Reduced power and phase-locking values were accompanied by thalamus, putamen, and hippocampus atrophy in Parkinson's disease with mild cognitive impairment: an event-related oscillation study

Hünerli-Gündüz, Duygu; Özbek, Yağmur; Uzunlar, Hakan; Çavuşoğlu, Berrin; Çolakoğlu, Berril Dönmez; Ada, Emel; Güntekin, Bahar; Yener, Görsev

doi:10.1016/j.neurobiolaging.2022.10.001

Cited by 10 publications

(12 citation statements)

References 104 publications

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Section: Discussionsupporting

confidence: 93%

“…We showed BC and DC of left thalamus was significantly reduced in CI+ patients compared to CI-patients, indicating left thalamus was specifically impaired in CI+ patients. In agreement with our findings, left thalamus volume was found to be significantly reduced in CI+ patients [84]. Melief et al (2018) have demonstrated that deficiency of glutamate signaling from thalamus to dorsal striatum induced the impairment of processing speed in PD [85].…”

Section: The Key Nodes In Structural Network Associated With Pd-relat...supporting

confidence: 92%

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Structural network topology mediated cognitive impairment in Parkinson’s disease

Chen,

Li,

Zhou

et al. 2023

Preprint

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Cognitive impairment (CI) is one of the most prominent non-motor symptoms in Parkinson's disease (PD). How brain network abnormalities contribute to CI in PD patients remain largely unclear. The goal of this study is to explore whether aberrations of brain network topology were causally associated with cognitive decline in PD patients. PD patients receiving magnetic resonance imaging from Parkinson's Progression Markers Initiative (PPMI) database were specifically selected. According to the scores of Montreal Cognitive Assessment (MoCA), PD patients were classified into CI+ group (MoCA score ≤ 25) and CI- group (MoCA score > 25) to investigate whether clinical features and brain networks were significantly different between two groups. Mediation analysis was utilized to evaluate whether brain network alterations contributed to CI in PD patients. We revealed CI + group exhibited more severe non-motor symptoms compared to CI- group. In addition, age, excessive daytime sleepiness, and depressive symptoms were found to be significantly associated with CI of PD patients. Moreover, CI+ group exhibited statistically different local topological properties in structural network compared to CI- group. Furthermore, differential local topological metrics in structural network meditated the effects of age, excessive daytime sleepiness, and depression on cognitive decline of PD patients. Taken together, out study suggested that PD patients with CI exhibited notable disturbances of structural network topology, which mediated negative associations between of age, excessive daytime sleepiness, depression and cognitive decline of PD patients.

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Section: Discussionsupporting

confidence: 93%

Section: The Key Nodes In Structural Network Associated With Pd-relat...supporting

confidence: 92%

Structural network topology mediated cognitive impairment in Parkinson’s disease

Chen,

Li,

Zhou

et al. 2023

Preprint

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“…Many volumetric MRI studies have reported that GMV loss is evident in the temporal, parietal, frontal, occipital and limbic regions in PD-MCI and diffuse GMV loss in patients, who progress to the dementia phase [21][22][23][24][25]. It has been stated in previous studies that hippocampal volume loss is one of the most important factors predicting the development of mild cognitive impairment and dementia in Parkinson's disease [26][27][28][29]. It has been stated that hyperintensities in white matter affect the longitudinal cognitive status in PD [26,30,31].…”

Section: Discussionmentioning

confidence: 99%

Structural and Functional Changes in Mild Cognitive Impairment in Parkinson’s Disease

Güllüoğlu,

Hünerli,

Çakmur

et al. 2023

Medicina

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Background and Objectives: The pathophysiology of mild cognitive impairment in Parkinson’s disease (PD-MCI) is still not fully elucidated. It has been shown in a few studies in the literature that volume loss in the occipital, parietal and frontal cortices and atrophy in the hippocampus of PD-MCI patients can occur in the early stages of PD. The aim of this study was to evaluate the relationship between gray and white matter volumes and different neuropsychological tests and volumetric magnetic resonance imaging parameters in patients with mild cognitive impairment in Parkinson’s disease (PD-MCI). Materials and Methods: Twenty-six PD-MCI and twenty-six healthy elderly (HC) were included in this study. Results: We found that Mini Mental State Examination, Trail Making Test Part A, Clock Drawing Test, Benton Line Judgment Orientation Test and pentagon figure-copying scores were impaired in PD-MCI patients due to the decrease in brain volumes. Conclusions: Our study revealed that among PD-MCI patients, there was a more noticeable decline in White matter volume (WMV) based on volumetric Magnetic Resonance Imaging (MRI) compared to the localized loss of GMV. We think that these abnormal neuropsychological tests in PD-MCI patients can be used as pretests in the evaluation of the stage of transition to dementia.

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“…Meta-analysis showed consistent GM loss in bilateral medial temporal lobes and striatum [ 253 ]. PDD had lower hippocampal volumes than HCs without exhibiting any differences from PD-MCI [ 254 ]. Early-onset PDD patients exhibited more severe atrophy in the left anterior cingulate and right inferior temporal gyrus associated with a significant volume reduction in substantia innominata [ 255 ].…”

Section: Neuroimaging Findings In CI In Pd (See Supplement ...mentioning

confidence: 99%

Pathobiology of Cognitive Impairment in Parkinson Disease: Challenges and Outlooks

Jellinger

2023

IJMS

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Cognitive impairment (CI) is a characteristic non-motor feature of Parkinson disease (PD) that poses a severe burden on the patients and caregivers, yet relatively little is known about its pathobiology. Cognitive deficits are evident throughout the course of PD, with around 25% of subtle cognitive decline and mild CI (MCI) at the time of diagnosis and up to 83% of patients developing dementia after 20 years. The heterogeneity of cognitive phenotypes suggests that a common neuropathological process, characterized by progressive degeneration of the dopaminergic striatonigral system and of many other neuronal systems, results not only in structural deficits but also extensive changes of functional neuronal network activities and neurotransmitter dysfunctions. Modern neuroimaging studies revealed multilocular cortical and subcortical atrophies and alterations in intrinsic neuronal connectivities. The decreased functional connectivity (FC) of the default mode network (DMN) in the bilateral prefrontal cortex is affected already before the development of clinical CI and in the absence of structural changes. Longitudinal cognitive decline is associated with frontostriatal and limbic affections, white matter microlesions and changes between multiple functional neuronal networks, including thalamo-insular, frontoparietal and attention networks, the cholinergic forebrain and the noradrenergic system. Superimposed Alzheimer-related (and other concomitant) pathologies due to interactions between α-synuclein, tau-protein and β-amyloid contribute to dementia pathogenesis in both PD and dementia with Lewy bodies (DLB). To further elucidate the interaction of the pathomechanisms responsible for CI in PD, well-designed longitudinal clinico-pathological studies are warranted that are supported by fluid and sophisticated imaging biomarkers as a basis for better early diagnosis and future disease-modifying therapies.

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Reduced power and phase-locking values were accompanied by thalamus, putamen, and hippocampus atrophy in Parkinson's disease with mild cognitive impairment: an event-related oscillation study

Cited by 10 publications

References 104 publications

Structural network topology mediated cognitive impairment in Parkinson’s disease

Structural network topology mediated cognitive impairment in Parkinson’s disease

Structural and Functional Changes in Mild Cognitive Impairment in Parkinson’s Disease

Pathobiology of Cognitive Impairment in Parkinson Disease: Challenges and Outlooks

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