Reduced risk of metabolic syndrome due to regular intake of vegetables rich in antioxidants among African type 2 diabetics

Muaka, Moise Mvitu; Longo-Mbenza, Benjamin; D, Mona; Okwe, A. Nge

doi:10.1016/j.dsx.2010.07.003

Cited by 6 publications

(19 citation statements)

References 33 publications

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“…Other established risk factors of DR such as urbanization after migration, control of DM, micronutrients, vitamins, antioxidant markers, and oxidative stress biomarkers were consistent with the present univariate analyses as reported by other studies [3], [5]–[8], [9]–[12], [14]–[21], [31], [33]. Paradoxically, the present study showed onset of DR in youngest individuals with shorter DM duration as often reported in Africa [3], [4], [31], [33].…”

Section: Discussionsupporting

confidence: 92%

“…This survey was conducted in Kinshasa city, DRC, from July to September 2010, and is a part of the epidemiologic approach of new and established risk factors for T2DM and diabetic complications in the community [1]–[5], [14]. The study population was selected as a probability sample of 150 T2DM patients aged ≥20 years and drawn from the list of 1500 diabetics managed in each Kinshasa District.…”

Section: Methodsmentioning

confidence: 99%

“…All participants were asked to respond to a questionnaire concerning semi-quantitative food, frequency and intake (no vs. yes) of fumbwa vegetables and African pear safou (Figure 1), and number of portion size of other vegetables rich in antioxidants [5]. The 24-h dietary was assessed for darkly green fumbwa leaves and other vegetables intake, while vividly black, blue or pink African pear safou fruit concerned consumption during the 10 months (September 2009 to June 2010 : rainy season) before examination.…”

Section: Methodsmentioning

confidence: 99%

“…The preventive role of intake of vegetables rich in antioxidants, control of chronic hyperglycemia, early detection of microalbuminuria, control of dyslipidemia, control of arterial hypertension and vitamins supplements against metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM) and diabetic complications is now reported within sub-Saharan Africa and outside Africa [5]–[8]. African pear safou (Dacryodes edulis) [9] and fumbwa vegetables (GNETUM AFRICANUM), popular food plants in tropical Africa, are well known for their high concentrations in antioxidants [5].…”

Section: Introductionmentioning

confidence: 99%

“…African pear safou (Dacryodes edulis) [9] and fumbwa vegetables (GNETUM AFRICANUM), popular food plants in tropical Africa, are well known for their high concentrations in antioxidants [5].…”

Section: Introductionmentioning

confidence: 99%

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Intake of Gnetum Africanum and Dacryodes Edulis, Imbalance of Oxidant/Antioxidant Status and Prevalence of Diabetic Retinopathy in Central Africans

et al. 2012

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ObjectiveTo estimate the prevalence of DR and to correlate cardiometabolic, sociodemographic, and oxidant/antioxidant imbalance data to the prevalence of DR.DesignThis case-control study included type 2 DM (T2 DM) patients with DR (n = 66), T2 DM patients without DR (N = 84), and healthy controls (n = 45) without DR, in Kinshasa town. Diet, albuminemia, serum vitamins, and 8-isoprostane were examined.ResultsNo intake of safou (OR = 2.7 95% CI 1.2–5.8; P = 0.014), low serum albumin <4.5 g/dL (OR-2.9 95% CI 1.4–5.9; P = 0.003), no intake of fumbwa (OR = 2.8 95% CI 1.2–6.5; P = 0.014), high 8-isoprostane (OR = 14.3 95% CI 4.5–46; P<0.0001), DM duration ≥5 years (OR = 3.8 95% CI 1.6–9.1; P = 0.003), and low serum vitamin C (OR = 4.5 95% CI 1.3–15.5; P = 0.016) were identified as the significant independent determinants of DR.ConclusionThe important role of oxidant/antioxidant status imbalance and diet is demonstrated in DR.

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intake of Gnetum Africanum and Dacryodes Edulis, Imbalance of Oxidant/Antioxidant Status and Prevalence of Diabetic Retinopathy in Central Africans

et al. 2012

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The use of plants in the traditional management of diabetes in Nigeria: Pharmacological and toxicological considerations

Ezuruike

Prieto

2014

Journal of Ethnopharmacology

332

204

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Antidiabetic Activity of Terminalia sericea Constituents

Nkobole

Houghton

Hussein

et al. 2011

Natural Product Communications

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Diabetes mellitus is an endocrine disorder that affects more than 100 million people worldwide. South African plants namely Terminalia sericea, Euclea natalensis, Warbugia salutaris, Aloe ferox, Artemisia afra, Sclerocarya birrea, Spirostachys africana and Psidium guajava were investigated for their in vitro α-glucosidase and α-amylase properties, and antioxidant activities. Terminalia sericea stem bark extract showed the best results against α-glucosidase and α-amylase enzymes. Bioassay-guided fractionation of an acetone extract of T. sericea stem bark led to the isolation of four known compounds namely β-sitosterol (1), β-sitosterol-3-acetate (2), lupeol (3), and stigma-4-ene-3-one (4), in addition to two inseparable sets of mixtures of isomers [epicatechin-catechin (M1), and gallocatechin-epigallocatechin (M2). 1 and 3 showed the best inhibitory activity on α-glucosidase (IC 50 :54.5 and 66.5 µM). Bio-evaluation of the inhibitory activity of the purified compounds on α-amylase showed that 3 and 1 exhibited IC 50 values of 140.7 and 216.02 µM, respectively against α-amylase. Compounds 2, M1, 3 and M2 were found to be non-toxic to Vero cells. This study is the first to report -glucosidase and -amylase activity of M1, M2, 2 and 4 isolated from T. sericea, which validated the traditional use of the bark of T. sericea for diabetes in South Africa.

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Reduced risk of metabolic syndrome due to regular intake of vegetables rich in antioxidants among African type 2 diabetics

Cited by 6 publications

References 33 publications

Intake of Gnetum Africanum and Dacryodes Edulis, Imbalance of Oxidant/Antioxidant Status and Prevalence of Diabetic Retinopathy in Central Africans

Intake of Gnetum Africanum and Dacryodes Edulis, Imbalance of Oxidant/Antioxidant Status and Prevalence of Diabetic Retinopathy in Central Africans

The use of plants in the traditional management of diabetes in Nigeria: Pharmacological and toxicological considerations

Antidiabetic Activity of Terminalia sericea Constituents

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