Reduced Prefrontal Hemodynamic Response in Pediatric Obsessive–Compulsive Disorder as Measured by Near-Infrared Spectroscopy

Ota, Toyosaku; Iida, Junzo; Sawada, Masayuki; Suehiro, Yuko; Yamamuro, Kazuhiko; Matsuura, Hiroki; Tanaka, Shohei; Kishimoto, Naoki; Negoro, Hiromitsu; Kishimoto, Toshifumi

doi:10.1007/s10578-012-0323-0

Cited by 20 publications

(26 citation statements)

References 41 publications

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“…Ota et al8 reported a smaller response in the frontopolar region in the pediatric OCD group, while Okada et al9 reported a smaller response in the left lateral prefrontal region in adult patients with OCD. In the present study, adult patients with OCD had significantly smaller changes in oxygenated hemoglobin concentrations than controls at channel 18, localized near the right lateral prefrontal region.…”

Section: Discussionmentioning

confidence: 98%

“…In an NIRS study, Ota et al8 and Okada et al9 showed that prefrontal hemodynamic responses were lower in both adult and pediatric patients with OCD using the Stroop color-word task, but that the areas with a reduced prefrontal hemodynamic response were different between these two populations. Ota et al8 reported a smaller response in the frontopolar region in the pediatric OCD group, while Okada et al9 reported a smaller response in the left lateral prefrontal region in adult patients with OCD.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, NIRS has been used to examine brain function in many psychiatric disorders, including schizophrenia, bipolar disorder, depression, dementia, post-traumatic stress disorder, pervasive developmental disorders, and attention deficit hyperactivity disorder. Ota et al8 and Okada et al9 recently used NIRS to examine OCD as measured during the Stroop color-word task and reported a reduced prefrontal hemodynamic response.…”

Section: Introductionmentioning

confidence: 99%

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Reduced dorsolateral prefrontal cortical hemodynamic response in adult obsessive-compulsive disorder as measured by near-infrared spectroscopy during the verbal fluency task

Hirosawa¹,

Narumoto²,

Nishida³

et al. 2013

NDT

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BackgroundNear-infrared spectroscopy has helped our understanding of the neurobiological mechanisms of psychiatric disorders and has advantages including noninvasiveness, lower cost, and ease of use compared with other imaging techniques, like functional magnetic resonance imaging. The verbal fluency task is the most common and well established task used to assess cognitive activation during near-infrared spectroscopy. Recent functional neuroimaging studies have shown that the orbitofrontal cortex and other brain regions, including the dorsolateral prefrontal cortex, may play important roles in the pathophysiology of obsessive-compulsive disorder (OCD). This study aimed to evaluate hemodynamic responses in the dorsolateral prefrontal cortex in patients with OCD using near-infrared spectroscopy during the verbal fluency task and to compare these with dorsolateral prefrontal cortex responses in healthy controls.MethodsTwenty patients with OCD and 20 controls matched for age, gender, handedness, and estimated intelligence quotient participated in this study. The verbal fluency task was used to elicit near-infrared spectroscopic activation and consisted of a 30-second pre-task, followed by three repetitions of a 20-second verbal fluency task (total 60 seconds), followed by a 70-second post-task period. The near-infrared spectroscopy experiment was conducted on the same day as surveys of obsessive-compulsive symptoms, depression, and anxiety. Z-scores for changes in the concentration of oxygenated hemoglobin were compared between the OCD patients and controls in 14 channels set over the left and right dorsolateral prefrontal cortex and frontopolar areas.ResultsDuring the verbal fluency task, significant task-related activation was detected in both the OCD group and the controls. Changes in oxygenated hemoglobin concentration in the right dorsolateral prefrontal cortex were significantly smaller in the OCD group than in the controls, but were not statistically significant after correction for multiple comparisons.ConclusionPatients with OCD have reduced prefrontal, especially right dorsolateral prefrontal, cortical hemodynamic responses as measured by near-infrared spectroscopy during the verbal fluency task. These results support the hypothesis that the dorsolateral prefrontal cortex plays a role in the pathophysiology of OCD.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reduced dorsolateral prefrontal cortical hemodynamic response in adult obsessive-compulsive disorder as measured by near-infrared spectroscopy during the verbal fluency task

