Reduced swim performance and aerobic capacity in adult zebrafish exposed to waterborne selenite

Massé, Anita J.; Thomas, Jith K.; Janz, David M.

doi:10.1016/j.cbpc.2012.12.004

Cited by 24 publications

(24 citation statements)

References 19 publications

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“…Oxygen consumption rate measurements (O 2 mg/kg/hr) were taken every 10 min. consisting of a 240 s flush period in which water was renewed in the swim tunnel with a flush pump, then turned off to create a closed system during a 60s wait period, and a 300s measure period, as described in Masse (Masse et al , 2013). The zebrafish were given a 30 min acclimation period followed by a 20 min free swim at a water flow of 5 cm/sec before swimming against a water current of 10, 20, 30 and 40 cm/sec.…”

Section: Methodsmentioning

confidence: 99%

“…Rapid development, large clutch sizes and short generation time make it ideal for generational studies (Sipes et al , 2011; Baker et al , 2014; Corrales et al , 2014b). One can also assess cardiorespiratory function in juvenile and adult zebrafish with a swim tunnel respirometer to identify treatment effects on fitness (Thomas and Janz, 2011; Masse et al , 2013; Gerger et al , 2015). Early stage zebrafish exhibit a highly reproducible larval photomotor response (LPR) behavior of higher swim activity in the dark than the light.…”

Section: Introductionmentioning

confidence: 99%

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Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish

Knecht

Truong

Marvel

et al. 2017

Toxicology and Applied Pharmacology

116

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Benzo[a]pyrene (B[a]P) is a well-known genotoxic polycylic aromatic compound whose toxicity is dependent on signaling via the aryl hydrocarbon receptor (AHR). It is unclear to what extent detrimental effects of B[a]P exposures might impact future generations and whether transgenerational effects might be AHR-dependent. This study examined the effects of developmental B[a]P exposure on 3 generations of zebrafish. Zebrafish embryos were exposed from 6 – 120 hours post fertilization (hpf) to 5 and 10 μM B[a]P and raised in chemical- free water until adulthood (F0). Two generations were raised from F0 fish to evaluate transgenerational inheritance. Morphological, physiological and neurobehavioral parameters were measured at two life stages. Juveniles of the F0 and F2 exhibited hyper locomotor activity, decreased heartbeat and mitochondrial function. B[a]P exposure during development resulted in decreased global DNA methylation levels and generally reduced expression of DNA methyltransferases in wild type zebrafish, with the latter effect largely reversed in an AHR2-null background. Adults from the F0 B[a]P exposed lineage displayed social anxiety-like behavior. Adults in the F2 transgeneration manifested gender-specific increased body mass index (BMI), increased oxygen consumption and hyper-avoidance behavior. Exposure to benzo[a]pyrene during development resulted in transgenerational inheritance of neurobehavioral and physiological deficiencies. Indirect evidence suggested the potential for an AHR2-dependent epigenetic route.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish

Knecht

Truong

Marvel

et al. 2017

Toxicology and Applied Pharmacology

116

View full text Add to dashboard Cite

show abstract

“…An AutoResp swim tunnel, a Fibox fiber optic oxygen probe, and an oxy4 sensor (Loligo Systems, Denmark) were used to measure the oxygen consumption rate in groups of 8 adult zebrafish as previously described with small modifications [28]. Briefly eight animals per group were weighed prior to the experiment and then placed in the large swim tunnel in a 2.5 L tank with an oxygen sensor connected to the AutoResp software.…”

Section: Methodsmentioning

confidence: 99%

“…Briefly eight animals per group were weighed prior to the experiment and then placed in the large swim tunnel in a 2.5 L tank with an oxygen sensor connected to the AutoResp software. Oxygen consumption rate measurements (O 2 mg/kg/hr) were taken every 10 min, consisting of a 240s flush period, in which water was renewed in the swim tunnel with a flush pump, then the pump was turned off to create a closed system during a 60s wait period, and a 300s measure period, as described in [28]. The zebrafish were given a 30 min acclimation period followed by a 30 min free swim at a water flow of 5 cm/sec (108 rpm) before swimming against a water current of 25 and 45 cm/sec (504 and 901 rpm respectively).…”

Section: Methodsmentioning

confidence: 99%

Adverse effects of parental zinc deficiency on metal homeostasis and embryonic development in a zebrafish model

Beaver

Nkrumah‐Elie

Truong

et al. 2017

The Journal of Nutritional Biochemistry

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The high prevalence of zinc deficiency is a global public health concern, and suboptimal maternal zinc consumption has been associated with adverse effects ranging from impaired glucose tolerance to low birthweights. The mechanisms that contribute to altered development and poor health in zinc deficient offspring are not completely understood. To address this gap, we utilized the Danio rerio model and investigated the impact of dietary zinc deficiency on adults and their developing progeny. Zinc deficient adult fish were significantly smaller in size, and had decreases in learning and fitness. We hypothesized that parental zinc deficiency would have an impact on their offspring’s mineral homeostasis and embryonic development. Results from mineral analysis showed that parental zinc deficiency caused their progeny to be zinc deficient. Furthermore, parental dietary zinc deficiency had adverse consequences for their offspring including a significant increase in mortality and decreased physical activity. Zinc deficient embryos had altered expression of genes that regulate metal homeostasis including several zinc transporters (ZnT8, ZnT9) and the metal-regulatory transcription factor 1 (MTF-1). Zinc deficiency was also associated with decreased expression of genes related to diabetes and pancreatic development in the embryo (Insa, Pax4, Pdx1). Decreased expression of DNA methyltransferases (Dnmt4, Dnmt6) was also found in zinc deficient offspring, which suggests that zinc deficiency in parents may cause altered epigenetic profiles for their progeny. These data should inform future studies regarding zinc deficiency and pregnancy and suggest that supplementation of zinc deficient mothers prior to pregnancy may be beneficial.

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“…Several studies have reported U crit of wild‐type adult D . rerio (Plaut, ; McClelland et al , ; Widmer et al , ; Palstra et al , ; Sfakianakis et al , ; Seebacher & Walter, ; Leris et al , ; Masse et al , ; Gilbert et al , ). These published estimates of U crit cover a range of values, from c .…”

Section: Discussionmentioning

confidence: 99%

Sexually dimorphic morphology and swimming performance relationships in wild‐type zebrafish Danio rerio

Conradsen

McGuigan

2015

Journal of Fish Biology

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This study compared prolonged swimming performance (Ucrit ) between male and female Danio rerio, and characterized how body shape was associated with this performance measure in each sex. When swimming in small (n = 6) mixed-sex groups at 28 °C, males swam, on average, over 10 cm s(-1) faster than females despite being significantly smaller. Body shape was sexually dimorphic, with males and females exhibiting small, but statistically significant differences in most aspects of body shape. Body shape explained 18 and 43% of the variation in Ucrit among males and females. In general, effects of body shape on swimming performance appeared to be sex limited, whereby different aspects of body shape affected performance in each sex, although the contribution of the distance between pelvic and anal fins to swimming performance was weakly sexually antagonistic.

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Reduced swim performance and aerobic capacity in adult zebrafish exposed to waterborne selenite

Cited by 24 publications

References 19 publications

Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish

Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish

Adverse effects of parental zinc deficiency on metal homeostasis and embryonic development in a zebrafish model

Sexually dimorphic morphology and swimming performance relationships in wild‐type zebrafish Danio rerio

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