Reduced mind-wandering in mild cognitive impairment: Testing the spontaneous retrieval deficit hypothesis.

Niedźwieńska, Agnieszka; Kvavilashvili, Lia

doi:10.1037/neu0000457

Cited by 20 publications

(36 citation statements)

References 94 publications

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“…A recent study reported reduced mind wandering in mild Alzheimer's disease during concurrent performance of a sustained attention task (24). Reduced spontaneous mind wandering was also recently demonstrated in mild cognitive impairment during a simple vigilance task (25). In this paper, we empirically investigate how alterations in structural and functional brain network integrity across dementia syndromes relate to mind wandering.…”

Section: Significancementioning

confidence: 89%

Hippocampal atrophy and intrinsic brain network dysfunction relate to alterations in mind wandering in neurodegeneration

O’Callaghan

Shine

Hodges

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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Mind wandering represents the human capacity for internally focused thought and relies upon the brain’s default network and its interactions with attentional networks. Studies have characterized mind wandering in healthy people, yet there is limited understanding of how this capacity is affected in clinical populations. This paper used a validated thought-sampling task to probe mind wandering capacity in two neurodegenerative disorders: behavioral variant frontotemporal dementia [(bvFTD); n = 35] and Alzheimer’s disease [(AD); n = 24], compared with older controls (n = 37). These patient groups were selected due to canonical structural and functional changes across sites of the default and frontoparietal networks and well-defined impairments in cognitive processes that support mind wandering. Relative to the controls, bvFTD patients displayed significantly reduced mind wandering capacity, offset by a significant increase in stimulus-bound thought. In contrast, AD patients demonstrated comparable levels of mind wandering to controls, in the context of a relatively subtle shift toward stimulus-/task-related forms of thought. In the patient groups, mind wandering was associated with gray matter integrity in the hippocampus/parahippocampus, striatum, insula, and orbitofrontal cortex. Resting-state functional connectivity revealed associations between mind wandering capacity and connectivity within and between regions of the frontoparietal and default networks with distinct patterns evident in patients vs. controls. These findings support a relationship between altered mind wandering capacity in neurodegenerative disorders and structural and functional integrity of the default and frontoparietal networks. This paper highlights a dimension of cognitive dysfunction not well documented in neurodegenerative disorders and validates current models of mind wandering in a clinical population.

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Section: Significancementioning

confidence: 89%

Hippocampal atrophy and intrinsic brain network dysfunction relate to alterations in mind wandering in neurodegeneration

O’Callaghan

Shine

Hodges

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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“…While O'Callaghan et al (2019) did not find a reliable reduction in spontaneous mind-wandering in patients with Alzheimer's disease, Niedźwieńska and Kvavilashvili (2018) reported marked reduction in spontaneous mind-wandering (especially thoughts about the past) in participants with Mild Cognitive Impairment compared to healthy controls. Niedźwieńska and Kvavilashvili (2018) suggested that the spontaneous processes of eliciting thoughts in response to incidental cues, which is preserved in healthy ageing, may be particularly disrupted at early stages of Alzheimer's disease (see also McDaniel, Shelton, Breneiser, Moynan, & Balota, 2011;Niedźwieńska, Kvavilashvili, Ashaye, & Necar, 2017). Future research needs to examine this idea with a special focus on spontaneous future thinking.…”

Section: Effects Of Individual Differences Age and Neurological Injmentioning

confidence: 92%

Section: Effects Of Individual Differences Age and Neurological Injmentioning

confidence: 99%

“…The potential importance of cues has been also highlighted in two recent studies on pathological ageing and spontaneous mind-wandering using an easy, undemanding version of the vigilance task with cue words (Niedźwieńska & Kvavilashvili, 2018) and the shape expectations task without verbal cues (O'Callaghan et all., 2019) (this task was used by Irish et al, 2019). While O'Callaghan et al (2019) did not find a reliable reduction in spontaneous mind-wandering in patients with Alzheimer's disease, Niedźwieńska and Kvavilashvili (2018) reported marked reduction in spontaneous mind-wandering (especially thoughts about the past) in participants with Mild Cognitive Impairment compared to healthy controls. Niedźwieńska and Kvavilashvili (2018) suggested that the spontaneous processes of eliciting thoughts in response to incidental cues, which is preserved in healthy ageing, may be particularly disrupted at early stages of Alzheimer's disease (see also McDaniel, Shelton, Breneiser, Moynan, & Balota, 2011;Niedźwieńska, Kvavilashvili, Ashaye, & Necar, 2017).…”