Hirosawa¹,

Narumoto²,

Nishida³

et al. 2013

NDT

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“…Intellectual level was assessed using the Wechsler intelligence scale for children-fourth edition (WISC-IV), and individuals with full-scale IQ (FIQ) scores below 70 were excluded. We also excluded those who presented with a comorbid Axis I diagnosis, a neurological disorder, a head injury, a serious medical condition, or a history of substance abuse/dependence because these influenced the prefrontal hemodynamic response [20–22, 24, 26, 35, 36]. In total, 30 participants with ADHD who had no previous medication history were enrolled in the present study.…”

Section: Methodsmentioning

confidence: 99%

Differential therapeutic effects of atomoxetine and methylphenidate in childhood attention deficit/hyperactivity disorder as measured by near-infrared spectroscopy

Nakanishi

Ota

Iida

et al. 2017

Child Adolesc Psychiatry Ment Health

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BackgroundThe stimulant methylphenidate (MPH) and the nonstimulant atomoxetine (ATX) are the most commonly-prescribed pharmacological treatments for attention deficit/hyperactivity disorder (ADHD). However, the drug-specific mechanism of action on brain function in ADHD patients is not well known. This study examined differences in prefrontal hemodynamic activity between MPH and ATX in children with ADHD as measured by near-infrared spectroscopy (NIRS) using the Stroop color-word task.MethodsThirty children with ADHD participated in the present study. We used 24-channel NIRS (ETG-4000) to measure the relative concentrations of oxyhemoglobin in the frontal lobes of participants in the drug-naïve condition and those who had received MPH (n = 16) or ATX (n = 14) for 12 weeks. Measurements were conducted every 0.1 s during the Stroop color-word task. We used the ADHD RS-IV-J (Home Version) to evaluate ADHD symptoms.ResultsTreatment with either MPH or ATX significantly reduced ADHD symptoms, as measured by the ADHD RS-IV-J, and improved performance on the Stroop color-word task in terms of number of correct words. We found significantly higher levels of oxyhemoglobin changes in the prefrontal cortex of participants in the ATX condition compared with the values seen at baseline (pre-ATX). In contrast, we found no oxyhemoglobin changes between pre- and post-treatment with MPH.ConclusionsThe present study suggests that MPH and ATX have differential effects on prefrontal hemodynamic activity in children with ADHD.

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“…Nearinfrared spectroscopy: NIRS Fukuda, 2012NIRS Hirosawa et al, 2013Nakanishi et al, 2014;Okada et al, 2013;Ota et al, 2013;Takeda et al, 2017 Table 1 16…”

Section: Nirsmentioning

confidence: 99%

Hemodynamic Changes Using Near-Infrared Spectroscopy (NIRS) in Patients with Obsessive Compulsive Disorder

2017

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Reduced Prefrontal Hemodynamic Response in Pediatric Obsessive–Compulsive Disorder as Measured by Near-Infrared Spectroscopy

Cited by 20 publications

References 41 publications

Reduced dorsolateral prefrontal cortical hemodynamic response in adult obsessive-compulsive disorder as measured by near-infrared spectroscopy during the verbal fluency task

Reduced dorsolateral prefrontal cortical hemodynamic response in adult obsessive-compulsive disorder as measured by near-infrared spectroscopy during the verbal fluency task

Differential therapeutic effects of atomoxetine and methylphenidate in childhood attention deficit/hyperactivity disorder as measured by near-infrared spectroscopy

Hemodynamic Changes Using Near-Infrared Spectroscopy (NIRS) in Patients with Obsessive Compulsive Disorder

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