Reduced temporal lobe areas in schizophrenia: Preliminary evidences from a controlled multiplanar magnetic resonance study

Rossi, Andiara De; Stratta, Paolo; D'Albenzio, L.; Tartaro, Armando; Schiazza, G.; DiMichele, V; Bolino, Francesca; Casacchia, M

doi:10.1016/0920-9964(90)90081-h

Cited by 6 publications

(4 citation statements)

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“…The data from AEG have not been assessed from this point of view. Among CT scan studies, significant diagnosis × side interactions were present in the MZ twin study of Reveley et al (1987), and among MRI studies, in those of Johnstone et al (1989 b ) and Rossi et al (1990 a , 1990 b ). In addition, in the study of Coffman et al (1989), right-left difference scores for the temporal lobe area were significantly ( p < 0.02) greater in schizophrenic patients than in control subjects.…”

Section: Are There Significant Diagnosis × Hemisphere Interactions?mentioning

confidence: 88%

“…With respect to temporal lobe area, Johnstone et al (1989 b ) found a relative reduction (with a diagnosis × side interaction) on the left in patients with schizophrenia by comparison with those with affective disorders and age-matched control subjects. Rossi et al (1990 a , 1990 b ) found significant reductions in temporal lobe area on the left but not on the right side in young patients (mean age of onset = 22 years) compared to normal control subjects. Coffman et al (1989) observed a reduction in temporal lobe size, significantly greater on the left than on the right side, in their group of schizophrenic patients by comparison with normal control subjects, and DeLisi et al (1990) reported similar findings in a group of patients with chronic (but not in those with acute) schizophrenia.…”

Section: Asymmetries Of Brain Structure In Schizophreniamentioning

confidence: 96%

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Temporal Lobe Asymmetries as the Key to the Etiology of Schizophrenia

Crow¹

1990

Schizophrenia Bulletin

373

146

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With evidence that determinants of psychosis are present early and influence brain development, and in the absence of a significant environmental contribution, schizophrenia may be regarded as a genetic encephalopathy. Morphological abnormalities are particularly apparent in the temporal lobe and on the left side of the brain, and in a number of studies significant diagnosis x side interactions have been detected. Such interactions suggest an intimate relationship between the disease process and the mechanisms that determine asymmetrical brain development. These mechanisms presumably relate to the human capacity for speech and communication, and they may have played a critical role in the evolution of the human brain. A candidate locus for an asymmetry determinant and the psychosis gene within the exchange region of the sex chromosomes is proposed. Some sex differences in schizophrenia (e.g., with respect to age of onset and brain structure) may relate to subtle differences in the rate of asymmetry development in the two sexes.

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Section: Are There Significant Diagnosis × Hemisphere Interactions?mentioning

confidence: 88%

Section: Asymmetries Of Brain Structure In Schizophreniamentioning

confidence: 96%

Temporal Lobe Asymmetries as the Key to the Etiology of Schizophrenia

Crow¹

1990

Schizophrenia Bulletin

373

146

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“…There was no asymmetry in the temporal lobe. Structural MRI studies have reported lateralized changes in the temporal lobes, such as a reduction of the left temporal lobe (DeLisi et al 1990; Rossi et al 1990). Indeed, these studies were focused on the planum temporale, while the VOI in our study was centered on the hippocampus.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, these studies were focused on the planum temporale, while the VOI in our study was centered on the hippocampus. The planum temporale is well known to be asymmetric in healthy subjects, and a large study of literature has reported a reduction or a reverse asymmetry of this structure in schizophrenia patients (Rossi et al 1990). In consequence, the absence of asymmetry in metabolite ratios in our study was probably due to a difference of localization of the VOI.…”

Section: Discussionmentioning

confidence: 99%

Proton Magnetic Resonance Spectroscopy (1H MRS) in Schizophrenia: Investigation of the Right and Left Hippocampus, Thalamus, and Prefrontal Cortex

Delamillieure

Constans²,

Fernández

et al. 2002

Schizophrenia Bulletin

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Single voxel proton magnetic resonance spectroscopy (1H MRS) was used to study the metabolites N-acetylaspartate (NAA), choline (CHO), and myo-inositol (ml) in order to test a neurodegenerative hypothesis in schizophrenia (decrease of NAA, increase of CHO, and increase of ml) and a cerebral asymmetry of these metabolites. 1H MRS was performed in 17 schizophrenia patients and 14 healthy subjects in three cerebral areas highly involved in the pathophysiology of schizophrenia (the prefrontal cortex, the thalamus, and the hippocampus). The ratio amplitudes between metabolites and creatine plus phosphocreatine (Cr) were determined. No difference in the metabolites existed between patients and healthy subjects. However, relationships were noted between NAA/Cr and age in the thalami of the schizophrenia patients (r = -0.37; p = 0.14) and healthy subjects (r = -0.52; p = 0.05). A significant correlation was observed between NAA/Cr and age of onset of illness in the hippocampi of schizophrenia patients (r = -0.59; p < 0.05). Moreover, NAA/Cr was lower in the right than in the left prefrontal cortex in both schizophrenia patients and healthy subjects. There was no relationship between the metabolites and duration of illness or dose of antipsychotics. These findings might suggest a neurodegenerative process in the hippocampi of schizophrenia patients with late onset of illness, and the NAA/Cr ratio could be a marker of aging in the thalami.

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