Reduced Serum Concentrations of Carboxylated and Undercarboxylated Osteocalcin Are Associated With Risk of Developing Type 2 Diabetes Mellitus in a High Cardiovascular Risk Population: A Nested Case-Control Study

Díaz-López, Andrés; Bulló, Mònica; Juanola‐Falgarona, Martí; Martínez‐González, Miguel A.; Estruch, Ramón; Covas, Marı́a-Isabel; Arós, Fernando; Salas‐Salvadó, Jordi

doi:10.1210/jc.2013-2472

Cited by 84 publications

(72 citation statements)

References 31 publications

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“…The above mentioned studies could explain our data on the effect of iPTH on glucose metabolism partially mediated by osteocalcin, and to a less extent by uOC without influence on insulin secretion. This result is in contrast with animal data (1, 2), whereas it confirms a human study by Díaz-López et al (25). In animal models uOC has the deeper effect on glucose metabolism as respect to OC (1,2), whereas in humans OC, but not uOC, was inversely associated with insulin resistance and with FPG (25).…”

Section: Discussionsupporting

confidence: 69%

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Effect of intermittent PTH treatment on plasma glucose in osteoporosis: A randomized trial

Sassi

Buondonno

Spertino

et al. 2015

Bone

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Section: Discussionsupporting

confidence: 69%

“…This result is in contrast with animal data (1, 2), whereas it confirms a human study by Díaz-López et al (25). In animal models uOC has the deeper effect on glucose metabolism as respect to OC (1,2), whereas in humans OC, but not uOC, was inversely associated with insulin resistance and with FPG (25).…”

Section: Discussionsupporting

confidence: 69%

Effect of intermittent PTH treatment on plasma glucose in osteoporosis: A randomized trial

Sassi

Buondonno

Spertino

et al. 2015

Bone

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“…В одном из исследований обнаружено снижение остео-кальцина в сыворотке пациентов с СД2 в сравнении с контролем [18]. В мета-анализе состояния сыворо-точных маркеров при СД было обнаружено снижение уровней остеокальцина и C-концевого телопептида коллагена 1 типа (CTX) и повышение содержания кост-ной щелочной фосфатазы у пациентов по сравнению с контролем [13].…”

Section: риск переломов при сд2 -статистические данныеunclassified

Fragility fractures and bone remodeling in type 2 diabetes mellitus

et al. 2017

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Fracture risk is significantly increased in both type 1 and type 2 diabetes and individuals with diabetes experience worse fracture outcomes compared to normoglycemic individuals. Patients with T1DM have decreased bone mineral density (BMD), whereas patients with T2DM demonstrate increased BMD compared to healthy control. The latest studies show increased incidence of low-traumatic fractures in patients with T2DM instead of high bone mineral density (BMD). The risk of osteoporotic fractures in patients with T2DM can be explained by disease complications and increased risk of falls and consequent trauma. However, the most important cause of bone fragility in T2DM is the deterioration in bone microarchitecture, the mechanism of which is not completely understood. High BMD in patients with T2DM does not allow us to use dual-energy X-ray-absorptiometry as a gold standard test for diagnosticsof osteoporosis. Consequently,new risk factors and diagnostic algorithm as well as treatment strategy should be developed for patients with T2DM. In addition to this, some researchers considered that the group of T2DM is geterogenous and physicians might face patients with osteoporosis and mild diabetes that add very little to bone fragility; patients with osteoporosis and moderate or severe diabetes which also affects bone tissue diabetoosteoporosis; and patients without osteoporosis but severe diabetes which cause bone tissue deterioration with the development of diabetic bone disease. New diagnostic tools and algorithm and new experimental research are needed for better understanding bone deterioration in patients with T2DM. This review summarizes our current knowledge on fracture rate, risk factors for fractures and causes of bone deterioration in subjects with T2DM.

