Reduced Red Cell Glycolysis, 2,3-Diphosphoglycerate and Adenosine Triphosphate Concentration, and Increased Hemoglobin-Oxygen Affinity Caused by Hypophosphatemia

Hypophosphatemia and recovery of post-hepatectomy liver insufficiency

“…This hypothesis is supported by canine models subjected to sub-total hepatectomy that led to rapid uptake of radiolabeled phosphate and increased mitotic counts in the regenerating residual liver, resulting in HP (18,19). Fluid shifts and high metabolic demand, characteristics of post-surgical state, may also exacerbate development of HP (33,34). Attributing post-hepatectomy HP to liver regeneration has been challenged by small studies identifying urinary waste with increased fractional urinary phosphate excretion paralleling the serum phosphate drop among 9 to 20 patients (35,36).…”

The Influence of Sodium Phosphate Supplementation on VO2max, Serum 2,3-diphosphoglycerate Level and Heart Rate in Off-road Cyclists

“…This may be confirmed by a low correlation between inorganic phosphate and resting level of 2,3-DPG obtained in this research (r=0,44; p=0,038). In general when the concentration of phosphates decreases a concomitant drop in 2,3-DPG occurs while the opposite is true when the serum level of (P) rises (Lichtman et al 1971, Card et al 1973. Not all research confirms this tendency.…”

HypophosphataemiaPathophysiology, effects and management on the intensive care unit

“…Therefore, phosphate diffuses out of the cell during hypophosphataemia and the resulting intracellular depletion of phosphate serves to inhibit glycolysis and activate adenosine 5 H -monophosphate deaminase. This may result in loss of 2,3-diphosphoglycerate (DPG) with a subsequent left shift of the oxygen dissociation curve [48]. In vitro studies of the effects of phosphate on the oxygen dissociation curve show that the addition of phosphate produces a right shift.…”

“…In addition to its effects on the ability of haemoglobin to carry oxygen, severe hypophosphataemia also increases the fragility of red cells [48]. This is due to impairment of ATP-dependent processes that are responsible for the maintenance of the shape and deformability of red blood cells.…”