Reduced resting-state brain functional network connectivity and poor regional homogeneity in patients with CADASIL

Su, Jingjing; Ban, Shiyu; Wang, Mengxing; Hua, Fang; Wang, Liang; Cheng, Xin; Tang, Yuping; Zhou, Houguang; Yu, Zhengquan; Du, Xiaoxia; Liu, Jian-Ren

doi:10.1186/s10194-019-1052-6

Cited by 13 publications

(11 citation statements)

References 50 publications

(55 reference statements)

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“…Among them, FPN plays a vital role in spatial attention and motion control, such as target-oriented hand and eye movement (69), which are exactly what the Tai Chi Chuan exercise requires. What's more, as shown in Table 3, enhancing the FC of the bilateral cuneus in VN by Tai Chi Chuan was more effective in CFS patients, related to visual information processing and visuomotor planning (70). Consequently, we speculate that the change in the causal relationship between RFPN and VN is the neural basis for Tai Chi Chuan to improve the cognitive function of CFS patients, especially visual-spatial attention.…”

Section: Discussionmentioning

confidence: 75%

Altered Effective Connectivity of Resting-State Networks by Tai Chi Chuan in Chronic Fatigue Syndrome Patients: A Multivariate Granger Causality Study

et al. 2022

Front. Neurol.

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Numerous evidence has shown that patients with chronic fatigue syndrome (CFS) have changes in resting brain functional connectivity, but there is no study on the brain network effect of Tai Chi Chuan intervention in CFS. To explore the influence of Tai Chi Chuan exercise on the causal relationship between brain functional networks in patients with CFS, 21 patients with CFS and 19 healthy controls were recruited for resting-state functional magnetic resonance imaging (rs-fMRI) scanning and 36-item Short-Form Health Survey (SF-36) scale assessment before and after 1month-long training in Tai Chi Chuan. We extracted the resting brain networks using the independent component analysis (ICA) method, analyzed the changes of FC in these networks, conducted Granger causality analysis (GCA) on it, and analyzed the correlation between the difference causality value and the SF-36 scale. Compared to the healthy control group, the SF-36 scale scores of patients with CFS were lower at baseline. Meanwhile, the causal relationship between sensorimotor network (SMN) and default mode network (DMN) was weakened. The above abnormalities could be improved by Tai Chi Chuan training for 1 month. In addition, the correlation analyses showed that the causal relationship between SMN and DMN was positively correlated with the scores of Role Physical (RP) and Bodily Pain (BP) in CFS patients, and the change of causal relationship between SMN and DMN before and after training was positively correlated with the change of BP score. The findings suggest that Tai Chi Chuan is helpful to improve the quality of life for patients with CFS. The change of Granger causality between SMN and DMN may be a readout parameter of CFS. Tai Chi Chuan may promote the functional plasticity of brain networks in patients with CFS by regulating the information transmission between them.

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Section: Discussionmentioning

confidence: 75%

Altered Effective Connectivity of Resting-State Networks by Tai Chi Chuan in Chronic Fatigue Syndrome Patients: A Multivariate Granger Causality Study

et al. 2022

Front. Neurol.

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“…Several studies have demonstrated the brain alterations in functional and structural imaging parameters in CADASIL patients. Our resting-state functional MRI (fMRI) studies showed that altered functional activity and connectivity in PCC/PCU and para-hippocampal cortex (PHC) were associated with cognitive impairment in CADASIL [11,12]. Diffusion tensor imaging (DTI) studies have demonstrated widespread white matter lesions associated with cognitive de cits in CADASIL [13][14][15].…”

Section: Introductionmentioning

confidence: 94%

Altered Default Mode Network Is Associated With Cognitive Impairment in Cadasil as Revealed by Multimodal Neuroimaging

