Reduced multimodal integration of memory features following continuous theta burst stimulation of angular gyrus

Yazar, Yasemin; Bergström, Zara M.; Simons, Jon S.

doi:10.1016/j.brs.2017.02.011

Cited by 67 publications

(65 citation statements)

References 40 publications

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“…Thus, different task demands would involve distinct process-specific alliances (that is, transient interactions between several brain regions, Cabeza & Moscovitch, 2013;Moscovitch et al, 2016). Notably, in accord with this view, even though some aspects of our results seem to be inconsistent with previous studies that used different tasks (Bonnici et al, 2016;Yazar et al, 2017), our findings do converge across the three studies that used the same paradigm (i.e., the current study, Ben-Zvi et al, 2015, andLevy, 2014), where task demands were kept similar.…”

Section: Discussionsupporting

confidence: 77%

“…They provide a straightforward answer to the puzzle arising from our previous findings (in Ben-Zvi et al, 2015versus Tibon & Levy, 2014, by suggesting that the AnG is involved in (at least) two memory-related processes: multimodal integration at encoding, and construction of representations that enable vivid recall, either during encoding or during retrieval. Based on current and prior evidence (Bonnici et al, 2016;Yazar et al, 2017), it is plausible that the extent of AnG activation in mnemonic processes is determined by specific cognitive demands posed by the task (e.g., Moscovitch et al, 2016). Future studies might systematically manipulate such demands within the same experimental paradigm, and examine activation during encoding and retrieval, possibly using a more fine-grained vividness rating (see also Richter et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…In particular, two previous studies have shown retrieval-related involvement of the AnG in tasks that require multimodal reinstatement. In the first study, Yazar et al (2017) used continuous post-encoding theta burst transcranial magnetic stimulation to interrupt AnG functioning. Participants encoded objects which were presented both visually and auditorily, and were subsequently asked to retrieve unimodal sources (e.g., which side + which location) or crossmodal sources (e.g., which side + male or female voice) of the studied objects.…”

Section: Discussionmentioning

confidence: 99%

“…CoBRA critically predicts that tasks that demand the reinstatement of intermodal features, such as voices with faces, will depend more on the vPPC than tasks that depend on within-modality associations. This account has received support from several studies (Bonnici et al, 2016;Yazar et al, 2017), but other examinations of CoBRA were inconclusive, with multimodal integration deficits found in parietal lesion patients (Ben-Zvi et al, 2015), but no multimodal vs. unimodal associative memory effects on parietal scalp ERPs recorded in healthy volunteers (Tibon & Levy, 2014).…”

Section: Introductionmentioning

confidence: 87%

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Multimodal integration and vividness in the angular gyrus during episodic encoding and retrieval

Tibon

Fuhrmann

Levy

et al. 2018

Preprint

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Much evidence suggests that the angular gyrus (AnG) is involved in episodic memory, but its precise role is yet to be determined. We examined two possible accounts, within the same experimental paradigm: the CoBRA account (Shimamura, 2011), which suggests that the AnG acts as a convergence zone that binds multimodal episodic features; and the Subjectivity account (Yazar et al., 2012), which implicates AnG involvement in subjective mnemonic experience (such as vividness or confidence). fMRI was employed during both encoding and retrieval of paired-associates. During study, female and male human participants memorised picture-pairs of common objects (in the unimodal task) or of an object-picture and an environmental sound (in the crossmodal task). At test, they performed a cuedrecall task, and further indicated the vividness of their memory. During retrieval, BOLD activation in the AnG was greatest for vividly remembered associates, consistent with the Subjectivity account.During encoding, the same effect of vividness was found, but this was further modulated by task:Greater activations were associated with subsequent recall in the crossmodal than the unimodal task.Thus, encoding data suggests an additional role to the AnG in cross-modal integration, consistent with its role at retrieval proposed by CoBRA. These results resolve some of the puzzles in the literature and indicate that the AnG can play different roles during encoding and retrieval, determined by the cognitive demands posed by different mnemonic tasks. ANGULAR GYRUS IN EPISODIC MEMORY 2 Significance StatementWe offer new insights into the multiplicity of processes that are associated with angular gyrus (AnG) activation during encoding and retrieval of newly formed memories. We used fMRI while human participants learned and subsequently recalled pairs of objects presented to the same sensory modality or to different modalities. We were able to show that the AnG is involved when vivid memories are created and retrieved, as well as when encoded information is integrated across different sensory modalities. These findings provide novel evidence for the contribution of the AnG to our subjective experience of remembering, alongside its role in integrative processes that promote subsequent memory. ANGULAR GYRUS IN EPISODIC MEMORY

