Reduced mortality in murine cytomegalovirus infected mice following prophylactic murine interferon-γ treatment

Fennie, Elizabeth H.; Lie, Yolanda; Low, Mari-Anne L.; Gribling, Peter; Anderson, Kevin

doi:10.1016/0166-3542(88)90012-5

Cited by 20 publications

(18 citation statements)

References 39 publications

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“…A number of studies have found that IFN-g plays a protective role during acute MCMV infection in vivo. IFN-g given before infection decreases virus-induced mortality after virus challenge [49].…”

Section: Discussionmentioning

confidence: 99%

Characterization of Virus‐Induced Interferon‐γ Responses in Mice Previously Infected with Murine Cytomegalovirus

2001

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These studies demonstrate that in vitro stimulation of spleen cells from murine cytomegalovirus (MCMV) immune mice with MCMV-infected fibroblasts induces production of interferon (IFN)-gamma. This response is specific to MCMV, is not generalized to heterologous viruses, and also is not H-2 restricted. Both early and late CMV antigens induce IFN-gamma. In in vitro cell depletion and direct cell selection experiments, T lymphocytes were responsible for IFN-gamma production. Although both CD4 and CD8 cells appear to be required to induce the response, the cell subset that releases the IFN-gamma is not yet undefined. In vivo, this IFN-gamma response appears early after acute infection and persists > or =1 year. The response is not seen in T cell-deficient mice. Thus, previous MCMV infection results in a virus-specific IFN-gamma response in spleen cells exposed to MCMV antigens. The pathophysiologic significance of these observations is now under study.

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Section: Discussionmentioning

confidence: 99%

Characterization of Virus‐Induced Interferon‐γ Responses in Mice Previously Infected with Murine Cytomegalovirus

2001

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“…In contrast, IFN-Á has been shown to restore CMV antigen presentation, which implies a role for IFN-Á in the T-cell-mediated control of CMV infection [70][71][72]. Prophylactic IFN-Á treatment has been shown to reduce mortality in CMV-infected mice [73], and IFN-Á-depleted mice demonstrate increased murine CMV titers in multiple organs [74]. Furthermore, IFN-Á has been shown to be important for the clearance of murine CMV (MCMV) in infected animals [75,76], and experiments performed in mice lacking the IFN-Á receptor demonstrate that IFN-Á reversibly inhibited reactivation of latent MCMV [77].…”

Section: The Importance Of Immune Activation In the Reactivation Of Hcmvmentioning

confidence: 99%

Human Cytomegalovirus Latency and Reactivation – A Delicate Balance between the Virus and Its Host’s Immune System

Söderberg‐Nauclér

Nelson

1999

Intervirology

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Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that still causes severe morbidity and mortality in immunocompromised individuals. During its evolution, the virus has developed sophisticated methods to evade immune recognition and to establish life-long persistence in its host. Today, we know that the virus establishes latency in myeloid lineage cells and that the virus is dependent on immune activation mechanisms to reactivate it from latency to produce a new viral progeny. During this process, a number of viral proteins are produced that interfere with different immune recognition pathways. The current knowledge of the delicate balance between the virus‘ continuous existence and its host’s immune system will be summarized in this chapter.

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“…Additionally, secretion of IFN-␥ by NK cells is important during the acute phase of MCMV infection (24,35,54,61). IFN-␥ inhibits MCMV replication in vitro (23,29,42,47) and protects against MCMV-induced lethality and pathogenesis in vivo (20,24,41). IFN-␥ is also critical for efficient clearance of persistent viral replication (30, 41) and suppresses MCMV reactivation from latency (39, 41).…”

mentioning

confidence: 99%

Natural Killer Cells Utilize both Perforin and Gamma Interferon To Regulate Murine Cytomegalovirus Infection in the Spleen and Liver

Loh¹,

Chu

O’Guin³

et al. 2005

J Virol

151

139

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Reduced mortality in murine cytomegalovirus infected mice following prophylactic murine interferon-γ treatment

Cited by 20 publications

References 39 publications

Characterization of Virus‐Induced Interferon‐γ Responses in Mice Previously Infected with Murine Cytomegalovirus

Characterization of Virus‐Induced Interferon‐γ Responses in Mice Previously Infected with Murine Cytomegalovirus

Human Cytomegalovirus Latency and Reactivation – A Delicate Balance between the Virus and Its Host’s Immune System

Natural Killer Cells Utilize both Perforin and Gamma Interferon To Regulate Murine Cytomegalovirus Infection in the Spleen and Liver

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