Reduced Pain with Use of Proprietary Hyaluronic Acid with Lidocaine for Correction of Nasolabial Folds: A Patient-Blinded, Prospective, Randomized Controlled Trial

Abstract

Addition of lidocaine to a filler resulted in significantly less pain associated with the procedure without compromising outcomes.

Hyaluronic acid dermal fillers: can adjunctive lidocaine improve patient satisfaction without decreasing efficacy or duration?

“…Collagen dermal fillers were introduced to the United States market in the 1980s followed by HA fillers in the 1990s 4,9. HA is a transparent, highly refractile molecule that derives its name from the Greek term ‘hyalos’ meaning glass.…”

“…Decreased collagen production, loss of elastin, muscle hyperactivity, atrophy of bone, and soft tissue structure lead to aging changes in the face. These are heralded by skin laxity and volumetric loss and redistribution 2–4. For deep facial wrinkles, dermal fillers have the unique ability over botulinum toxin injection and surgical tightening procedures to augment tissue volume.…”

“…HA dermal fillers meet this demand in many ways and have a lower risk of allergic reaction compared to previously used collagen fillers 6,7. Their greatest future obstacles are pain management and duration of action 2–4,6–8. This article reviews previous studies that compare pain management with and without adjunct lidocaine and the adverse effects of HA dermal fillers and those unique to fillers with adjunct lidocaine.…”

Hyaluronic Acid Dermal Fillers: Safety and Efficacy for the Treatment of Wrinkles, Aging Skin, Body Sculpturing and Medical Conditions

“…The outcome was not different. 61 A single-centered, double-blinded, randomized, with-in patient trial, compared patient comfort when receiving HA injections versus injections of HA mixed with lidocaine hydrochloride 2% (HA + L). Eighteen females were enrolled and completed the study.…”

A Randomized Clinical Trial to Evaluate the Efficacy and Safety of Lidocaine-Containing Monophasic Hyaluronic Acid Filler for Nasolabial Folds

“…4 Therefore, more hyaluronic acid fillers are now incorporating lidocaine to reduce injection discomfort. [4][5][6][7][8][9][10] There are several studies comparing hyaluronic acid fillers with lidocaine versus those without lidocaine [5][6][7][8][9][10] ; however, to our knowledge, no recent studies have been conducted to compare two different hyaluronic acid fillers that both contain lidocaine.…”