Reduced responsiveness of adenylate cyclase to forskolin in human lymphoma cells

Abstract

Abstract-The

Defects of β2‐adrenergic signal transduction in chronic lymphocytic leukaemia: relationship to disease progression

“…Recently, we have demonstrated that the function of the b 2 -AR complex is altered in low-grade non-Hodgkin's lymphomas (NHL). In particular, the cellular production of cAMP was decreased in mononuclear leucocytes (MNLs) from NHL patients [14]. This study extends these earlier observations and demonstrates that the impairment of the b 2 -AR complex in MNLs of CLL patients is correlated with disease progression, suggesting that a reduced cAMP production in response to specific external stimuli may be involved in disease progression of CLL.…”

“…In low-grade non-Hodkgin's lymphoma and in various other human malignancies, decreased cAMP levels were observed [13,26,27]. This is reflected by reduced numbers of b 2 -adrenergic receptors and a reduced cAMP production in response to catecholamine stimulation [14][15][16][17]. This is reflected by reduced numbers of b 2 -adrenergic receptors and a reduced cAMP production in response to catecholamine stimulation [14][15][16][17].…”

“…In CLL lymphocytes, both the density of b 2 -AR on the cell surface and the response to catecholamines are diminished [14][15][16][17]. In particular, the cellular production of cAMP was decreased in mononuclear leucocytes (MNLs) from NHL patients [14]. In particular, the cellular production of cAMP was decreased in mononuclear leucocytes (MNLs) from NHL patients [14].…”

“…The plasma, urine and intracellular cAMP levels were shown to be decreased in various malignancies, in particular in chronic lymphocytic leukaemia (CLL) [11][12][13][14]. In CLL lymphocytes, both the density of b 2 -AR on the cell surface and the response to catecholamines are diminished [14][15][16][17]. Recently, we have demonstrated that the function of the b 2 -AR complex is altered in low-grade non-Hodgkin's lymphomas (NHL).…”

Differential cAMP levels and serotonin effects in blood peripheral mononuclear cells and lymphocytes from major depression patients

“…In human lymphoma cells, there was a reduced response of beta-adrenergic receptors, also the authors indicated a reduction of protein G s and a reduction in the response to forskolin [17]. In lymphocytes of depressed patients, we found that there was a significant difference in the stimulation of adenylate cyclase by forskolin, which was reduced in the patients.…”