Reduced paediatric hospitalizations for malaria and febrile illness patterns following implementation of community-based malaria control programme in rural Rwanda

Sievers, Amy; Lewey, Jennifer; Musafiri, Placide; Franke, Molly F.; Bucyibaruta, Blaise J; Stulac, Sara; Rich, Michael; Karema, Corine; Daily, Johanna P.

doi:10.1186/1475-2875-7-167

Cited by 34 publications

(34 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also malaria prevalence in children under five years of age decreased in Rwanda after the implementation of a programme that provided ACT and LLINs [14]. In the current study, fever, any parasitaemia, 75 different historical situations in which malaria resurged after it had been controlled [34].…”

Section: Discussionmentioning

confidence: 54%

“…Tropical Africa has generally been identified as having a high coverage of combined malaria control interventions [12] [13]. Findings from malaria control programs using LLINs, ACT or IRS have shown a drastic decline in malaria deaths, malaria positive cases and malaria prevalence over the past decade [14] [15] [16]. Furthermore, the scale-up of LLINs and ACT use in case management has reduced the burden of malaria anaemia in children under five years of age [14] [17].…”

Section: Advances In Infectious Diseasesmentioning

confidence: 99%

“…Findings from malaria control programs using LLINs, ACT or IRS have shown a drastic decline in malaria deaths, malaria positive cases and malaria prevalence over the past decade [14] [15] [16]. Furthermore, the scale-up of LLINs and ACT use in case management has reduced the burden of malaria anaemia in children under five years of age [14] [17]. Long lasting Insecticide Nets have ultimately contributed to the reduction in malaria infections; malaria morbidity and mortality in children under five years of age [18] [19] [20] [21].…”

Section: Advances In Infectious Diseasesmentioning

confidence: 99%

See 2 more Smart Citations

The Impact of Malaria Control Interventions on Malaria and Anaemia in Children under Five after Ten Years of Implementation in the Hohoe Municipality of Ghana

Kweku¹,

Appiah²,

Enuameh³

et al. 2017

AID

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 54%

Section: Advances In Infectious Diseasesmentioning

confidence: 99%

Section: Advances In Infectious Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

The Impact of Malaria Control Interventions on Malaria and Anaemia in Children under Five after Ten Years of Implementation in the Hohoe Municipality of Ghana

Kweku¹,

Appiah²,

Enuameh³

et al. 2017

AID

View full text Add to dashboard Cite

show abstract

“…Great reductions in the number of malaria cases were nevertheless achieved. More recently, programs providing antimalarial drugs and insecticide-treated bed nets have produced appreciable reductions in malaria and malaria-associated deaths in other African countries, including Zambia, Rwanda, Tanzania, Kenya, The Gambia, and South Africa (18)(19)(20)(21)(22).…”

Section: Figurementioning

confidence: 99%

The impact of malaria parasitism: from corpuscles to communities

Wellems¹,

Hayton²,

Fairhurst³

2009

J. Clin. Invest.

View full text Add to dashboard Cite

Malaria continues to exert a tremendous health burden on human populations, reflecting astonishingly successful adaptations of the causative Plasmodium parasites. We discuss here how this burden has driven the natural selection of numerous polymorphisms in the genes encoding hemoglobin and other erythrocyte proteins and some effectors of immunity. Plasmodium falciparum, the most deadly parasite species in humans, displays a vigorous system of antigen variation to counter host defenses and families of functionally redundant ligands to invade human cells. Advances in genetics and genomics are providing fresh insights into the nature of these evolutionary adaptations, processes of parasite transmission and infection, and the difficult challenges of malaria control. Evolutionary origin and host preferences of malariacausing parasitesMost cases of malaria in the world are caused by one of the four species of Plasmodium parasites that predominantly infect humans: Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae. Despite efforts over the past century, the global health burden from Plasmodium infections remains approximately 250-600 million episodes of malaria each year in Africa, Asia, Oceania, and Latin America (1, 2). Of these episodes, approximately 40% are caused by P. falciparum, as are nearly all fatalities attributed to malaria.