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 87%

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Multimodal integration and vividness in the angular gyrus during episodic encoding and retrieval

Tibon

Fuhrmann

Levy

et al. 2018

Preprint

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“…Activity in the AG tracks how precisely a representation in memory matches the original properties of the encoded stimulus (Richter, Cooper, Bays, & Simons, 2016), such that physical stimulus properties can be decoded from memory-related activity (Kuhl & Chun, 2014;Lee & Kuhl, 2016;St-Laurent, Abdi, & Buchsbaum, 2015). Access to these precise representations can be temporarily modulated using non-invasive stimulation targeting the AG, further supporting its direct involvement in recollection (Bonnici, Cheke, Green, FitzGerald & Simons, 2018;Nilakantan, Bridge, Gagnon, Vanhaerents, & Voss, 2017;Thakral, Madore, & Schacter, 2017;Wang et al, 2014;Yazar, Bergström, & Simons, 2017).…”

Section: Introductionmentioning

confidence: 96%

Recollection and prior knowledge recruit the left angular gyrus during recognition

Bellana¹,

Ladyka‐Wojcik

Lahan

et al. 2019

Preprint

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The human angular gyrus (AG) is implicated in recollection, or our ability to retrieve detailed memory content from a specific study episode. Parallel work also highlights a key role of the AG in the representation of general knowledge and semantics. How these two lines of research converge remains unclear. The present fMRI experiment used a remember-know paradigm with famous and non-famous faces to test whether activity in the AG could be modulated by both task-specific recollection and general prior knowledge in the same participants. Increased BOLD activity in the left AG was observed during both recollection in the absence of prior knowledge (i.e., recollected > non-recollected or correctly rejected non-famous faces) and when prior knowledge was accessed in the absence of recollection (i.e., famous > non-famous correct rejections). This pattern was unique to the left AG, and was not present in any other regions of the lateral inferior parietal lobe. Furthermore, the response profile of the left AG was consistent with accounts of recollection strength. Recollection-related activity was greater for faces with longer exposures at encoding than those with shorter exposures and was greater for stimuli with prior knowledge than those without, despite prior knowledge being incidental to the recognition decision. Therefore, the left AG is recruited during the access of both task-specific recollection and general prior knowledge, with greater activity as the amount of retrieved information increases, irrespective of its episodic or semantic nature. Significance StatementThe human angular gyrus (AG) is often implicated in our ability to remember past events. A separate line of research examining our ability to represent general knowledge has also highlighted the AG as a core region of interest. To reconcile these separate views of AG function, we used fMRI to test whether the human left AG was sensitive to remembering details from a specific study episode (i.e., recollection) or more general prior knowledge, within the same participants. Overall, activity in the left AG was sensitive to both recollection and prior knowledge, suggesting any complete functional account of the left AG during retrieval must consider its sensitivity to both kinds of mnemonic representations.

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Differences in executive abilities rather than associative processes contribute to memory development

Müller

Kohn

Buuren

et al. 2021

Human Brain Mapping

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Children's learning capabilities change while growing up. One framework that describes the cognitive and neural development of children's growing learning abilities is the two-component model. It distinguishes processes that integrate separate features into a coherent memory representation (associative component) and executive abilities, such as elaboration, evaluation, and monitoring, that support memory processing (strategic component). In an fMRI study using an object-location association paradigm, we investigated how the two components influence memory performance across development. We tested children (10-12 years, n = 31), late adolescents (18 years, n = 29), and adults (25+ years, n = 30). For studying the associative component, we also probed how the utilisation of prior knowledge (schemas) facilitates memory across age groups. Children had overall lower retrieval performance, while adolescents and adults did not differ from each other. All groups benefitted from schemas, but this effect did not differ between groups. Performance differences between groups were associated with deactivation of the dorsal medial prefrontal cortex (dmPFC), which in turn was linked to executive functioning. These patterns were stronger in adolescents and adults and seemed absent in children.Thus, the children's executive system, the strategic component, is not as mature and thus cannot facilitate memory performance in the same way as in adolescents/adults.In contrast, we did not find age-related differences in the associative component; with activity in the angular gyrus predicting memory performance systematically across groups. Overall, our results suggest that differences of executive rather than associative abilities explain memory differences between children, adolescents, and adults.

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Reduced multimodal integration of memory features following continuous theta burst stimulation of angular gyrus

Cited by 67 publications

References 40 publications

Multimodal integration and vividness in the angular gyrus during episodic encoding and retrieval

Multimodal integration and vividness in the angular gyrus during episodic encoding and retrieval

Recollection and prior knowledge recruit the left angular gyrus during recognition

Differences in executive abilities rather than associative processes contribute to memory development

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