior temporal and contribute to the pathogenesis of schizophrenia.

show abstract

Reduced temporal lobe areas in schizophrenia: Preliminary evidences from a controlled multiplanar magnetic resonance imaging study

Cited by 100 publications

References 20 publications

Reduction of cortical volume in schizophrenia on magnetic resonance imaging

Reduction of cortical volume in schizophrenia on magnetic resonance imaging

Striatal Volume Changes in the Rat Following Long-term Administration of Typical and Atypical Antipsychotic Drugs

Cortical Surface Area Correlates with STON2 Gene Ser307Pro Polymorphism in First-Episode Treatment-Naïve Patients with Schizophrenia

Contact Info

Product

Resources

About