Reduced right posterior hippocampal volume in women with recurrent familial pure depressive disorder

Nifosi, F.; Toffanin, Tommaso; Follador, Halima; Zonta, Filippo; Padovan, Giordano; Pigato, Giorgio; Carollo, C.; Ermani, Mario; Amistà, Pietro; Perini, Giulia

doi:10.1016/j.pscychresns.2010.05.012

Cited by 30 publications

(19 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Laterally reduced hippocampal volumes on the right side have been reported in depressed patients. 34 During memory encoding tasks, control subjects show more activity in the right hippocampus compared to depressive patients, 35 suggesting that right hippocampal functionality may be impaired in depression, which is common in HF. 36 The hippocampi exhibit lateralization in cerebral blood flow as well.…”

Section: Discussionmentioning

confidence: 99%

Visual Assessment of Brain Magnetic Resonance Imaging Detects Injury to Cognitive Regulatory Sites in Patients With Heart Failure

Pan

Kumar

Macey

et al. 2013

Journal of Cardiac Failure

View full text Add to dashboard Cite

Background Heart failure (HF) patients exhibit depressive and executive function impairments that contribute to HF mortality. Using specialized magnetic resonance imaging (MRI) analysis procedures, brain changes appear in areas regulating these functions (mammillary bodies, hippocampi, and frontal cortex). However, specialized MRI procedures are not part of standard clinical assessment for HF (which is usually a visual evaluation), and it is unclear whether visual examination can detect changes in these structures. Methods and Results Using brain MRI, we visually examined the mammillary bodies and frontal cortex for global and hippocampi for global and regional tissue changes in 17 HF and 50 control subjects. Significant global changes emerged in the right mammillary body (HF vs. control scores; 1.18±1.13 vs. 0.52±0.74; P=.024), right hippocampus (1.53±0.94 vs. 0.80±0.86; P=0.005), and left frontal cortex (1.76±1.03 vs. 1.24±0.77; P=0.034) between groups. Comparison of the visual method with specialized MRI techniques corroborates right hippocampal and left frontal cortical, but not mammillary body, atrophy. Conclusions Visual examination of brain MRI can detect damage in HF in areas regulating depression and executive function, including the right hippocampus and left frontal cortex. Visual MRI assessment may facilitate evaluation of injury to these structures and the assessment of the impact of potential treatments for this damage.

show abstract

Section: Discussionmentioning

confidence: 99%

Visual Assessment of Brain Magnetic Resonance Imaging Detects Injury to Cognitive Regulatory Sites in Patients With Heart Failure

Pan

Kumar

Macey

et al. 2013

Journal of Cardiac Failure

View full text Add to dashboard Cite

show abstract

“…Right hippocampal volumes were smaller in the high depression versus the low depression group, but there were no significant differences in left hippocampal volumes. Since in this study only female patients were included, and one recent study on familial depression with a sample including only female patients showed reduced volumes of the right but not the left hippocampus [21], the authors interpreted their finding as an indication for sex-specific associations between lateralized hippocampal atrophy and depression.…”

Section: Depressive Disordersmentioning

confidence: 99%

Morphostructural MRI Abnormalities Related to Neuropsychiatric Disorders Associated to Multiple Sclerosis

Bonavita

Tedeschi

Gallo

2013

Multiple Sclerosis International

View full text Add to dashboard Cite

Multiple Sclerosis associated neuropsychiatric disorders include major depression (MD), obsessive-compulsive disorder (OCD), bipolar affective disorder, euphoria, pseudobulbar affect, psychosis, and personality change. Magnetic Resonance Imaging (MRI) studies focused mainly on identifying morphostructural correlates of MD; only a few anecdotal cases on OCD associated to MS (OCD-MS), euphoria, pseudobulbar affect, psychosis, personality change, and one research article on MRI abnormalities in OCD-MS have been published. Therefore, in the present review we will report mainly on neuroimaging abnormalities found in MS patients with MD and OCD. All together, the studies on MD associated to MS suggest that, in this disease, depression is linked to a damage involving mainly frontotemporal regions either with discrete lesions (with those visible in T1 weighted images playing a more significant role) or subtle normal appearing white matter abnormalities. Hippocampal atrophy, as well, seems to be involved in MS related depression. It is conceivable that grey matter pathology (i.e., global and regional atrophy, cortical lesions), which occurs early in the course of disease, may involve several areas including the dorsolateral prefrontal cortex, the orbitofrontal cortex, and the anterior cingulate cortex whose disruption is currently thought to explain late-life depression. Further MRI studies are necessary to better elucidate OCD pathogenesis in MS.

show abstract

“…This issue is of particular importance in psychiatric diseases where the morphology of various brain regions is changed. MRI imaging studies identified a reduced hippocampal volume in females with depression 13 while smaller inferior frontal gyri of the dorsolateral prefrontal cortices were correlated with increased lifetime manic episodes in bipolar patients 14 . Using an optical dissector, Cotter et al demonstrated that neuronal but not oligodendroglial density was decreased in cortical layers 1 and 5 in bipolar and depression patients, 15 while Urnova et al found a reduction of oligodendroglial cells in schizophrenia, bipolar, and depression patients 16 .…”

Section: Introductionmentioning

confidence: 99%

A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression

2013

View full text Add to dashboard Cite

Brain cellular heterogeneity may bias cell type specific DNA methylation patterns, influencing findings in psychiatric epigenetic studies. We performed fluorescence activated cell sorting (FACS) of neuronal nuclei and Illumina HM450 DNA methylation profiling in post mortem frontal cortex of 29 major depression and 29 matched controls. We identify genomic features and ontologies enriched for cell type specific epigenetic variation. Using the top cell epigenotype specific (CETS) marks, we generated a publically available R package, “CETS,” capable of quantifying neuronal proportions and generating in silico neuronal profiles from DNA methylation data. We demonstrate a significant overlap in major depression DNA methylation associations between FACS separated and CETS model generated neuronal profiles relative to bulk profiles. CETS derived neuronal proportions correlated significantly with age in the frontal cortex and cerebellum and accounted for epigenetic variation between brain regions. CETS based control of cellular heterogeneity will enable more robust hypothesis testing in the brain.

show abstract

Reduced right posterior hippocampal volume in women with recurrent familial pure depressive disorder

Cited by 30 publications

References 63 publications

Visual Assessment of Brain Magnetic Resonance Imaging Detects Injury to Cognitive Regulatory Sites in Patients With Heart Failure

Visual Assessment of Brain Magnetic Resonance Imaging Detects Injury to Cognitive Regulatory Sites in Patients With Heart Failure

Morphostructural MRI Abnormalities Related to Neuropsychiatric Disorders Associated to Multiple Sclerosis

A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression

Contact Info

Product

Resources

About