Section: Effects Of Individual Differences Age and Neurological Injmentioning

confidence: 99%

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Spontaneous future cognition: the past, present and future of an emerging topic

Cole

Kvavilashvili

2019

Psychological Research

Self Cite

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In this Editorial, we discuss the past, present and future of an emerging and fast-developing field-spontaneous future cognition. In tracking the past of this research, the trajectories of research on mind-wandering, episodic future thinking and prospective memory are briefly examined, and their relation with spontaneous future cognition demarcated. Three broad methodological approaches (questionnaire, naturalistic and laboratory) used to study spontaneous future thoughts are described, providing an overview of the field. The present state of this research is represented by a themed analysis of the articles included in this Special Issue. The breadth of studies (covering cognitive mechanisms, developmental stages and psychopathology) have already led to important insights, especially concerning the conditions in which spontaneous future thoughts most commonly arise and who may be predisposed to experiencing them. In the future, greater effort should focus on developing a theoretical account of spontaneous future cognition-this may increase our understanding of how and why spontaneous future thoughts occur. If future research in this area reflects the diversity and depth within this Special Issue, a flourishing of research on spontaneous future cognition will be on the horizon in years or perhaps decades to come.

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“…Reduced spontaneous mind wandering has been further been demonstrated in mild cognitive impairment during performance of a simple vigilance task (27). No study to date, however, has empirically investigated how alterations in structural and functional brain network integrity across dementia syndromes relate to mind wandering.…”

Section: Significance Statementmentioning

confidence: 99%

Hippocampal atrophy and intrinsic brain network dysfunction relate to alterations in mind wandering in neurodegeneration

O’Callaghan

Shine

Hodges

et al. 2017

Preprint

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Mind wandering represents the human capacity for internally focussed thought, and relies upon the brain’s default network and its interactions with attentional networks. Studies have characterised mind wandering in healthy people, yet there is limited understanding of how this capacity is affected in clinical populations. This study used a validated thought-sampling task to probe mind wandering capacity in two neurodegenerative disorders: behavioural variant frontotemporal dementia (bvFTD; n=35) and Alzheimer’s disease (AD; n=24), compared to older controls (n=37). These patient groups were selected due to canonical structural and functional changes across sites of the default and frontoparietal networks, and well-defined impairments in cognitive processes that support mind wandering. Relative to controls, bvFTD patients displayed significantly reduced mind wandering capacity, offset by a significant increase in stimulus-bound thought. In contrast, AD patients demonstrated comparable levels of mind wandering to controls, in the context of a relatively subtle shift towards stimulus-/task-related forms of thought. In the patient groups, mind wandering was associated with grey matter integrity in the hippocampus/parahippocampus, striatum, insula and orbitofrontal cortex. Resting state functional connectivity revealed associations between mind wandering capacity and connectivity within and between regions of the frontoparietal and default networks, with distinct patterns evident in patients vs. controls. These findings support a relationship between altered mind wandering capacity in neurodegenerative disorders, and structural and functional integrity of the default and frontoparietal networks. This study highlights a dimension of cognitive dysfunction not well documented in neurodegenerative disorders, and validates current models of mind wandering in a clinical population.Significance statementHumans spend much of their waking life engaged in mind wandering. Underlying brain systems supporting this complex ability have been established in healthy individuals, yet it remains unclear how mind wandering is altered in neuropsychiatric populations. We reveal changes in the thought profiles elicited during periods of low cognitive demand in dementia, resulting in reduced mind wandering and an increased propensity towards stimulus-bound thought. These altered thought profiles were associated with structural and functional brain changes in the hippocampus, default and frontoparietal networks; key regions implicated in internal mentation in healthy individuals. Our findings provide a unique clinical validation of current theoretical models of mind wandering, and reveal a dimension of cognitive dysfunction that has received scant attention in dementia.

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Reduced mind-wandering in mild cognitive impairment: Testing the spontaneous retrieval deficit hypothesis.

Cited by 20 publications

References 94 publications

Hippocampal atrophy and intrinsic brain network dysfunction relate to alterations in mind wandering in neurodegeneration

Hippocampal atrophy and intrinsic brain network dysfunction relate to alterations in mind wandering in neurodegeneration

Spontaneous future cognition: the past, present and future of an emerging topic

Hippocampal atrophy and intrinsic brain network dysfunction relate to alterations in mind wandering in neurodegeneration

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