Reduced temporal lobe area in schizophrenia by magnetic resonance imaging: Preliminary evidence

Rossi, Alessandro; Stratta, Paolo; D'Albenzio, L.; Tartaro, Armando; Schiazza, G.; Michele, Vittorio Di; Ceccoli, S.; Casacchia, M

doi:10.1016/0165-1781(89)90056-5

Cited by 17 publications

(3 citation statements)

References 9 publications

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“…The effect of anatomical reduction in the size of the frontal lobe, basal ganglia, or temporal lobe on PET results will have to be considered. While changes in the size of the frontal lobe and basal ganglia are uncertain, decreases in the temporal lobe have been widely reported (see Rossi et al 1989; Bogerts et al 1990; Crow 1990, this issue). Enlargement of the temporal horn might affect medial measurements but would be less likely to affect the lateral surface metabolic rate.…”

Section: Methodological Issuesmentioning

confidence: 98%

The Frontal Lobes, Basal Ganglia, and Temporal Lobes as Sites for Schizophrenia

Buchsbaum¹

1990

Schizophrenia Bulletin

279

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Positron emission tomography studies with fluorodeoxyglucose in patients with schizophrenia are reviewed and findings in the frontal lobes, basal ganglia, and temporal lobes summarized from more than 20 published studies. Despite methodological and clinical population differences between studies, most reports indicate that patients with schizophrenia are more likely to be low in these areas than in the occipital lobe, cerebellum, or in white matter. This is consistent with blood flow and some neuroanatomical findings. Cluster analysis on our own sample suggests that patients may be low in all three areas rather than a pattern of three distinct clusters. Further study of individual symptom differences, medication effects, and of psychophysical tasks salient for these brain areas is indicated.

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Section: Methodological Issuesmentioning

confidence: 98%

The Frontal Lobes, Basal Ganglia, and Temporal Lobes as Sites for Schizophrenia

Buchsbaum¹

1990

Schizophrenia Bulletin

279

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“…Previous studies (not necessarily with patients showing a history of hallucinations) have shown d i m i n i s h e d left temporal lobe perfusion in schizophrenics 155, 62,63). Few SPECT studies have explicitly examined regional activity in subjects experiencing hallucinations and little consistency has been found among these studies.…”

Section: Discussionmentioning

confidence: 96%

Single Photon Emission Computed Tomography (SPECT) Measures of Brain Function in Schizophrenia

Gordon

Barry

Anderson

et al. 1994

Aust N Z J Psychiatry

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This study explores SPECT measured in schizophrenic patients at rest. Left temporal lobe activity was found to be decreased with increasing positive symptoms' scores scores. Medicated patients showed a reversal of this pattern underlying this positive symptom effect. Patients with a recent history of auditory hallucinations showed an atypical right temporal lobe dominance, which occurred independently of medication status. These preliminary data are suggestive of the potential utility of SPECT to elucidate symptom/medication/brain activity interrelationships in schizophrenia.

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“…Recent magnetic resonance imaging (MRI) studies of putative regional cerebral pathology in schizophrenia appear to converge on the finding of tissue loss in temporal limbic structures (Barta, Pearlson, Powers, Richards, & Tune, 1990; Bogerts et al, 1990; DeLisi et al, 1988; Jernigan et al, 1991; Johnstone et al, 1989; Rossi et al, 1989; Suddath et al, 1989, 1990; Young et al, 1991). The CT findings of frontal lobe dysmorphology have been difficult to replicate with MRI (e.g., Andreasen et al, 1990; DeLisi et al, 1991; Kelsoe, Cadet, Pickar, & Weinberger, 1988; Rossi et al, 1990; Suddath et al, 1989; Uematsu & Kaiya, 1989).…”

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confidence: 99%

Structural cerebral pathology in schizophrenia: Regional or diffuse?

Raz¹

1993

Journal of Abnormal Psychology

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Is brain pathology in schizophrenia topographically distinct? If so, are the putative regional changes unique to the disorder? To address these questions, 56 chronic schizophrenic Ss were compared with 16 psychiatric control Ss with mood disorders and with 31 healthy volunteers on multiple-volume measures of regional cerebral atrophy obtained with computed tomography. Generalized cortical and subcortical enlargement of spaces filled with cerebrospinal fluid sparing only the occipitoparietal cortex was found in the schizophrenic Ss compared with normal control Ss. Statistically significant differences in the extent of perisylvian atrophy were noted between schizophrenic Ss and patients with mood disorders: Schizophrenic Ss evidenced greater dilation of perisylvian fissures and sulci. The implications of the results for future research and for recent theories on the etiology of schizophrenia are discussed.

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Reduced temporal lobe area in schizophrenia by magnetic resonance imaging: Preliminary evidence

Cited by 17 publications

References 9 publications

The Frontal Lobes, Basal Ganglia, and Temporal Lobes as Sites for Schizophrenia

The Frontal Lobes, Basal Ganglia, and Temporal Lobes as Sites for Schizophrenia

Single Photon Emission Computed Tomography (SPECT) Measures of Brain Function in Schizophrenia

Structural cerebral pathology in schizophrenia: Regional or diffuse?

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