Reduced prefrontal activation during verbal fluency task in chronic insomnia disorder: a multichannel near-infrared spectroscopy study

Sun, Jui-Hung; Liu, Xiaomin; Shen, Chenyu; Zhang, Xiaoqian; Sun, Gang; Feng, Kun; Xu, Bo; Ren, Xiajin; Xl, Ma; Liu, Pozi

doi:10.2147/ndt.s136774

Cited by 26 publications

(19 citation statements)

References 65 publications

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“…Yet, various neuroimaging studies on brain areas associated with affective cognition suggest impairments in patients with insomnia (e.g. atrophic hippocampal substructures, see [28]; dysfunctional prefrontal activity, see [29]).…”

Section: Neuroimaging Studies On the Amygdalamentioning

confidence: 99%

Affect and Arousal in Insomnia: Through a Lens of Neuroimaging Studies

Schiel

Holub

Petri

et al. 2020

Curr Psychiatry Rep

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Purpose of Review Previous research has struggled with identifying clear-cut, objective counterparts to subjective distress in insomnia. Approaching this discrepancy with a focus on hyperarousal and dysfunctional affective processes, studies examining brain structures and neural networks involved in affect and arousal are reviewed and conclusions for an updated understanding of insomnia are drawn. Recent Findings Recent studies found that amygdala reactivity, morphometry and adaptation in insomnia are altered, indicating that processing of negative stimuli is intensified and more lasting. Also, patients with insomnia show aberrant connectivity in the default mode network (DMN) and the salience network (SN), which is associated with subjective sleep disturbances, hyperarousal, maladaptive emotion regulation and disturbed integration of emotional states. The limbic circuit is assumed to play a crucial role in enhanced recall of negative experiences. Summary There is reason to consider insomnia as a disorder of affect and arousal. Dysregulation of the limbic circuit might perpetuate impaired connectivity in the DMN and the SN. However, the interplay between the networks is yet to be researched.

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Section: Neuroimaging Studies On the Amygdalamentioning

confidence: 99%

Affect and Arousal in Insomnia: Through a Lens of Neuroimaging Studies

Schiel

Holub

Petri

et al. 2020

Curr Psychiatry Rep

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“…In a previous study, prefrontal cortical activation during VFT, assessed using fNIRS, was found to be reduced in chronic insomnia disorder. [ 30 ] The purpose of this study is to investigate the mechanism of action of YKSCH in patients with PD exhibiting sleep disorder, by confirming the hemodynamic changes in the frontal lobe caused by the administration of YKSCH.…”

Section: Discussionmentioning

confidence: 99%

“…[ 29 ] Hemodynamic responses, measured using fNIRS, during a VFT showed hypoactivation in the PFC of patients with chronic insomnia. [ 30 ] Therefore, our intention is to determine whether the concentrations of oxygenated hemoglobin in the PFC of patients with PD exhibiting sleep disorder is increased by YKSCH administration, using fNIRS during VFT. The test will be performed at baseline (visit 1) and after treatment (visit 4) in both groups.…”

