Reduced Physical Activity Patterns In Patients With Thalassemia Compared To Healthy Controls

Fung, Ellen B.; Pinal, Jennifer; Leason, Michelle

doi:10.14302/issn.2372-6601.jhor-15-776

Cited by 6 publications

(8 citation statements)

References 35 publications

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“…Additionally, pain in all body contributes to difficult in walking, running as well as doing light chores in home. The findings of Fung et al, (2015) (14) were congruent with present study who found that those children had reduced physical activities.…”

Section: Discussionsupporting

confidence: 92%

“…Thalassemia is a chronic disease that presents a range of serious physical challenges as bone deformity, growth retardation, delayed puberty, short stature as well as poor self-image (13) . So, those children are presumed to be inactive (14) .The findings of the present study reflected that almost two thirds of the children had problems with usual physical activities and self-care which was supported by the findings reported by their parents. These results could be related to the regular period of mild anemia just prior to scheduled blood transfusion that limits their exercises capacity.…”

Section: Discussionsupporting

confidence: 86%

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Quality Of Life of Children with Thalassemia in Alexandria

Mahmoud

Helaly

Mohammed

et al. 2019

Alexandria Scientific Nursing Journal

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 86%

Quality Of Life of Children with Thalassemia in Alexandria

Mahmoud

Helaly

Mohammed

et al. 2019

Alexandria Scientific Nursing Journal

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“…Anemia is known to contribute to poor appetite, and the slower rate of growth may also be related to higher rates of resting energy expenditure (and thus higher calorie/kg need) and a low hemoglobin level in the days preceding routine transfusions . However, overall energy expenditure may not be a significant drain, given a reduction in physical activity patterns . In toddlers, especially, parents may struggle with balancing adequate nutrition with a child's food preferences.…”

Section: Growth Deficiencymentioning

confidence: 99%

The importance of nutrition for health in patients with transfusion‐dependent thalassemia

Fung

2016

Annals of the New York Academy of Sciences

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Nutrition is increasingly being seen by care providers as important for patients with thalassemia. However, the definition of optimal nutritional support and the means to provide that support remain elusive. This review focuses on the relationships between nutritional status and three common comorbidities in patients with thalassemia: low bone mass, growth deficiency, and diabetes. The association between low bone mass and specific nutrient deficiencies (e.g., vitamin D, zinc) is clear, while the role of nutritional adequacy for young patients with growth deficiencies requires careful analysis to distinguish it from chronic anemia and endocrine insufficiency. Correction of isolated nutritional deficiencies in small cohorts of patients with thalassemia has shown some promise at improving both bone health and linear growth in the short term. However, the long-term safety and acceptability of these practices need to be evaluated. On the whole, there are few well-designed, adequately powered studies of the role of general dietary or specific micronutrients in the cause, treatment, or prevention of these commonly observed morbidities in thalassemia. Until these data are gathered, it is suggested that patients with thalassemia be monitored frequently and that their nutritional deficiencies be corrected when observed in order to advance their overall health and quality of life.

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“…Reduced total caloric intake is also frequently observed in individuals with Thal, purportedly related to small stature [6] and reduced physical activity [7]. Decreased caloric consumption may increase the risk of nutritional deficits if an individual consumes a significant amount of “empty calories”, or foods with little nutritional value.…”

Section: Introductionmentioning

confidence: 99%

Nutritional Deficiencies Are Common in Patients with Transfusion-Dependent Thalassemia and Associated with Iron Overload

Goldberg¹,

Neogi²,

Lal³

et al. 2018

JFNR

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Patients with thalassemia are frequently deficient in key micronutrients. Attempts to correct these inadequacies through nutritional supplementation have been met with some success, although disparities between intake and circulating levels continue to be observed. This study employed a convenience sample of 41 well-nourished transfusion dependent patients with thalassemia to identify possible mechanisms behind nutritional deficiencies. Each subject completed a Block 2005© Food Frequency Questionnaire (FFQ), through which macro and micronutrient intake was quantified. Fasting blood was drawn to assess vitamins A, C, D, E, copper, selenium, zinc and hematologic parameters. Dietary intake was found to be inadequate compared to Institute of Medicine (IOM) recommendations for many of the fat-soluble vitamins, as well as calcium and zinc. Circulating deficiencies of vitamins C, D, copper, zinc and γ tocopherol were also present in over 20% of patients. Many individuals who consumed an adequate dietary intake had deficient levels of circulating nutrients, which suggest alternative etiologies of nutrient excretion or loss, in addition to higher micronutrient requirements. Liver iron concentration displayed a significant negative relationship with vitamins C (r=−0.62, p<0.001), E (r=−0.37, p=0.03), and zinc (r=−0.35, p=0.037), indicating that in iron-overloaded patients, these nutrients are either endogenously consumed at higher rates or sequestered within the liver, resulting in a functional nutrient deficiency. While this study identified hepatic iron overload to be a significant cause of nutritional deficits commonly observed in patients with thalassemia, multiple etiologies are simultaneously responsible. In response to these findings, nutritional status should be monitored regularly in at-risk patients with thalassemia, and prophylactically addressed with supplementation or aggressive chelation to avoid associated co-morbidities.

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Reduced Physical Activity Patterns In Patients With Thalassemia Compared To Healthy Controls

Abstract: Background: Patients with Thal (Thalassemia) are presumed to be inactive for many of the same

Cited by 6 publications

References 35 publications

Quality Of Life of Children with Thalassemia in Alexandria

Quality Of Life of Children with Thalassemia in Alexandria

The importance of nutrition for health in patients with transfusion‐dependent thalassemia

Nutritional Deficiencies Are Common in Patients with Transfusion-Dependent Thalassemia and Associated with Iron Overload

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