Reduced Serum Zinc Ion Concentration Is Associated with Coronary Heart Disease

Meng, Heyu; Wang, Yueying; Zhou, Fengfeng; Ruan, Jianjun; Duan, Meiyu; Wang, Xue; Yu, Qiong; Yang, Ping; Chen, Weiwei; Meng, F.

doi:10.1007/s12011-020-02551-8

Cited by 19 publications

(17 citation statements)

References 52 publications

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“…Research studies have shown that trace elements in the body are closely related to many disease including coronary heart diseases [26,27]. In a previous study from our lab, we found that zinc ions are related to menopause, and supplementation of zinc ions has a positive effect on the treatment of coronary heart disease [26].…”

Section: Introductionmentioning

confidence: 81%

Decreased Iron Ion Concentrations in the Peripheral Blood Correlate with Coronary Atherosclerosis

et al. 2022

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(1) Background: Obesity and diabetes continue to reach epidemic levels in the population with major health impacts that include a significantly increased risk of coronary atherosclerosis. The imbalance of trace elements in the body caused by nutritional factors can lead to the progression of coronary atherosclerosis. (2) Methods: We measured the concentrations of sodium (Na), potassium (K), magnesium (Mg), calcium (Ca), Zinc (Zn), and iron (Fe) in peripheral blood samples from 4243 patients and performed baseline analysis and propensity matching of the patient datasets. The patients were grouped into acute myocardial infarction (AMI, 702 patients) and stable coronary heart disease (SCAD1, 253 patients) groups. Both of these groups were included in the AS that had a total of 1955 patients. The control group consisted of 2288 patients. The plasma concentrations of calcium, magnesium, and iron were measured using a colorimetric method. For comparison, 15 external quality assessment (EQA) samples were selected from the Clinical Laboratory Center of the Ministry of Health of China. SPSS software was used for statistical analysis. The average values and deviations of all of the indicators in each group were calculated, and a p-value threshold of <0.05 was used to indicate statistical significance. (3) Results: The iron ion concentrations of the acute myocardial infarction (AMI) group were significantly lower than the control group (p < 0.05, AUC = 0.724, AUC = 0.702), irrespective of tendency matching. Compared to the data from the stable coronary artery disease (SCAD) group, the concentration of iron ions in the acute myocardial infarction group was significantly lower (p < 0.05, AUC = 0.710, AUC = 0.682). Furthermore, the iron ion concentrations in the (AMI + SCAD) group were significantly lower (p < 0.05) than in the control group. (4) Conclusions: The data presented in this study strongly indicate that the concentration of iron ions in the peripheral blood is related to coronary atherosclerosis. Decreases in the levels of iron ions in the peripheral blood can be used as a predictive biomarker of coronary atherosclerosis.

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Section: Introductionmentioning

confidence: 81%

Decreased Iron Ion Concentrations in the Peripheral Blood Correlate with Coronary Atherosclerosis

et al. 2022

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“…The basis for the relationship between the zinc ion concentration and coronary heart disease in the Meng et al study [1] should be confirmed. First, the coronary heart disease group differed from the control group with respect to age, smoking history, co-existing diabetes or hypertension, and blood glucose, total cholesterol, high-density lipoprotein, low-density lipoprotein, and zinc levels.…”

Section: Dear Editormentioning

confidence: 88%

“…We were pleased to read the research article by Meng et al [1], who found that a decreased zinc ion concentration in the peripheral blood could be used as an independent risk factor for the prediction of coronary heart disease, especially in older patients, non-smokers, and women (especially postmenopausal women). Although this finding may have an important role in the prevention and treatment of coronary heart disease, some questions warrant further discussion.…”

Section: Dear Editormentioning

confidence: 99%

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Long-Term Use of Anti-Coronary Heart Disease Medications May Impact the Serum Zinc Concentration

Shi

2022

Biol Trace Elem Res

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“…A large proportion of the patients studied showed serological zinc deficiency which is consistent with the suggestion that even in the western world many people are affected by zinc deficiency with predominance of older people and patients with chronic diseases among those affected. So far, a clear relationship between atherosclerosis and zinc deficiency has not been proven with certainty 22 , 30 , but other studies suggested a correlation between low zinc levels and atherosclerotic diseases such as an association between zinc deficiency and coronary heart disease 31 . Previously published studies underlined that zinc deficiency appears to promote the production of proinflammatory cytokines such as IL-1β, tumor necrosis factor alpha (TNFα), and IL-6 by myeloid cells and activated monocytes/macrophages 32 , 33 .…”

Section: Discussionmentioning

confidence: 99%

Retrospective observational study evaluating zinc plasma level in patients undergoing thoracoabdominal aortic aneurysm repair and its correlation with outcome

Rolles

Weßels

Doukas

et al. 2021

Sci Rep

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Thoracoabdominal aortic aneurysm (TAAA) repair is related to a relevant morbidity and in-hospital mortality rate. In this retrospective observational single-center study including serum zinc levels of 33 patients we investigated the relationship between zinc and patients’ outcome following TAAA repair. Six patients died during the hospital stay (18%). These patients showed significantly decreased zinc levels before the intervention (zinc levels before intervention: 60.09 µg/dl [survivors] vs. 45.92 µg/dl [non-survivors]). The post-interventional intensive care SOFA-score (Sepsis-related organ failure assessment) (at day 2) as well as the SAPS (Simplified Acute Physiology Score) (at day 2) showed higher score points in case of low pre-interventional zinc levels. No significant correlation between patient comorbidities and zinc level before intervention, except for peripheral arterial disease (PAD), which was significantly correlated to reduced baseline zinc levels, was observed. Septic shock, pneumonia and urinary tract infections were not associated to reduced zinc levels preoperatively as well as during therapy. Patients with adverse outcome after TAAA repair showed reduced pre-interventional zinc levels. We speculate that decreased zinc levels before intervention may be related to a poorer outcome because of poorer physical status as well as negatively altered perioperative inflammatory response.

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Reduced Serum Zinc Ion Concentration Is Associated with Coronary Heart Disease

Cited by 19 publications

References 52 publications

Decreased Iron Ion Concentrations in the Peripheral Blood Correlate with Coronary Atherosclerosis

Decreased Iron Ion Concentrations in the Peripheral Blood Correlate with Coronary Atherosclerosis

Long-Term Use of Anti-Coronary Heart Disease Medications May Impact the Serum Zinc Concentration

Retrospective observational study evaluating zinc plasma level in patients undergoing thoracoabdominal aortic aneurysm repair and its correlation with outcome

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