Reduced Neural Error Signaling in Left Inferior Prefrontal Cortex in Young Adults With ADHD

Vasić, Nenad; Plichta, Michael M.; Fallgatter, Andreas J.; Sosic-Vasic, Zrinka; Grön, Georg

doi:10.1177/1087054712446172

Cited by 22 publications

(21 citation statements)

References 86 publications

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“…Figure 1 shows the PRISMA flow chart (44) of the selected studies. Including the 16 previously included datasets (10–12;45–57) from (6), we retained a total of 26 datasets (10–13;35–43;45–57) for qualitative synthesis and 24 datasets (10–13;35–38;40;41;43;45–57) for meta-analysis [two studies (39;42) did not report coordinates that could be entered into meta-analyses]. The Supplement lists the studies from the updated search that were not included in the meta-analysis, with reasons for their non-inclusion.…”

Section: Resultsmentioning

confidence: 99%

“…As the meta-analysis of ADHD-related hyperactivated regions would have been underpowered (24), we did not run it. Excluding two studies (39;42) reporting no significant contrasts between adults with ADHD and controls, we found a total of 12 papers including tasks exploring inhibition (10–13;35;40;41;45;47;48;50;52) (reporting, overall, 10 contrasts “Controls > ADHD” and 6 contrasts “ADHD > Controls”), six including working memory tasks (37;46;51;54;56;57), six focusing on attention tests (40;41;47–50), five assessing reward processes (35;36;42;43;49;53), one using the instructed fear test (38) and one based on the paced/unpaced finger tapping test (55). Therefore, we did not perform planned sub-group analyses based on task type because the number of contrasts was substantially less than 15 (24).…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, we did not perform planned sub-group analyses based on task type because the number of contrasts was substantially less than 15 (24). Studies with comorbidity-free participants (n=18) (10–13;35–37;39;41;45;46;50;52–57) reported 14 contrasts “Controls > ADHD” and 8 contrasts “ADHD > Controls”. We pooled only the contrasts “Controls > ADHD” from these studies, highlighting the preliminary nature of this analysis, since the number of studies fell just below our threshold.…”

Section: Resultsmentioning

confidence: 99%

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Functional Decoding and Meta-analytic Connectivity Modeling in Adult Attention-Deficit/Hyperactivity Disorder

Cortese

Eickhoff

D’Acunto

et al. 2016

Biological Psychiatry

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Background Task-based fMRI studies of adult Attention-Deficit/Hyperactivity Disorder (ADHD) have revealed various ADHD-related dysfunctional brain regions, with heterogeneous findings across studies. Here, we used novel meta-analytic data-driven approaches to characterize the function and connectivity profile of ADHD-related dysfunctional regions consistently detected across studies. Methods We first conducted an activation likelihood estimation (ALE) meta-analysis of 24 task-based fMRI studies in adults with ADHD. Each ADHD-related dysfunctional region resulting from the ALE meta-analysis was then analyzed using functional decoding based on ~7,500 fMRI experiments in the BrainMap database. This approach allows mapping brain regions to functions not necessarily tested in individual studies, thus suggesting possible novel functions for those regions. Additionally, ADHD-related dysfunctional regions were clustered based on their functional co-activation profiles across all the experiments stored in BrainMap (meta-analytic connectivity modeling). Results ADHD-related hypoactivation was found in left putamen, left inferior frontal gyrus (pars opercularis), left temporal pole, and right caudate. Functional decoding mapped the left putamen and the left temporal lobe to cognitive aspects of music perception/reproduction and language semantics, respectively; both these regions clustered together based on their meta-analytic functional connectivity. Left inferior gyrus mapped to executive function tasks; right caudate mapped both to executive functions tasks and music-related processes. Conclusions Our study provides meta-analytic support to the hypothesis that, in addition to well-known deficits in typical executive functions, impairment in processes related to music perception/reproduction and language semantics may be involved in the pathophysiology of adult ADHD.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Functional Decoding and Meta-analytic Connectivity Modeling in Adult Attention-Deficit/Hyperactivity Disorder