Section: Methods and Designmentioning

confidence: 99%

Efficacy of Yokukansankachimpihange on sleep disturbance in Parkinson's disease

et al. 2018

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Introduction:Parkinson's disease (PD) is a progressive neurodegenerative disorder that includes motor and nonmotor symptoms. Sleep disturbance is known to decrease the quality of life in patients with PD, and there are limitations to the pharmacotherapy currently in use. Therefore, complementary treatment therapies are required to address these limitations. The traditional herbal medicines Yokukansan (YKS) and Yokukansankachimpihange (YKSCH) have been used to treat insomnia and night crying in children, suggesting their effectiveness against sleep disturbance in patients with PD. We will evaluate whether YKSCH improves sleep disturbance in PD and will identify YKS-related changes in hemodynamic parameters, and neurotransmitter and hormone levels in patients with PD experiencing sleep disturbance.Methods:We will conduct a randomized, double-blinded, placebo-controlled parallel trial in 34 patients with PD and sleep disturbance, randomly allocating the patients to either placebo-control (n = 17) or treatment groups (n = 17). The total study period will be 16 weeks; administration of YKSCH or placebo, as intervention, will be performed for a 12-week period, and follow-up will be performed over a 4-week period. All subjects will undergo conventional treatment, and be required to maintain a regular medication schedule throughout the study period. The primary outcome measure will be the Scales for Outcomes in PD-Sleep Scale score, and the secondary outcome measures will be polysomnography results, findings from instruments related to sleep disorders, neurotransmitter and hormone levels, and hemodynamic changes in the brain cortex.Discussion and conclusions:This trial will evaluate the effectiveness and safety of YKSCH for sleep improvement in PD with sleep disturbance, and investigate the underlying mechanism of action. We expect improvement in the scores for subjective and objective sleep scales, hemodynamic changes in prefrontal cortical activity, and changes in neurotransmitter and hormone levels. The findings will provide insight into the mechanism underlying the therapeutic effect of YKSCH in PD, and lay the foundation for further studies on whether YKSCH improves sleep disturbance in PD.Trial registration number:Clinical Research Information Service (KCT0002869).

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“…[39–41] Moreover, several studies have reported that this neural circuitry maybe sensitive to insomnia. [19,42–45] Previous studies have shown impaired decision-making ability in the IGT in participants with sleep deprivation, as evidenced by their increased number of choices from disadvantageous decks. [46,47] A recent study from Seeley et al [48] suggested that sleep improves strategy-decision learning ability in the IGT; these results provide new insights into the relationship between sleep and IGT learning.…”

Section: Introductionmentioning

confidence: 99%

“…[46,50] Previous studies have also confirmed functional abnormalities in the prefrontal cortex of patients with PI. [38,45] These functional abnormalities may underlie the significant cognitive deficits associated with PI, which may include deficits in emotional memory and decision-making. However, whether PI shows analogous outcomes in emotional memory and decision-making, similar to sleep deprivation, remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Impaired emotional memory and decision-making following primary insomnia

et al. 2019

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Previous studies have indicated that sleep plays an important role in emotional memory and decision-making. However, very little attention has been given to emotional memory and decision-making in patients with primary insomnia (PI). We investigated whether PI influences the accuracy of emotional memory and social decision-making. We examined 25 patients with PI and 20 healthy controls (HC) using an emotional picture memory task and the Iowa Gambling Task (IGT). In the emotional picture memory task, participants completed two testing sessions: an emotional picture evaluation and a delayed recognition phase. During the emotional picture evaluation phase, participants were presented with 48 pictures with different valence (16 positive, 16 neutral, and 16 negative), which they had to evaluate for emotional valence and arousal. During the recognition phase, participants were asked to make a yes/no memory assessment of a set of pictures, which contained the 48 target pictures intermingled with 48 non-target pictures. The performance of the participants with PI was the same as that of the HC in the emotional picture evaluation task. However, the PI group showed worse recognition of the positive and neutral pictures than did the HC group, although recognition of negative pictures was similar in the 2 groups. In the IGT, participants in the PI group more frequently selected cards from the risky decks as the game progressed and selected more disadvantageous cards than did participants in the HC group after the first block. Our findings suggest that insomnia had different effects on memory, depending on the valence of the memory. Specifically, memory performance was impaired for positive and neutral items, but the recognition of negative stimuli seemed to be more resistant to the effects of insomnia. Our results also suggest that decision-making, which is known to be mediated by the ventromedial prefrontal cortex, including decision-making under conditions of uncertainty, may be vulnerable in PI.

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Reduced prefrontal activation during verbal fluency task in chronic insomnia disorder: a multichannel near-infrared spectroscopy study

Cited by 26 publications

References 65 publications

Affect and Arousal in Insomnia: Through a Lens of Neuroimaging Studies

Affect and Arousal in Insomnia: Through a Lens of Neuroimaging Studies

Efficacy of Yokukansankachimpihange on sleep disturbance in Parkinson's disease

Impaired emotional memory and decision-making following primary insomnia

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