Reduced newborn mononuclear cell production of interleukin-10 (IL-10) is associated with wheezing during RSV infections

Brooks, G. Daniel; Meyer, Patricia A; Anklam, Kelly; Roberg, K.A.; Adler, Kiva J.; Gilbertson‐White, Stephanie; Carlson-Dakes, K.; DaSilva, D.F.; Ellerman-Sund, Sarah A; Bhattacharya, Abhik

doi:10.1016/s0091-6749(02)82202-3

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“…We further plan to evaluate these variables over time (developmental aspect), and to determine the relative contribution of these factors in influencing the development of various wheezing phenotypes during early childhood. In the past 2.5 years, we have made considerable progress in evaluating this hypothesis (58–68). However, because the development of the persistent wheezing phenotype cannot be ascertained until children enrolled in the COAST project reach at least 3 years of age, the major outcome measure cannot be evaluated prior to November 2001.…”

Section: The Coast (Childhood Origins Of Asthma) Studymentioning

confidence: 99%

The Childhood Origins of Asthma (COAST) study

Lemanske

2002

Pediatric Allergy Immunology

205

190

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Although asthma is probably a heterogeneous disease or syndrome, three factors and/or events consistently emerge for their ability to significantly influence asthma inception in the first decade of life: immune response aberrations, which appear to be defined best by the concept of cytokine dysregulation; lower respiratory tract infections, in particular respiratory syncytial virus (RSV); and some form of gene-environment interaction that needs to occur at a critical time-period in the development of the immune system or the lung. It remains to be firmly established, however, how any one or all of these factors, either independently or interactively, influence the development of childhood asthma. For example, cytokine dysregulation (T helper 1/T helper 2 imbalance) appears to track best epidemiologically with allergic diseases. As not everyone who undergoes allergic sensitization develops asthma, some other host-environment interaction must need to occur to target this chronic allergic inflammatory response to the lower airway. Some evidence suggests that this event might be an environmental insult in the form of a virus infection, particularly with RSV, which has a predilection for infecting, destroying, and/or in some way biologically altering lower airway epithelium. However, only a fraction of children develop recurrent wheezing following RSV infections, despite the fact that nearly all children have been infected at least once by 2 years of age. Thus, although RSV infections may have the potential of targeting the inflammatory response to the lower airway, they may only be able to do so during a vulnerable time-period during development of the immune system or lung. This developmental component may further reflect important gene-environment interactions that regulate both short- and long-term airway physiological alterations that manifest themselves clinically as childhood asthma. Efforts to determine and define the importance of these three factors to asthma pathogenesis are the focus and goal of the COAST (Childhood Origins of Asthma) project.

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Section: The Coast (Childhood Origins Of Asthma) Studymentioning

confidence: 99%