Cortese

Eickhoff

D’Acunto

et al. 2016

Biological Psychiatry

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“…The inferior frontal gyrus is regarded as the inhibitory component of the prefrontal-limbic system (Cha et al, 2016). Studies suggest that the IFG is involved in the regulation of emotion and attention by inhibiting the negative feedback loop and interpreting emotional states (Cha et al, 2016, Vasic et al, 2014). …”

Section: Discussionmentioning

confidence: 99%

Anatomical brain difference of subthreshold depression in young and middle-aged individuals

Wang

Hwang

et al. 2017

NeuroImage: Clinical

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BackgroundSubthreshold depression (StD) is associated with substantial functional impairments due to depressive symptoms that do not fully meet the diagnosis of major depressive disorder (MDD). Its high incidence in the general population and debilitating symptoms has recently put it at the forefront of mood disorder research.AimIn this study we investigated common volumetric brain changes in both young and middle-aged StD patients.MethodsTwo cohorts of StD patients, young and middle-aged, (n = 57) and matched controls (n = 76) underwent voxel-based morphometry (VBM).ResultsVBM analysis found that: 1) compared with healthy controls, StD patients showed decreased gray matter volume (GMV) in the bilateral globus pallidus and precentral gyrus, as well as increased GMV in the left thalamus and right rostral anterior cingulate cortex/medial prefrontal cortex; 2) there is a significant association between Center for Epidemiological Studies Depression Scale scores and the bilateral globus pallidus (negative) and left thalamus (positive); 3) there is no interaction between age (young vs. middle-age) and group (StD vs. controls).ConclusionsOur findings indicate significant VBM brain changes in both young and middle-aged individuals with StD. Individuals with StD, regardless of age, may share common neural characteristics.

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“…The complicated pathophysiology of ADHD has been widely investigated through task and resting-state functional magnetic resonance imaging (fMRI) studies. Task-state fMRI studies commonly employed various task paradigms, e.g., Go/No Go (Schulz et al, 2004; Newman et al, 2015), Eriksen Flanker Task (Vaidya et al, 2005; Vasic et al, 2014). These tasks are complicated, and various paradigms did not exhibit consistent results (Cortese et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Inconsistency in Abnormal Brain Activity across Cohorts of ADHD-200 in Children with Attention Deficit Hyperactivity Disorder

et al. 2017

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Many papers have shown results from the multi-site dataset of resting-state fMRI (rs-fMRI) in attention deficit hyperactivity disorder (ADHD), a data-sharing project named ADHD-200. However, few studies have illustrated that to what extent the pooled findings were consistent across cohorts. The present study analyzed three voxel-wise whole-brain metrics, i.e., amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), and degree centrality (DC) based on the pooled dataset as well as individual cohort of ADHD-200. In addition to the conventional frequency band of 0.01–0.08 Hz, sub-frequency bands of 0–0.01, 0.01–0.027, 0.027–0.073, 0.073–0.198, and 0.198–0.25 Hz, were assessed. While the pooled dataset showed abnormal activity in some brain regions, e.g., the bilateral sensorimotor cortices, bilateral cerebellum, and the bilateral lingual gyrus, these results were highly inconsistent across cohorts, even across the three cohorts from the same research center. The standardized effect size was rather small. These findings suggested a high heterogeneity of spontaneous brain activity in ADHD. Future studies based on multi-site large-sample dataset should be performed on pooled data and single cohort data, respectively and the effect size must be shown.

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Reduced Neural Error Signaling in Left Inferior Prefrontal Cortex in Young Adults With ADHD

Cited by 22 publications

References 86 publications

Functional Decoding and Meta-analytic Connectivity Modeling in Adult Attention-Deficit/Hyperactivity Disorder

Functional Decoding and Meta-analytic Connectivity Modeling in Adult Attention-Deficit/Hyperactivity Disorder

Anatomical brain difference of subthreshold depression in young and middle-aged individuals

Inconsistency in Abnormal Brain Activity across Cohorts of ADHD-200 in Children with Attention Deficit Hyperactivity Disorder

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