Reduced <scp>P300</scp> amplitude is consistently associated with trait anhedonia across repeated assessments

Santopetro, Nicholas J.; Mulligan, Elizabeth M.; Brush, Christopher J.; Hajcak, Greg

doi:10.1111/psyp.14127

Cited by 5 publications

(3 citation statements)

References 73 publications

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“…41 Response facilitation during the congruent stimuli condition is reflected as the cortical P3 response; these metrics have excellent internal consistency and acceptable-to-good test-retest reliability. 42…”

Section: Electroencephalography (Eeg) Data Collection and Analysesmentioning

confidence: 99%

“…We also used an established, standardized approach involving a channel-based, centralized, frontal region location analyses of cortical responses evoked during the Flanker task. 9,42 As such, future studies are needed to test whether there is a hemispheric lateralization effect for exercise-induced improvements in post-stroke cortical inhibitory mechanisms.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

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Aerobic exercise training selectively improves cortical inhibitory function after stroke

Palmer

Whitaker

Payne

et al. 2022

Preprint

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Background: Aerobic exercise elicits striking effects on neuroplasticity and cognitive executive function but is poorly understood after stroke. Objective: We tested the effect of 4 weeks of aerobic exercise training on inhibitory and facilitatory elements of cognitive executive function and electroencephalography (EEG) markers of cortical inhibition and facilitation. We investigated relationships between stimulus-evoked cortical responses, blood lactate levels during training, and aerobic fitness post-intervention. Methods: Twelve individuals with chronic (>6mo) stroke completed an intensive aerobic exercise intervention (40-mins, 3x/week). Electroencephalography and motor response times were assessed during congruent (response facilitation) and incongruent (response inhibition) stimuli of a Flanker task. Aerobic fitness capacity was assessed as VO2-peak during a treadmill test pre- and post-intervention. Blood lactate was assessed acutely (<1 min) after exercise each week. Cortical inhibition (N2) and facilitation (frontal P3) were quantified as peak amplitudes and latencies of stimulus evoked EEG activity over the frontal cortical region. Results: Following exercise training, the response inhibition speed increased while response facilitation remained unchanged. A relationship between earlier cortical N2 response and faster response inhibition emerged post-intervention. Individuals who produced higher lactate during exercise training achieved faster response inhibition and tended to show earlier cortical N2 responses post-intervention. There were no associations between VO2-peak and metrics of behavioral or neurophysiologic function. Conclusions: These findings provide novel evidence for selective benefits of aerobic exercise on inhibitory control during the initial 4-week period after initiation of exercise training, and implicate a potential therapeutic effect of lactate on post-stroke cortical inhibitory function.

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Section: Electroencephalography (Eeg) Data Collection and Analysesmentioning

confidence: 99%

Section: Strengths and Limitationsmentioning

confidence: 99%

Aerobic exercise training selectively improves cortical inhibitory function after stroke

Palmer

Whitaker

Payne

et al. 2022

Preprint

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“…It is worth noting that depressive patients generally exhibit diminished P300 amplitude responses for both true positive and false positive reactions (Röschke and Wagner, 2003). Furthermore, reduced P300 amplitudes in depression have been associated with trait anhedonia and higher depressive symptoms during follow-up, indicating a potential role of motivational and hedonic processes in P300 amplitudes among individuals with depression, as well as the electrophysiological marker for disease course (Santopetro et al, 2022(Santopetro et al, , 2021.…”

Section: Discussionmentioning

confidence: 99%

Associations between peripheral cytokines, perceived fatigue and event-related potentials during a sustained attention task in depressive episodes: a case-control study

Pedraz-Petrozzi,

Lamade,

Hübner

et al. 2023

Preprint

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This case-control study investigated the associations between peripheral inflammation, perceived fatigue, and event-related potentials (ERP) during a sustained attention test (SAT) in depression. Participants included 25 individuals with depressive episodes (DE) and 31 healthy controls (HC). A 15-minute SAT (subtest of the Test Battery for Attention, version 2.3.1) was administered with concurrent EEG recordings. Peripheral inflammation was assessed by measuring IL-6, IL-1β, and TNF-α cytokines. Linear mixed models and generalized linear models were utilized for data analysis. Our results showed that the DE group exhibited lower P300 amplitudes than HC (estimate = -0.98, CI95 [-1.60; -0.35], p = 0.004). Furthermore, P300 amplitudes were inversely associated with IL-6 (estimate = -1.73, CI95 [-3.27; -0.19], p = 0.03), regardless of group status. Surprisingly, higher perceived fatigue correlated with increased P300 amplitudes, irrespective of group status (estimate = 0.009, CI95 [0.0004; 0.02], p = 0.05). Finally, accuracy, measured as the total number of correct answers in the SAT, correlated negatively with TNF-α (OR = 0.44, CI95 [0.27; 0.70]). However, no significant effects were found for P300 latency or reaction time in the SAT when comparing DE and HC. The study highlights the potential role of peripheral inflammation on sustained attention in cognitive performance. Due to the low interaction effect, fatigue and P300 amplitude results must be interpreted cautiously. Although P300 amplitudes were lower in DE, no significant association was observed between DE and inflammation in ERP and cognitive performance. Further research is required to confirm these findings.

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Associations between physical activity, sedentary time, and neurocognitive function during adolescence: Evidence from accelerometry and the flanker P300

Brush,

Keith,

Santopetro

et al. 2024

Progress in Brain Research

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Reduced P300 amplitude is consistently associated with trait anhedonia across repeated assessments

Cited by 5 publications

References 73 publications

Aerobic exercise training selectively improves cortical inhibitory function after stroke

Aerobic exercise training selectively improves cortical inhibitory function after stroke

Associations between peripheral cytokines, perceived fatigue and event-related potentials during a sustained attention task in depressive episodes: a case-control study

Associations between physical activity, sedentary time, and neurocognitive function during adolescence: Evidence from accelerometry and the flanker P300

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