Reduced numbers of Langerhans cells and increased HLA‐DR expression in keratinocytes in the oral gingival epithelium of HIV‐infected patients with periodontitis

Myint, Maung Maung; Yuan, Zuan-Ning; Schenck, Karl

doi:10.1034/j.1600-051x.2000.027007513.x

Cited by 23 publications

(28 citation statements)

References 32 publications

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“…In the gingivitis samples, no statistically significant difference was observed between HIV+ and HIV− subjects. These results are not in accordance with a previous study 9 that reported a decrease of LC in AIDS (HIV+) subjects. However, all HIV+ individuals in the present study were using HAART, with a low viral load, and, consequently, showed less direct aggression by LC.…”

Section: Discussioncontrasting

confidence: 99%

“…6 HIV infection is a modifier factor for periodontal disease, responsible for the depletion of CD4+ T lymphocytes, macrophages and LC. 7,8 As a result of this infection, in HIV+ patients with periodontitis, LC were decreased as compared with HIV− subjects 9 ; moreover, the former showed a significant decrease in major histocompatibility complex class II (MHC-II) expression. 10 Recent reports have not indicated a major severity of periodontal disease in HIV+ patients under treatment with antiretroviral agents.…”

Section: Introductionmentioning

confidence: 99%

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Langerhans cells in periodontal disease of HIV- and HIV+ patients undergoing highly active antiretroviral therapy

et al. 2011

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The aim of this study was to assess and compare quantitatively the presence of S100+ Langerhans cells (LC) by immunochemistry techniques in HIV+ and HIV- gingivitis and periodontitis subjects. Additionally, it aimed to evaluate the correlation among densities of these cells with CD4+ and CD8+ T cells, and viral load levels in HIV+ subjects, all using Highly Active Antiretroviral Therapy (HAART). The samples were allocated into four groups: 1) 15 subjects with moderate chronic periodontitis (MCP), HIV+; 2) 15 subjects with MCP, HIV-; 3) 10 subjects with gingivitis (G), HIV+; and 4) 10 subjects with G, HIV-. The S100+ cells were assessed in the pocket epithelium, gingival epithelium, and lamina propria. A statistically significant increase of total S100+ cells in HIV+ periodontitis subjects was observed in relation to HIV- periodontitis subjects. No increase of S100+ cells with increased inflammation was observed. No statistically significant correlation among S100+ cells and blood levels of CD4, CD8, and viral load was observed. In conclusion, the use of HAART can aid in achieving viral loads, and it is suggested that it may prevent the destruction of the LC

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Langerhans cells in periodontal disease of HIV- and HIV+ patients undergoing highly active antiretroviral therapy

et al. 2011

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“…Langerhans cells, which are important for antigen presentation, have been shown to be depleted in the oral mucosa of HIV-infected persons [26,27]. We hypothesize that restoration of Langerhans cells and CD4 T lymphocytes in the oral mucosa occurring in response to reductions in virus load may allow for a marked improvement of HPV antigen recognition and presentation.…”

Section: Discussionmentioning

confidence: 93%

Human Papillomavirus-Associated Oral Warts among Human Immunodeficiency Virus-Seropositive Patients in the Era of Highly Active Antiretroviral Therapy: An Emerging Infection

King

Reznik

O’Daniels

et al. 2002

Clinical Infectious Diseases

131

102

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Oral warts are a manifestation of human papillomavirus infection that have been noted infrequently in persons with human immunodeficiency virus (HIV). A nested case-control study was conducted to assess rates of and risk factors for oral warts among a cohort of HIV-seropositive patients. From 1997 through 1999, 56 patients with oral warts were identified among 2194 HIV-positive patients attending an urban oral health center (prevalence, 2.6%). Incident cases of oral warts were significantly more likely to have been diagnosed in 1999 than they were in 1997-1998 (P=.001). Multivariate analysis indicated that the risk of oral warts was associated with a >/=1-log(10) decrease in HIV RNA level in the 6 months before diagnosis of oral warts (odds ratio [OR], 2.35; 95% confidence interval [CI], 1.08-5.11) and with serologic evidence of chronic or previous infection with hepatitis B virus (OR, 2.66; 95% CI, 1.31-5.41). The incidence of oral warts in HIV-seropositive patients appears to be increasing in the era of highly active antiretroviral therapy. Oral warts were associated with reductions in virus load, which suggests that this may in part be related to immune reconstitution.

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“…The hyperplastic epithelium expresses human leukocyte antigen-DR (HLA-DR) and interleukin (IL)-8 molecules. [1617] The stimulated keratinocytes with HLA-DR molecules in turn release cytokines that increase the T cell trafficking. IL-8 molecules on the other hand bring about HLA-DR + neutrophil exocytosis into parakeratin layer.…”

Section: Etiopathogenesismentioning

confidence: 99%

Verruciform xanthoma: A view on the concepts of its etiopathogenesis

Hegde

Doddawad

Sreeshyla

et al. 2013

J Oral Maxillofac Pathol

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Verruciform xanthoma is a very uncommon papillary growth seen chiefly in the oral mucosa. The presence of foam cells in the connective tissue papillae between the epithelial rete ridges forms the hallmark in its diagnosis. There has been wide speculation and various hypotheses put forth in explaining the etiopathogenesis of verruciform xanthoma and the origin of foam cells. This article aims to update the different hypotheses in understanding the pathogenesis of the lesion.

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Reduced numbers of Langerhans cells and increased HLA‐DR expression in keratinocytes in the oral gingival epithelium of HIV‐infected patients with periodontitis

Abstract: The findings suggest that the oral gingiva in HIV+ patients may be affected by inflammation.

Cited by 23 publications

References 32 publications

Langerhans cells in periodontal disease of HIV- and HIV+ patients undergoing highly active antiretroviral therapy

Langerhans cells in periodontal disease of HIV- and HIV+ patients undergoing highly active antiretroviral therapy

Human Papillomavirus-Associated Oral Warts among Human Immunodeficiency Virus-Seropositive Patients in the Era of Highly Active Antiretroviral Therapy: An Emerging Infection

Verruciform xanthoma: A view on the concepts of its etiopathogenesis

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