Reduced sulphation factor in undernourished children.

Grant, Derek; Hambley, Judy; Becker, Dorothy J.; Pimstone, B. L.

doi:10.1136/adc.48.8.596

Cited by 200 publications

(69 citation statements)

References 17 publications

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“…Serum IGF-I levels were significantly lower in CF patients than in controls. At variance with previous studies this did not seem to be dependent on malnutrition or anorexia (9,14,28,29) as the BMI values of these patients were normal and similar to those of controls, and total serum protein concentration was normal. Other authors have hypothesized that low serum IGF-I concentrations could be dependent on insulin hyposecretion in CF.…”

Section: Discussioncontrasting

confidence: 45%

“…However, this group of patients had basal insulin levels similar or greater than controls. Furthermore, the low IGF-I serum levels cannot be ascribed to impaired liver function (14,16) as liver function tests were normal in all the subjects. In the case of impaired liver function insulin clearance would be reduced; however, C-peptide, which is metabolized by the kidneys, showed a similar pattern to insulin, suggesting that this is very unlikely.…”

Section: Discussionmentioning

confidence: 99%

“…However, at least 20-30% of CF patients present with childhood growth delay and/or weight deficit (9 -12). In CF, serum IGF-I levels have been described to be normal (13) or below the normal range for age and it has been suggested that this could be secondary to liver dysfunction, impaired glucose tolerance, pubertal delay or chronic inflammation (9,14).…”

Section: Introductionmentioning

confidence: 99%

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Inflammation is a modulator of the insulin-like growth factor (IGF)/IGF-binding protein system inducing reduced bioactivity of IGFs in cystic fibrosis

et al. 2006

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Objective: In inflammatory bowel diseases, increased serum interleukin (IL)-6 levels are associated with high serum insulin-like growth factor-binding protein 2 (IGFBP-2) levels, and cytokines modify the insulin-like growth factor (IGF)/IGFBP system in models in vitro. In cystic fibrosis (CF) the IGF/IGFBP system has not been extensively studied, and relationships with proinflammatory cytokines have not been explored. The aim of this study was to investigate the IGF/IGFBP system and verify changes dependent on IL-1b, IL-6, tumour necrosis factor a (TNFa), and insulin. Methods: Eighteen subjects with CF (mean age 26.6^1.1 years) and 18 controls, comparable for age, sex, and body mass index, were enrolled. Serum IGF-I, IGF-II, IGFBP-2, IGFBP-3, IL-1b, IL-6, TNFa, insulin and C-peptide were measured. Different molecular forms of IGFBP-2 and IGFBP-3 were investigated by Western immunoblotting. The patients were analysed as a whole and as two subgroups depending on established clinical criteria (Swachman -Kulczycki score). Results: Patients had higher serum concentrations of IL-1b, IL-6, TNFa and IGFBP-2 than controls. Serum concentrations of IGF-I and IGF-II were significantly lower and insulin and C-peptide levels significantly increased in CF compared with healthy controls whereas IGFBP-3 serum concentrations were similar, with comparable IGF-I/IGFBP-3 and decreased IGF-I/IGFBP-2 and IGF-II/IGFBP-2 molar ratios. From correlation analysis we detected a significant positive correlation between IGFBP-2 and IL-6 and a negative correlation between IGFBP-2 and IGFBP-3. Conclusions: Our findings suggest that inflammation is an important modulator of the IGF/IGFBP system with an overall reduction in IGF bioactivity in CF.European Journal of Endocrinology 154 47-52

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Section: Discussioncontrasting

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inflammation is a modulator of the insulin-like growth factor (IGF)/IGF-binding protein system inducing reduced bioactivity of IGFs in cystic fibrosis

et al. 2006

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“…Grant et al (1973) observed that serum somatomedins bioactivity was low in children with protein-calorie malnutrition, despite high GH .. levels. Merimee ~ ~ (1982) later showed that after three days of fasting, normal subjects showed no chanqe in serum IGF-I in response to GH injections.…”

Section: Rutritiohal Regulation Op Igp-imentioning

confidence: 99%

The effect of growth hormone treatment on growth in zinc deficient rats

1993

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“…Growth failure in patients with PEM has been attributed to a deficiency in the generation of the somatomedins (3,4). Thus, measurements of somatomedin concentration may be an accurate index of nitrogen balance (flux) in such patients (5).…”

mentioning

confidence: 99%

Serum Insulin-Like Growth Factors I and II Concentrations and Growth Hormone and Insulin Responses to Arginine Infusion in Children with Protein-Energy Malnutrition before and after Nutritional Rehabilitation

et al. 1986

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ABSTRACT. Serum insulin, growth hormone (GH), insulin-like growth factors (IGFs) I and 11, cortisol, and albumin concentrations were measured in 15 children with kwashiorkor, 15 with marasmic-kwashiorkor, and 21 with marasmus, before and in the survivors, after nutritional rehabilitation, as well as in 10 underweight and eight normal Egyptian children. We also evaluated arginineinduced insulin and GH secretion. IGF-I concentrations were reduced in the three severely malnourished groups (0.07 2 0.03, 0.05 + 0.03, and 0.09 f 0.09 U/ml, respectively) but returned to normal after refeeding. IGF-I1 concentrations were low in the kwashiorkor (175 f 79 ng/ml), marasmic-kwashiorkor (1 11 2 57 ng/ml), and marasmic children (128 2 70.9 ng/ml) and returned to normal after nutritional rehabilitation. Basal GH levels were high in the three severely malnourished groups (21.9, 28.8, and 16.6 ng/ml, respectively) and returned to normal after refeeding (8.1, 6.5, and 6.0 ng/ml, respectively). GH responses to arginine were depressed in the three malnourished groups and improved significantly in marasmic-kwashiorkor and marasmic children after nutritional rehabilitation. Insulin responses to arginine were impaired in kwashiorkor, and marasmic-kwashiorkor children and improved significantly after refeeding. IGF-I levels correlated significantly with percent of expected weight ( r = 0.52, p < 0.001), percent of expected height ( r = 0.42, p < 0.001), and weight/ (height)' index ( r = 0 . 3 4 ,~ < 0.01). IGF-I levels correlated positively with insulin levels ( r = 0.421, p < 0.001) and negatively with cortisol concentrations ( r = -0.400, p <

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Reduced sulphation factor in undernourished children.

Cited by 200 publications

References 17 publications

Inflammation is a modulator of the insulin-like growth factor (IGF)/IGF-binding protein system inducing reduced bioactivity of IGFs in cystic fibrosis

Inflammation is a modulator of the insulin-like growth factor (IGF)/IGF-binding protein system inducing reduced bioactivity of IGFs in cystic fibrosis

The effect of growth hormone treatment on growth in zinc deficient rats

Serum Insulin-Like Growth Factors I and II Concentrations and Growth Hormone and Insulin Responses to Arginine Infusion in Children with Protein-Energy Malnutrition before and after Nutritional Rehabilitation

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