Reduced Progression to Type 2 Diabetes From Impaired Glucose Tolerance After a 2-Day In-Hospital Diabetes Educational Program

Abstract

OBJECTIVE -We assessed the effects of a 2-day in-hospital diabetes educational program in preventing or delaying progression of impaired glucose tolerance (IGT) to type 2 diabetes, including analysis of changes in serum lipids, body weight, and blood pressure after the program. RESEARCH DESIGN AND METHODS-A total of 426 subjects (51 Ϯ 9 years, BMI 24.6 Ϯ 3.9 kg/m 2 ) with newly diagnosed IGT were randomly assigned to three groups, 143 as the short-term hospitalization with diabetes education and support (STH) group, 141 as the nonhospitalization but diabetes education and support (DES) group, and 142 as the neither hospitalization nor education (control) group.RESULTS -The average follow-up was 3.1 years. The incidence of diabetes was 8.0, 10.7, and 13.2 cases per 100 person-years for STH, DES, and control groups, respectively. The incidence of diabetes was 42% lower (95% CI 33-51%) in the STH group and 27% lower (15-37%) in the DES group than in the control group. The incidence of diabetes was 21% lower (10 -31%) in the STH group than in the DES group.CONCLUSIONS -The 2-day in-hospital program with diabetes education and support every 3 months was more effective in preventing or delaying the progression from IGT to diabetes than only diabetes education and support every 3 months.

Lifestyle Interventions for Adults with Impaired Glucose Tolerance: A Systematic Review and Meta-Analysis of the Effects on Glycemic Control

“…We identified nine RCTs that met our inclusion criteria (12)(13)(14)(15)(16)(17)(18)(19)(20). A flow diagram of this review is depicted in Fig.…”

“…After reading the full text of the 60 remaining arti- Table. The size of the participant population in each study varied from 78 to 577. Six studies (13,14,16,17,19,20) were conducted in Europe and three studies (12,15,18) were conducted in Asia. The mean age, diagnostic criteria, mean BMI, style of intervention and number of drop outs were compared between the studies.…”

“…Overall, the mean age was 54.3 years (range, 45 to 65), the mean BMI was 28.4 (range, 24.6 to 31.2, eight studies), the mean drop-out rate was 21.1% (range, 4.0 to 44.2%) and the mean followup was 58 months (range, 12 to 240). Six studies (12)(13)(14)(16)(17)(18) used the criteria defined by the WHO in 1985 (21), whereas two studies (19,20) used the criteria defined by the WHO in 2006 (22) and one study (15) used the glycogenic diagnostic criteria issued by the ADA in 2003 (23). None of the studies reported the incidence of progression to type 2 diabetes, while all studies reported the changes in the 2-hour plasma glucose and/or FPG levels from baseline to follow-up.…”

Japan Prevention Trial of Diabetes by Pitavastatin in Patients with Impaired Glucose Tolerance (the J-PREDICT study): rationale, study design, and clinical characteristics of 1269 patients

“…Annual incidence of new-onset diabetes is 2.1-13.2% according to past trials involving Japanese IGT patients [10][11][12]. In particular, the incidence of diabetes was 5.9% in the Japan Diabetes Prevention Program (JDPP) reported immediately prior to the initiation of J-PREDICT.…”

Rationale and design of Diabetes Prevention with active Vitamin D (DPVD): a randomised, double-blind, placebo-controlled study

“…3 The incidence of type 2 diabetes from pre-diabetes (impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT)) is about 10% (5.8-13.2%) per year. [4][5][6][7] While diabetes is an irreversible state, pre-diabetes can be reverted to a normal glucose state. Therefore, many clinical trials have aimed to reduce the incidence of type 2 diabetes by targeting individuals with pre-diabetes.…”