Reduced retinal nerve fibre layer thickness in children with severe obesity

Pacheco-Cervera, J.; Codoñer‐Franch, Pilar; Simó-Jordá, Raquel; Pons-Vázquez, Sheila; Galbis-Estrada, Carmen; Pinazo-Durán, María Dolores

doi:10.1111/ijpo.12005

Cited by 27 publications

(31 citation statements)

References 31 publications

(49 reference statements)

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Section: Discussionmentioning

confidence: 99%

“…Obesity and MetS associated with chronic inflammation can affect most systems in the body (1,2,20). This chronic inflammation also has the potential to produce changes in the retina and macular layer (20). Indeed, previous MetS: metabolic syndrome studies have shown that obesity reduces the thickness of the retinal nerve fiber layer in children and affects choroid tissue (21,22,23).…”

Section: Discussionmentioning

confidence: 99%

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Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers

Öztürk¹,

Özen²,

Çatlı³

et al. 2020

Jcrpe

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Macular damage may be observed in obesity and metabolic syndrome (MetS), a condition which leads to chronic subclinical inflammation and affects most organ systems. To investigate the association between macular variability and anthropometric measurements, metabolic parameters, and inflammatory markers in children and adolescents with MetS. Methods: Two hundred and twenty eyes of 62 obese and 48 healthy children and adolescents were examined. Bilateral macular retinal thickness (MRT) and macular retinal volume (MRV) were measured in all subjects using optical coherence tomography. Associations between mean MRT and mean MRV and age, auxological measurements including body mass index standard deviation scores (BMI-SDS) and waist circumference-SDS (WC-SDS), metabolic parameters and inflammatory parameters including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio and systemic immune-inflammatory index (SIII) were investigated. Results: No statistically significant difference was observed between the groups in terms of age or sex distribution (p>0.05). Mean MRT (r=-0.326, p=0.007) and MRV (r=-0.303, p=0.007) values in the obese group with MetS decreased as homeostasis model assessmentinsulin resistance (HOMA-IR) values increased. SIII values were higher in obese groups, but particularly in obese subject with MetS, compared to the control group (p=0.021). The decrease in mean MRT (r=-0.544, p=0.046) and MRV (r=-0.651, p=0.031) in the obese subjects with MetS was negatively correlated with NLR. Mean MRT and MRV decreased in all obese subjects as SIII increased (p<0.05). Conclusion: This is the first study to show that mean MRT and MRV values decrease as BMI-SDS, WC-SDS and HOMA-IR increase in obese children and adolescents with MetS. NLR and SIII may serve as markers of chronic inflammation in obese children with MetS associated with macular damage.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers

Öztürk¹,

Özen²,

Çatlı³

et al. 2020

Jcrpe

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“…The RNFL and the thickness of choroid tissue can be affected by obesity. Previous studies have shown that obesity causes a thinning in RNFL thickness in children (23,24). Low level systemic inflammation is known to occur in obesity (25)(26)(27).…”

Section: Discussionmentioning

confidence: 97%

Does Obesity Affect the Ocular Choroid Tissue in Children and Adolescents?

Özen¹,

Öztürk²,

Çatlı³

et al. 2018

jpr

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Aim: Obesity may cause microangiopathic changes associated with the inflammatory process. The choroid tissue of the eye is one of the most highly vascularized tissues of body and supplies the outer 1/3 of the retina. Thinning in choroid tissue is an indicator of damage. Few studies have investigated obesity-induced choroid tissue damage in children, and their findings are inconsistent. The purpose of this study was to investigate changes in choroid tissue thickness in non-diabetic children and adolescents using optic coherence tomography (OCT) and the association with metabolic risk factors. Materials and Methods: One hundred fifty-six eyes of 38 obese and 40 healthy children and adolescents aged 10-18 were included in the study. The bilateral choroidal thicknesses were measured. We then investigated correlations between choroidal thickness and age, body measurements, pubertal stages, systolic and diastolic blood pressures, homeostasis model assessment insulin resistance and lipid values. Results: Mean choroidal thicknesses measured using OCT were 284.4±34.9 µm in the obese group and 316.3±39.7 µm in the control group (p=0.018). Choroidal thickness in the obese group decreased as body mass index (BMI) standard deviation scores (SDS) increased (r=-0.390, p=0.000). Conclusion: Mean choroidal thickness was lower in obese children and adolescents in this study compared to the healthy controls and thinning in the choroid tissue was more pronounced as BMI-SDS values increased. Increased adipose tissue may result in a susceptibility to damage by thinning choroid tissue.

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“…The recent reports demonstrated that the central corneal thickness and intraocular pressure were increased while as mean thickness of RNFL and retinal ganglion cell and choroidal thickness (CT) were decreased in the morbidly obese subjects [17][18][19]. However, another study has reported that CT increased in obese children [20].…”

Section: Editorialmentioning

confidence: 99%