Reduced six-minute walking distance, high fat-free-mass index and hypercapnia are associated with endothelial dysfunction in COPD

Minet, Clémence; Vivodtzev, Isabelle; Tamisier, Renaud; Arbib, François; Wuyam, Bernard; Timsit, Jean‐François; Monneret, Denis; Borel, Jean‐Christian; Baguet, Jean-Philippe; Lévy, Patrick; Pépin, Jean‐Louis

doi:10.1016/j.resp.2012.06.017

Cited by 34 publications

(41 citation statements)

References 30 publications

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“…Endothelial dysfunction is associated with severity of COPD and is related to FEV1 [64–66]. Dysfunction is also related to clinical outcomes: patients with increased endothelial dysfunction have reduced 6 minute walk test (6MWT) results and a worse overall prognosis [67, 68]. Endothelial dysfunction is also increased in patients with exacerbations of COPD [69, 70].…”

Section: Introductionmentioning

confidence: 99%

The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

Green

Turner

2017

Respir Res

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COPD and asthma are important chronic inflammatory disorders with a high associated morbidity. Much research has concentrated on the role of inflammatory cells, such as the neutrophil, in these diseases, but relatively little focus has been given to the endothelial tissue, through which inflammatory cells must transmigrate to reach the lung parenchyma and cause damage. There is evidence that there is an abnormal amount of endothelial tissue in COPD and asthma and that this tissue and its’ progenitor cells behave in a dysfunctional manner. This article reviews the evidence of the involvement of pulmonary endothelium in COPD and asthma and potential treatment options for this.

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Section: Introductionmentioning

confidence: 99%

The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

Green

Turner

2017

Respir Res

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“…Up to our knowledge, only two prior cross‐sectional studies assessed endothelial function (RHI), and only one AIx with PAT in patients with COPD (Minet et al, ; Vaes, Spruit, Theunis, Wouters, & De Boever, ). Minet et al () found a mean RHI of 0.43 ranging from −0.14 to 1.3. Although that sample had lower RHI values than the current study, the airflow limitation was less severe.…”

Section: Discussionmentioning

confidence: 99%

The effects of pulmonary rehabilitation on endothelial function and arterial stiffness in patients with chronic obstructive pulmonary disease

Araújo

Reinaldo

Foscarini

et al. 2019

Physiotherapy Res Intl

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Objectives Cardiovascular disease is a major cause of mortality in chronic obstructive pulmonary disease (COPD) and endothelial dysfunction may enhance the mortality risk. Exercise training has shown to be beneficial for improvement of endothelial function in patients with cardiovascular disease, but this remains unclear in COPD. Thus, this study aimed to assess the effect of exercise‐based pulmonary rehabilitation (PR) on endothelium function, arterial stiffness and plasma nitrite levels in patients with COPD. Methods Patients with COPD engaged a 48‐session PR program. Reactive hyperaemia index (RHI), augmentation index (AIx), and heart rate (HR) assed by peripheral arterial tonometry (PAT), plasma nitrite levels, systemic blood pressure, functional capacity (six‐minute walk test) and the BODE index were assessed at baseline and after 24 and 48 sessions of PR. Plasma nitrite levels were also assessed before and after the first session of PR. Results Twenty‐one subjects were included and completed 24 PR sessions, and 16 subjects completed 48 sessions. It was observed that a poorer AIx adjusted for HR in frequent COPD exacerbators (4.67 ± 16.5 vs. 20.9 ± 12.9; p = .02). PR improved functional capacity (380 ± 107 m vs. 442 ± 115 m; p < .001) and the BODE index (6 [2.8] vs. 4 [3]; p = .001), but did not change HR, systemic arterial pressure, RHI, AIx, and plasma nitrite levels during the follow‐up. Plasma nitrite levels reduced after the first session of PR (0.074 [0.079] μM vs. 0.061 [0.04] μM; p = .027). The acute change in plasma nitrite levels correlated with RHI in patients with preserved endothelial function (r = 0.71; p = .01). Conclusions Although exercise‐based PR improved functional capacity and the BODE index, it did not change endothelial function and arterial stiffness in patients with COPD.

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“…Arterial stiffness was assessed by carotid-femoral PWV as measured with a Complior device (Artech Medical; Pantin, France) 16. Endothelial function was assessed by reactive hyperaemia using finger plethysmography with an Endo-PAT device (Itamar Medical Ltd, Caesarea, Israel) 17. Body composition was estimated using bioelectrical impedance (Bodystat 1500, Isle of Man, UK, in the French centre and InBody 570, Biospace, Seoul, Korea, in the Canadian centre).…”

Section: Methodsmentioning

confidence: 99%

Ventilatory support or respiratory muscle training as adjuncts to exercise in obese CPAP-treated patients with obstructive sleep apnoea: a randomised controlled trial

Vivodtzev

Tamisier

Croteau

et al. 2018

Thorax

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Reduced six-minute walking distance, high fat-free-mass index and hypercapnia are associated with endothelial dysfunction in COPD

Cited by 34 publications

References 30 publications

The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

The effects of pulmonary rehabilitation on endothelial function and arterial stiffness in patients with chronic obstructive pulmonary disease

Ventilatory support or respiratory muscle training as adjuncts to exercise in obese CPAP-treated patients with obstructive sleep apnoea: a randomised controlled trial

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