Reduced Task-Related Suppression During Semantic Repetition Priming in Schizophrenia

Jeong, Bumseok; Kubicki, Marek

doi:10.1016/j.schres.2010.02.363

Cited by 10 publications

(12 citation statements)

References 21 publications

(29 reference statements)

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“…The activation pattern (low-frequency fluctuations) within all the elements of this network seem to strongly correlate with each other, and network as a whole has been associated with spontaneous and task independent, internally generated thought processes (Fox et al, 2005). It is further believed that the activation within this network is actively suppressed during the cognitive tasks, and that the degree of this suppression correlates with task performance (semantic recognition and semantic priming) (Jeong and Kubicki, 2010). In schizophrenia, few similar observations have been made in relationship to the task performance, i.e.…”

Section: Discussionmentioning

confidence: 99%

“…In schizophrenia, few similar observations have been made in relationship to the task performance, i.e. Whitfield-Gabrieli et al, (2009) report anticorrelations between default-mode network and working memory performance, while Jeong and Kubicki (2010) report anticorrelations between default-mode network and semantic processes in schizophrenia. Both those studies suggest that the decreased activation and poorer cognitive performance in schizophrenia might be partially related to increased activation/decreased suppression within the default-mode network.…”

Section: Discussionmentioning

confidence: 99%

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Whole brain resting state functional connectivity abnormalities in schizophrenia

Venkataraman

Whitford

Westin

et al. 2012

Schizophrenia Research

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137

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Background Schizophrenia has been associated with disturbances in brain connectivity, however the exact nature of these disturbances is not fully understood. Measuring temporal correlations between the activities of spatially disparate brain regions obtained during rest with functional MRI has recently emerged as a popular paradigm for estimating brain connectivity. Previous functional resting state studies in schizophrenia explored either connections related to particular clinical or cognitive symptoms (connectivity within a-priori selected networks), or connections constrained to functional networks obtained from resting state analysis. Relatively less has been done to understand global brain connectivity in schizophrenia. Methods Eighteen patients with chronic schizophrenia and 18 healthy volunteers underwent a resting state fMRI scan on a 3T magnet. Whole brain temporal correlations have been estimated using resting-state fMRI data and free surfer cortical parcellation, and multivariate classification method was then used to indentify brain connections that distinguish schizophrenia patients and healthy controls. Results The classification procedure achieved a prediction accuracy of 75% in differentiating between groups on the basis of their functional connectivity. Relative to controls, schizophrenia patients exhibited co-existing patterns of increased connectivity between parietal and frontal regions, and decreased connectivity between parietal and temporal regions, and between the temporal cortices bilaterally. The decreased parieto-temporal connectivity was associated with the severity of patients’ positive symptoms, while increased fronto-parietal connectivity was associated with patients’ negative and general symptoms. Discussion Our analysis revealed two co-existing patterns of functional connectivity abnormalities in schizophrenia, each related to different clinical profile. Such results provide further evidence that abnormalities in brain connectivity, characteristic of schizophrenia, are directly related to the clinical features of the disorder.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Whole brain resting state functional connectivity abnormalities in schizophrenia

Venkataraman

Whitford

Westin

et al. 2012

Schizophrenia Research

Self Cite

137

View full text Add to dashboard Cite

show abstract

“…Neuroimaging studies have consistently found hyperactivation (i.e., reduced task suppression) of the DMN in patients with schizophrenia during a broad range of cognitive tasks, including the auditory oddball task (Garrity et al 2007), working memory tasks (Meyer-Lindenberg et al 2005, PomarolClotet et al 2008, Whitfield-Gabrieli et al 2009), and language (semantic priming) tasks ( Jeong & Kubicki 2010). Furthermore, when working memory demands are parametrically increased, healthy people exhibit greater suppression of the DMN during working memory tasks, but patients fail to exhibit this pattern (Meyer-Lindenberg et al 2005, Pomarol-Clotet et al 2008, Whitfield-Gabrieli et al 2009).…”

Section: Dmn Activation or Task Suppressionmentioning

confidence: 99%

Default Mode Network Activity and Connectivity in Psychopathology

Whitfield-Gabrieli

Ford

2012

Annu. Rev. Clin. Psychol.

1,217

898

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Neuropsychiatric disorders are associated with abnormal function of the default mode network (DMN), a distributed network of brain regions more active during rest than during performance of many attention-demanding tasks and characterized by a high degree of functional connectivity (i.e., temporal correlations between brain regions). Functional magnetic resonance imaging studies have revealed that the DMN in the healthy brain is associated with stimulus-independent thought and self-reflection and that greater suppression of the DMN is associated with better performance on attention-demanding tasks. In schizophrenia and depression, the DMN is often found to be hyperactivated and hyperconnected. In schizophrenia this may relate to overly intensive self-reference and impairments in attention and working memory. In depression, DMN hyperactivity may be related to negative rumination. These findings are considered in terms of what is known about psychological functions supported by the DMN, and alteration of the DMN in other neuropsychiatric disorders.

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“…Task-related network deficits have been associated with schizophrenia [13], and there is also evidence of abnormal default mode network [14]. Additionally, in schizophrenia, the relationship between inefficient default mode suppression and impairments in task-specific networks, such as language [15], attention and working memory [16], have been demonstrated. Although fMRI demonstrates lack of efficient communication within-brain and between-brain networks in schizophrenia, the underlying anatomical correlates of these abnormalities remain unknown.…”

Section: Key Pointsmentioning

confidence: 99%

Review of functional and anatomical brain connectivity findings in schizophrenia

Fitzsimmons

Kubicki

Shenton

2013

Current Opinion in Psychiatry

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262

165

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Reduced Task-Related Suppression During Semantic Repetition Priming in Schizophrenia

Cited by 10 publications

References 21 publications

Whole brain resting state functional connectivity abnormalities in schizophrenia

Whole brain resting state functional connectivity abnormalities in schizophrenia

Default Mode Network Activity and Connectivity in Psychopathology

Review of functional and anatomical brain connectivity findings in schizophrenia

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