Reduced responsiveness of cutaneous microcirculation in essential hypertension – A pilot study

Lindstedt, Isak; Edvinsson, Marie-Louise; Edvinsson, Lars

doi:10.1080/08037050600996586

Cited by 38 publications

(32 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although we found local lines with slopes equal to 1, these lines did not shift in parallel in both anatomical locations; volar region and gaiter area. These findings suggest that the local vascular functions are impaired in volar region and in gaiter area in EHT patients and are in agreement with the finding of existing literature (1)(2)(3)(4)(5)(6). Under pathological condition such as EHT, remodeling can eventually compromise vessel elasticity.…”

Section: Local Regionsupporting

confidence: 92%

“…In the last two decade, studies on human cutaneous circulation have provided extensive data to assess microvascular function in a variety of vascular disease states including hypertension (1)(2)(3)(4)(5)(6). Although the skin blood flow measured from the volar region of the forearm has been commonly used to assess microvascular function in humans, the gaiter area (proximal to the medial malleolus) in the leg can also be used as an appropriate measurement site in some specific diseases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparative study of the upper and lower limb skin blood flow control mechanisms in patients with essential hypertension

Esen¹,

Ata²,

Esen³

2013

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

Objective: To investigate limb specific differences in cutaneous vascular function in patients (n=33) with essential hypertension (EHT). Methods: In this observational cross-sectional study, baseline skin blood flow and the response to local heating were measured with a laser Doppler flowmeter (LDF) from the volar region of the forearm and the gaiter area of the foot at supine rest. The fractal analysis, detrended fluctuation analysis (DFA), was used to calculate the correlation properties of skin blood flow, LDF signal. The paired t-test and repeated measures ANOVA were used to determine the response to local heating and compare the scaling exponents of different anatomical locations respectively. Results: We found three linear scaling regions that describe the fractal behavior of LDF signal with their slopes, scaling exponents. For cardiac (α C ) and cardio-respiratory (α CR ) scaling exponents, thermal hyperemia (T) induced greater change in the leg (α C =1.49±0.26; α CT =1.62±0.20 p<0.01 and α CR =0.84±0.29 α CRT =0.42±0.28 p<0.001) than in forearm (α C =1.28±0.13; α CT =1.33±0.13 p>0.05 and α CR =0.73±0.15; α CRT =0.65±0.018 p<0.05). Local scaling exponents (α L ≈α LT~1 ) were not significantly different (p>0.05) and, local lines did not shift in parallel with local heating in both extremities. Conclusion:The results of the present study suggest that skin microvascular function is impaired in both extremities in EHT patients. However, myogenic response is not uniform in both extremities and pronounced response to local thermal hyperemia has been observed in the gaiter area compared with the volar region. Further studies are needed to determine if these limb specific microvascular differences is the result of posture-induced structural and functional adaptation. (Anadolu Kardiyol Derg 2014; 14: 3-8)

show abstract

Section: Local Regionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Comparative study of the upper and lower limb skin blood flow control mechanisms in patients with essential hypertension

Esen¹,

Ata²,

Esen³

2013

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

show abstract

“…While the existence of a reduced responsiveness of the cutaneous microcirculation has already been demonstrated in EH patients [28], this study shows a similar deficit of the cutaneous blood flow in NP ADPKD patients.…”

Section: Discussionsupporting

confidence: 76%

Cutaneous Microcirculation Is Impaired in Early Autosomal Dominant Polycystic Kidney Disease

Ramunni¹,

Brescia²,

Quaranta³

et al. 2009

Nephron Clin Pract

View full text Add to dashboard Cite

Background/Aims: An endothelial dysfunction has been described in autosomal dominant polycystic kidney disease (ADPKD) before the development of hypertension and renal impairment. The aim of this work was to verify the existence of a microvascular reactivity in the early stages of ADPKD. Methods: Fifteen ADPKD normotensive patients with normal renal function underwent laser Doppler examination of the cutaneous microcirculation in basal conditions and after the warm test, as well as evaluation of plasma concentrations of some endothelial activation parameters [total cholesterol and fractions, fibrinogen, von Willebrand factor, Lp(a)]. The results were compared with those in 15 healthy subjects, 15 essential hypertensive patients and 15 hypertensive ADPKD patients with normal renal function. Results: Both basal and post-warm-test values were significantly lower in normotensive ADPKD subjects than controls (3.2 ± 1 vs. 5.8 ± 1.3 AU, p = 0.0001; 35.2 ± 10.9 vs. 50.5 ± 10.8 AU, p = 0.005, respectively). All evaluated parameters were within normal limits and comparable between normotensive ADPKD subjects and controls, except for LDL cholesterol (125 ± 18 vs. 101 ± 22 mg/dl, p = 0.01) and Lp(a), which was significantly higher in the ADPKD subjects (52.2 ± 36 vs. 6.0 ±4 mg/dl, p = 0.0006). Conclusion: Our study confirms the existence of a systemic microcirculation defect in ADPKD. The presence of high levels of Lp(a) could contribute to causing the high incidence of cardiovascular events in ADPKD.

show abstract

“…This result is in line with the hypothesis that the cardiovascular risk of OWH patients might be more favorable than that of their LH counterparts [134], as suggested by several [135,136], albeit not all [137] studies. In contrast with the present findings, the endothelium-independent microvascular reactivity has been reported to be preserved in adult hypertensives [98,99].…”

Section: Possible Mechanisms and Clinical Significance Of The Findingscontrasting

confidence: 99%

“…shown by attenuated LDF flux responses to occlusion of a limb and iontophoretic administration of vasodilators [98], or to local heating and iontophoresis [99], whereas the endothelium-independent function is preserved [98,99].…”

Section: Assessment Of the Microvasculaturementioning

confidence: 99%

Assessment of microvascular reactivity and oxidative stress in hypertensive adolescents and hemodialysis patients

Peter¹

View full text Add to dashboard Cite

Reduced responsiveness of cutaneous microcirculation in essential hypertension – A pilot study

Cited by 38 publications

References 26 publications

Comparative study of the upper and lower limb skin blood flow control mechanisms in patients with essential hypertension

Comparative study of the upper and lower limb skin blood flow control mechanisms in patients with essential hypertension

Cutaneous Microcirculation Is Impaired in Early Autosomal Dominant Polycystic Kidney Disease

Assessment of microvascular reactivity and oxidative stress in hypertensive adolescents and hemodialysis patients

Contact Info

Product

Resources

About