Reduced paralimbic system gray matter volume in schizophrenia: Correlations with clinical variables, symptomatology and cognitive function

Liao, Jinmin; Yan, Hao; Liu, Qi; Yan, Junhao; Zhang, Lanlan; Jiang, Sisi; Zhang, Xiao; Dong, Zheng; Yang, Wen Bin; Cai, Liwei; Guo, Hong; Wang, Yan; Li, Zimeng; Tian, Lin; Zhang, Dai; Wang, Fei

doi:10.1016/j.jpsychires.2015.04.008

Cited by 29 publications

(22 citation statements)

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“…The neurodegeneration is likely the only one aspect of structural variability in people with schizophrenia. Schizophrenia-related brain structural damages are markedly correlated with not only cognitive function deficits but also positive psychotic symptoms [ 39 ]. More specifically, people with schizophrenia exhibit widespread reductions of both GMD [ 40 , 41 ] and gray matter volume (GMV) [ 40 , 42 – 45 ] in many brain regions, including the GMD reduction in the occipito-tempro-frontal circuitry, which underlies both visual information and eye movement processing [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…The RSS deficits in people with schizophrenia are significantly associated with GMD reductions in the occipital, temporal, and frontal regions underlying both visual information and eye movement processing [ 12 , 34 ]. On the other hand, in people with schizophrenia the hallucination severity is also associated with the GMV alternations in the parietal, temporal, frontal, and paralimbic systems [ 39 , 44 , 49 – 52 ]. In addition to schizophrenia-related GMD, it is also of importance and interest to know whether the schizophrenia-related GMV are associated with the schizophrenia-related RSS.…”

Section: Introductionmentioning

confidence: 99%

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Correlations between exploratory eye movement, hallucination, and cortical gray matter volume in people with schizophrenia

et al. 2018

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BackgroundWidespread cortical gray matter alternations in people with schizophrenia are correlated with both psychotic symptoms and cognitive/behavioral abnormalities, including the impairments of exploratory eye movement (EEM). Particularly, the loss of gray matter density is specifically related to deficits of the responsive search score (RSS) of EEM in schizophrenia. It is unknown, however, whether the schizophrenia-related RSS deficits are associated with certain psychotic symptoms, such as hallucinations.MethodsIn 33 participants with schizophrenia, the measurement of EEM, assessment of the hallucination severity using Positive and Negative Syndrome Scale (PANSS) and a voxel-based morphometric analysis of cortical gray matter volume (GMV) were conducted to investigate the relationships between the RSS of EEM, symptom severity, and GMV. In 29 matched healthy controls, the measurement of EEM and a voxel-based morphometric analysis of cortical GMV were also conducted to investigate the relationship between the RSS of EEM and GMV.ResultsIn participants with schizophrenia, the hallucination severity was significantly negatively correlated with both the RSS and the GMV of a large number of brain regions in the frontal, temporal, parietal, orbitofrontal, calcarine, cingulate, and insular cortices, and rolandic operculum, hippocampus, parahippocampal gyrus, and thalamus. Also in participants with schizophrenia, the RSS was significantly positively correlated with the GMV in the left supplementary motor area (SMA), left superior frontal cortex (SFG), bilateral precentral gyri, bilateral postcentral gyri, and bilateral middle frontal cortices. More importantly, the GMV of the SMA, SFG, and precentral gyrus in the left hemisphere was not only significantly negatively correlated with the hallucination severity but also significantly positively correlated with the RSS. No significant correlation could be revealed between the RSS and the GMV of any brain regions in healthy controls.ConclusionsThere was a significantly negative association between the hallucination severity and the RSS of EEM, suggesting that the RSS may be a potential biomarker for predicting the hallucination severity of schizophrenia. Also, the GMV of the left SMA, SFG, and precentral gyrus may be the common substrates underlying both hallucination induction and the RSS in people with schizophrenia.Electronic supplementary materialThe online version of this article (10.1186/s12888-018-1806-8) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlations between exploratory eye movement, hallucination, and cortical gray matter volume in people with schizophrenia

et al. 2018

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“…Yet some studies have shown that antipsychotic treatment has an incremental effect on the caudate, thalamus, and parts of the frontal and temporal parietal lobule, with a significant grey matter reduction in parts of the frontal gyrus [ 11 , 12 ]. Another factor that may affect GMV is the duration of illness, i.e., a greater GMV reduction is associated with a longer duration, and this has been validated by many studies [ 13 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

Progressive Grey Matter Volume Changes in Patients with Schizophrenia over 6 Weeks of Antipsychotic Treatment and Their Relationship to Clinical Improvement

Zhang

Liao

et al. 2018

Neurosci. Bull.

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Cross-sectional and longitudinal studies have identified widespread and progressive grey matter volume (GMV) reductions in schizophrenia, especially in the frontal lobe. In this study, we found a progressive GMV decrease in the rostral medial frontal cortex (rMFC, including the anterior cingulate cortex) in the patient group during a 6-week follow-up of 40 patients with schizophrenia and 31 healthy controls well-matched for age, gender, and education. The higher baseline GMV in the rMFC predicted better improvement in the positive score on the Positive and Negative Syndrome Scale (PANSS), and this might be related to the improved reality-monitoring. Besides, a higher baseline GMV in the posterior rMFC predicted better remission of general symptoms, and a lesser GMV reduction in this region was correlated with better remission of negative symptoms, probably associated with ameliorated self-referential processing and social cognition. Besides, a shorter disease course and higher educational level contributed to better improvement in the general psychopathological PANSS score, and a family history was negatively associated with improvement of the negative and total PANSS scores. These phenomena might be important for understanding the neuropathological mechanisms underlying the symptoms of schizophrenia and for making clinical decisions.

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“…Specifically, limbic system and paralimbic system participate in formation and maintenance of anxiety associated with FXS which mainly involve amygdala, prefrontal cortex (PFC), insula, cingulate cortex, temporal cortex, and hippocampus, etc. [ 6 ]. Up to now, among all relevant encephalic regions, amygdala–insula is found to be the location where 5-HTTLPR (5-hydroxytryptamine transporter linked polymorphic region) might cause anxiety [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome

Yang

Zhao

et al. 2016

Neural Plasticity

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Fragile X syndrome (FXS) is an inheritable neuropsychological disease caused by expansion of the CGG trinucleotide repeat affecting the fmr1 gene on X chromosome, resulting in silence of the fmr1 gene and failed expression of FMRP. Patients with FXS suffer from cognitive impairment, sensory integration deficits, learning disability, anxiety, autistic traits, and so forth. Specifically, the morbidity of anxiety in FXS individuals remains high from childhood to adulthood. By and large, it is common that the change of brain plasticity plays a key role in the progression of disease. But for now, most studies excessively emphasized the one-sided factor on the change of synaptic plasticity participating in the generation of anxiety during the development of FXS. Here we proposed an integrated concept to acquire better recognition about the details of this process.

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Reduced paralimbic system gray matter volume in schizophrenia: Correlations with clinical variables, symptomatology and cognitive function

Cited by 29 publications

References 48 publications

Correlations between exploratory eye movement, hallucination, and cortical gray matter volume in people with schizophrenia

Correlations between exploratory eye movement, hallucination, and cortical gray matter volume in people with schizophrenia

Progressive Grey Matter Volume Changes in Patients with Schizophrenia over 6 Weeks of Antipsychotic Treatment and Their Relationship to Clinical Improvement

Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome

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