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“…However, moving from the preclinical to the clinical setting has been more difficult in establishing the relationship between this system and metabolic homeostasis. (23,53,54) Bioenergetics of the skeleton More recently, attention has focused on other mechanisms related to stem cell fate; in particular, the metabolic program of MSC progenitors. There is now emerging evidence that adipocytes and osteoblasts have distinct energy utilization pathways as they move down their respective lineages during differentiation.…”

Section: Skeletal Control Of Metabolic Balancementioning

confidence: 99%

Energy Excess, Glucose Utilization, and Skeletal Remodeling: New Insights

Lecka‐Czernik

Rosen

2015

Journal of Bone and Mineral Research

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Skeletal complications have recently been recognized as another of the several comorbidities associated with diabetes. Clinical studies suggest that disordered glucose and lipid metabolism have a profound effect on bone. Diabetes-related changes in skeletal homeostasis result in a significant increased risk of fractures, although the pathophysiology may differ from postmenopausal osteoporosis. Efforts to understand the underlying mechanisms of diabetic bone disease have focused on the direct interaction of adipose tissue with skeletal remodeling and the potential influence of glucose utilization and energy uptake on these processes. One aspect that has emerged recently is the major role of the central nervous system in whole-body metabolism, bone turnover, adipose tissue remodeling, and beta cell secretion of insulin. Importantly, the skeleton contributes to the metabolic balance inherent in physiologic states. New animal models have provided the insights necessary to begin to dissect the effects of obesity and insulin resistance on the acquisition and maintenance of bone mass. In this Perspective, we focus on potential mechanisms that underlie the complex interactions between adipose tissue and skeletal turnover by focusing on the clinical evidence and on preclinical studies indicating that glucose intolerance may have a significant impact on the skeleton. In addition, we raise fundamental questions that need to be addressed in future studies to resolve the conundrum associated with glucose intolerance, obesity, and osteoporosis. © 2015 American Society for Bone and Mineral Research. KEY WORDS: BONE-FAT INTERACTIONS; SYSTEMS BIOLOGY; BONE INTERACTORS; CELL/TISSUE SIGNALING; TRANSCRIPTION FACTORS; DISEASES AND DISORDERS OF/RELATED TO BONE Clinical Insight Into the Effect of Disordered Glucose and Lipids Homeostasis on BoneD iabetes mellitus (DM) can be considered a disease of intracellular glucose starvation in muscle and fat, due to either lack of insulin (Type 1 [T1D]) or impaired insulin action (Type 2 [T2D]). Both types of DM are associated with an increase in fractures; however, the skeletal phenotype is very different. T1D patients have reduced bone mineral density (BMD), due to insulin and amylin deficiency, whereas T2D patients have either normal or high BMD. T2D is a disease of disordered energy storage as well as glucose intolerance and altered bone strength. Its prevalence is high and not abating. In the United States, 29.1 million people-9.3% of the population-have diabetes; among them, nearly 60% are characterized as obese (http://www.cdc.gov). Insulin resistance is a characteristic feature of T2D in liver, muscle, and fat, leading to glucose intolerance, elevated cardiometabolic risk factors (eg, low-density lipoprotein [LDL] cholesterol), and excess hepatic glucose output. Visceral adipocytes, in particular, are large and surrounded by fibrous and inflammatory elements.In clinical medicine a major paradox is the relationship of obesity to the skeleton. Obese individuals tend to have higher...

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Reduced Serum Concentrations of Carboxylated and Undercarboxylated Osteocalcin Are Associated With Risk of Developing Type 2 Diabetes Mellitus in a High Cardiovascular Risk Population: A Nested Case-Control Study

Abstract: In a population at high cardiovascular risk, low concentrations of serum cOC and ucOC were strongly associated with an increased risk of incident diabetes.

Cited by 84 publications

References 31 publications

Effect of intermittent PTH treatment on plasma glucose in osteoporosis: A randomized trial

Effect of intermittent PTH treatment on plasma glucose in osteoporosis: A randomized trial

Fragility fractures and bone remodeling in type 2 diabetes mellitus

Energy Excess, Glucose Utilization, and Skeletal Remodeling: New Insights

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