Reduced Skeletal Muscle Oxygen Uptake and Reduced β-Cell Function

Thamer, Claus; Stümvoll, Michael; Nieß, Andreas M.; Tschritter, Otto; Haap, Michael; Becker, R.; Shirkavand, Fatemeh; Bachmann, Oliver; Rett, K.; Volk, A.; Häring, Hans Ulrich; Fritsche, Andreas

doi:10.2337/diacare.26.7.2126

Cited by 58 publications

(38 citation statements)

References 31 publications

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“…If anything, FH+ individuals had adopted healthier food habits than FH− participants. In support of our findings, Thamer et al also showed in a study of young healthy individuals that a family history of diabetes was associated with lower oxygen uptake [11].…”

Section: Discussionsupporting

confidence: 92%

A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)–Botnia study

Isomaa

Forsén²,

Lahti

et al. 2010

Diabetologia

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Aims/hypothesis We studied the impact of a family history of type 2 diabetes on physical fitness, lifestyle factors and diabetes-related metabolic factors. Methods The Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia study is a population-based study in Western Finland, which includes a random sample of 5,208 individuals aged 18 to 75 years identified through the national Finnish Population Registry. Physical activity, dietary habits and family history of type 2 diabetes were assessed by questionnaires and physical fitness by a validated 2 km walking test. Insulin secretion and action were assessed based upon OGTT measurements of insulin and glucose. Results A family history of type 2 diabetes was associated with a 2.4-fold risk of diabetes and lower physical fitness (maximal aerobic capacity 29.2±7.2 vs 32.1±7.0, p=0.01) despite having similar reported physical activity to that of individuals with no family history. The same individuals also had reduced insulin secretion adjusted for insulin resistance, i.e. disposition index (p<0.001) despite having higher BMI (27.4±4.6 vs 26.0±4.3 kg/m 2 , p<0.001).Electronic supplementary material The online version of this article

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Section: Discussionsupporting

confidence: 92%

A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)–Botnia study

Isomaa

Forsén²,

Lahti

et al. 2010

Diabetologia

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“…We studied 1,469 nondiabetic white subjects (>98% of German ancestry) who participated in the ongoing Tübingen Family Study for type 2 diabetes, which currently includes ~2,000 individuals (16). All participants underwent physical examination, medical history assessment, routine blood tests, and an oral glucose tolerance test (OGTT).…”

Section: Methods and Procedures Subjectsmentioning

confidence: 99%

Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole‐body MRI/MRS study

Haupt

Thamer

Heni

et al. 2010

Obesity

Self Cite

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A recent meta‐analysis of genome‐wide association studies has identified six new risk‐loci for common obesity. We studied whether these risk loci influence the distribution of body fat depots. We genotyped 1,469 nondiabetic subjects for the single‐nucleotide polymorphisms (SNPs) TMEM18 rs6548238, KCTD15 rs11084753, GNPDA2 rs10938397, SH2B1 rs7498665, MTCH2 rs10838738, and NEGR1 rs2815752. We assessed BMI, waist circumference, total body fat, and lean body mass (bioimpedance). All subjects underwent an oral glucose tolerance test (OGTT) for estimation of insulin sensitivity. In 332 subjects, we measured total adipose tissue (TAT), visceral adipose tissue (VAT), nonvisceral adipose tissue (NVAT), liver fat content, and intramyocellular lipids (IMCLs) using whole‐body magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). In the dominant inheritance model, the risk alleles of TMEM18 rs6548238 and MTCH2 rs10838738 were nominally associated with higher BMI (P = 0.04, both). The risk allele of TMEM18 rs6548238 was additionally associated with higher waist circumference and total body fat (P ≤ 0.03), the risk allele of NEGR1 rs2815752 with higher waist circumference (P = 0.05) and unexpectedly with lower BMI (P = 0.01). In the MR cohort, we found an association of the risk allele of SH2B1 rs7498665 with higher VAT (P = 0.009) and of GNPDA2 rs10938397 with increased IMCLs (P = 0.03). After Bonferroni correction for multiple comparisons (corrected α‐level: P = 0.0085), none of the SNPs was significantly associated with measures of adiposity or body fat distribution (all P > 0.009, dominant inheritance model). Therefore, our results suggest that these new obesity SNPs, despite their influence on BMI, are neither associated with a metabolically unfavorable nor with a favorable body composition.

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“…Insulin resistance was determined by two methods; homeostasis model assessment of insulin resistance (HOMA-IR) calculated as the product of the fasting plasma insulin (µU/ml) and the fasting plasma glucose level (mg/dl) divided by 405 and the composite whole-body-insulin-sensitivity index (WBISI) calculated using mean values of insulin (µU/ml) and glucose (mg/dl) obtained from the OGTT and corresponding fasting values [21]. The appropriateness of beta cell function for the individual insulin sensitivity was evaluated by the disposition index, calculated as the product of IGI and WBISI [22][23][24].…”

Section: Calculationsmentioning

confidence: 99%

Preferable Effect of Pravastatin Compared to Atorvastatin on Beta Cell Function in Japanese Early-state Type 2 Diabetes with Hypercholesterolemia

et al. 2007

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Abstract. While a large numbers of clinical trials using various kinds of statins has been reported, a possible preventive effect on new onset of type 2 diabetes mellitus was shown only by the subanalysis of The West of Scotland Coronary Prevention Study (WOSCOPS) using pravastatin. The aim of this study was to investigate whether pravastatin has a preferable effect on glucose tolerance among statins. An open-label prospective cross-over trial was performed to compare the effect of pravastatin (10 mg/day) or atorvastatin (10 mg/day) in Japanese early-state type 2 diabetes mellitus with hypercholesterolemia. The analyzed study subjects were treated with pravastatin (10 mg/day, n = 12) or atorvastatin (10 mg/day, n = 12) for 12 weeks. After a 4-week-washout period, the drugs were switched and treatment was continued for another 12 weeks. Oral glucose tolerance test (OGTT) was performed to evaluate several parameters including the appropriateness of beta cell function for the individual insulin sensitivity (disposition index: product of a validated secretion parameter and sensitivity) at the end of each therapy. HbA 1c and 2 h-glucose levels during OGTT in the pravastatin treatment were significantly lower than atorvastatin treatment. Disposition index after pravastatin treatment was significantly higher than after atorvastatin treatment. In conclusion, our study suggests that pravastatin has a favorable effect on pancreatic beta cell function compared with atorvastatin.

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Reduced Skeletal Muscle Oxygen Uptake and Reduced β-Cell Function

Cited by 58 publications

References 31 publications

A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)–Botnia study

A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)–Botnia study

Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole‐body MRI/MRS study

Preferable Effect of Pravastatin Compared to Atorvastatin on Beta Cell Function in Japanese Early-state Type 2 Diabetes with Hypercholesterolemia

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