show abstract

“…Mothers [14, 15] and other community health workers (CHWs) have demonstrated their ability to treat uncomplicated malaria [16, 17], and community-directed treatment programs have been used successfully for treatment access [18]. Traditional birth attendants have been taught to manage pneumonia and neonatal sepsis [19–21], and these and other traditional practitioners are often the first recourse for management of severe disease [22–25].…”

mentioning

confidence: 99%

Pre-referral Rectal Artesunate Treatment by Community-Based Treatment Providers in Ghana, Guinea-Bissau, Tanzania, and Uganda (Study 18): A Cluster-Randomized Trial

Warsame¹,

Gyapong²,

Mpeka³

et al. 2016

Clin Infect Dis.

View full text Add to dashboard Cite

Background. If malaria patients who cannot be treated orally are several hours from facilities for injections, rectal artesunate prior to hospital referral can prevent death and disability. The goal is to reduce death from malaria by having rectal artesunate treatment available and used. How best to do this remains unknown.Methods. Villages remote from a health facility were randomized to different community-based treatment providers trained to provide rectal artesunate in Ghana, Guinea-Bissau, Tanzania, and Uganda. Prereferral rectal artesunate treatment was provided in 272 villages: 109 through community-based health workers (CHWs), 112 via trained mothers (MUMs), 25 via trained traditional healers (THs), and 26 through trained community-chosen personnel (COMs); episodes eligible for rectal artesunate were established through regular household surveys of febrile illnesses recording symptoms eligible for prereferral treatment. Differences in treatment coverage with rectal artesunate in children aged <5 years in MUM vs CHW (standard-of-care) villages were assessed using the odds ratio (OR); the predictive probability of treatment was derived from a logistic regression analysis, adjusting for heterogeneity between clusters (villages) using random effects.Results. Over 19 months, 54 013 children had 102 504 febrile episodes, of which 32% (31 817 episodes) had symptoms eligible for prereferral therapy; 14% (4460) children received treatment. Episodes with altered consciousness, coma, or convulsions constituted 36.6% of all episodes in treated children. The overall OR of treatment between MUM vs CHW villages, adjusting for country, was 1.84 (95% confidence interval [CI], 1.20–2.83; P = .005). Adjusting for heterogeneity, this translated into a 1.67 higher average probability of a child being treated in MUM vs CHW villages. Referral compliance was 81% and significantly higher with CHWs vs MUMs: 87% vs 82% (risk ratio [RR], 1.1 [95% CI, 1.0–1.1]; P < .0001). There were more deaths in the TH cluster than elsewhere (RR, 2.7 [95% CI, 1.4–5.6]; P = .0040).Conclusions. Prereferral episodes were almost one-third of all febrile episodes. More than one-third of patients treated had convulsions, altered consciousness, or coma. Mothers were effective in treating patients, and achieved higher coverage than other providers. Treatment access was low.Clinical Trials Registration. ISRCTN58046240.

show abstract

Reduced paediatric hospitalizations for malaria and febrile illness patterns following implementation of community-based malaria control programme in rural Rwanda

Cited by 34 publications

References 26 publications

The Impact of Malaria Control Interventions on Malaria and Anaemia in Children under Five after Ten Years of Implementation in the Hohoe Municipality of Ghana

The Impact of Malaria Control Interventions on Malaria and Anaemia in Children under Five after Ten Years of Implementation in the Hohoe Municipality of Ghana

The impact of malaria parasitism: from corpuscles to communities

Pre-referral Rectal Artesunate Treatment by Community-Based Treatment Providers in Ghana, Guinea-Bissau, Tanzania, and Uganda (Study 18): A Cluster-Randomized Trial

Contact Info

Product

Resources

About