Huang

Ban

et al. 2021

Preprint

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Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) caused by mutations in NOTCH3 gene is a hereditary cerebral small vessel disease, manifesting with stroke, cognitive impairment and mood disturbances. Functional or structural changes in the default mode network (DMN), which plays important roles in cognitive and mental maintenance, have been found in a number of neurological and mental diseases. However, it is still unclear whether DMN is altered in CADASIL patients.Methods: Multimodal imaging methods, including magnetic resonance imaging (MRI) and positron emission tomography (PET), were applied to evaluate the functional, structural and metabolic characteristics of DMN in 25 CADASIL patients and 42 healthy controls.Results: Compared to controls, CADASIL patients had decreased nodal efficiency and degree centrality of the dorsal medial prefrontal cortex and hippocampal formation within DMN. Structural MRI and diffusion tensor imaging (DTI) showed decreased gray matter volume and fiber tracks presented in the bilateral hippocampal formation. Meanwhile, PET imaging showed decreased metabolism within the whole DMN in CADASIL. Furthermore, correlation analyses showed that these nodal characteristics, gray matter volume, and metabolic signals of DMN were related to cognitive scores in CADASIL.Conclusions: Our results suggested that altered network characteristics of DMN may play important roles in cognitive deficits of CADASIL.

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“…For example, in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, impaired cognitive function has been related to decreased intranetwork connectivity and reduced local brain activity. 53 Hypothesis-testing candidate gene approaches-querying associations between variants in specific genes and clinical traits-have also been used to explore possible genetic associations. Genes that have received interest include BDNF (brain-derived growth factor) and its rs6265 Val66Met variant (Table I in the Data Supplement), APOE (Apolipoprotein E), VEGF (vascular endothelial growth factor), COX-1 (cyclooxygenase-1), and COX-2 (cyclooxygenase-2).…”

Section: Using Genetics To Explore Mechanisms Underlying Stroke Outcomementioning

confidence: 99%

Using Human Genetics to Understand Mechanisms in Ischemic Stroke Outcome: From Early Brain Injury to Long-Term Recovery

Fernández‐Cadenas²,

Lindgren

2021

Stroke

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There is a critical need to elucidate molecular mechanisms underlying brain injury, repair, and recovery following ischemic stroke—a global health problem with major social and economic impact. Despite 5 decades of intensive research, there are no widely accepted neuroprotective drugs that mitigate ischemic brain injury, or neuroreparative drugs, or personalized approaches that guide therapies to enhance recovery. We here explore novel reverse translational approaches that will complement traditional forward translational methods in identifying mechanisms relevant to human stroke outcome. Although genome-wide association studies have yielded over 30 genetic loci that influence ischemic stroke risk, only a few genome-wide association studies have been performed for stroke outcome. We discuss important considerations for genetic studies of ischemic stroke outcome—including carefully designed phenotypes that capture injury/recovery mechanisms, anchored in time to stroke onset. We also address recent genome-wide association studies that provide insight into mechanisms underlying brain injury and repair. There are several ongoing initiatives exploring genomic associations with novel phenotypes related to stroke outcome. To improve the understanding of the genetic architecture of ischemic stroke outcome, larger studies using standardized phenotypes, preferably embedded in standard-of-care measures, are needed. Novel techniques beyond genome-wide association studies—including exploiting informatics, multi-omics, and novel analytics—promise to uncover genetic and molecular pathways from which drug targets and other new interventions may be identified.

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Reduced resting-state brain functional network connectivity and poor regional homogeneity in patients with CADASIL

Cited by 13 publications

References 50 publications

Altered Effective Connectivity of Resting-State Networks by Tai Chi Chuan in Chronic Fatigue Syndrome Patients: A Multivariate Granger Causality Study

Altered Effective Connectivity of Resting-State Networks by Tai Chi Chuan in Chronic Fatigue Syndrome Patients: A Multivariate Granger Causality Study

Altered Default Mode Network Is Associated With Cognitive Impairment in Cadasil as Revealed by Multimodal Neuroimaging

Using Human Genetics to Understand Mechanisms in Ischemic Stroke Outcome: From Early Brain Injury to Long-Term Recovery

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