Reduced methicillin-resistant Staphylococcus aureus biofilm formation in bone cavities by photodynamic therapy

Araújo, Thalita Santos Dantas; Rodrigues, Paôlla Layanna Fernandes; Santos, Mariana Sousa; Oliveira, Janeide Muritiba de; Rosa, Luciano Pereira; Bagnato, Vanderlei Salvador; Blanco, Kate Cristina; Silva, Francine Cristina da

doi:10.1016/j.pdpdt.2017.12.011

Cited by 34 publications

(16 citation statements)

References 27 publications

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“…The aPDT can be applied either with broadband halogen lamps or light emitting diodes (LED) as light sources [16][17][18][19]. Nevertheless, the limited emission wavelength spectrum associated with cheap LED devices and broadband halogen lamps results in tissue overheating [1].…”

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confidence: 99%

Inactivation of Oral Biofilms Using Visible Light and Water-Filtered Infrared a Radiation and Indocyanine Green

et al. 2019

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Aim: To investigate the antimicrobial photodynamic therapy (aPDT) of visible light and water-filtered infrared A radiation in combination with indocyanine green (ICG) on planktonic oral microorganisms as well as on oral biofilm. Methods: The irradiation was conducted for 5 min in combination with ICG. Treatment with chlorhexidine served as a positive control. The number of colony forming units and bacterial vitality were quantified. Results: All tested bacterial strains and salivary bacteria were killed at a level of 3log10. The colony forming units of the initial mature oral biofilms were strongly reduced. The high bactericidal effect of aPDT was confirmed by live/dead staining. Conclusion: The aPDT using visible light and water-filtered infrared A radiation and ICG has the potential to treat periodontitis and peri-implantitis.

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confidence: 99%

Inactivation of Oral Biofilms Using Visible Light and Water-Filtered Infrared a Radiation and Indocyanine Green

et al. 2019

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“…Conversely, part of the excited photosensitizer remains unstable and does not carry out any subsequent reactions, but releases its energy as fluorescence or heat [ 18 ]. Common broadband halogen lamps or light-emitting diodes (LED) are suitable as light sources for the purpose of light-induced activation [ 13 , 19 , 20 , 21 ]. Nevertheless, the limited emission wavelength spectrum associated with low-cost LED devices and halogen lamps leads to tissue overheating [ 22 ].…”

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confidence: 99%

Microbial Composition of Oral Biofilms after Visible Light and Water-Filtered Infrared a Radiation (VIS+wIRA) in Combination with Indocyanine Green (ICG) as Photosensitizer

et al. 2020

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In view of increasing antibiotic resistance, antimicrobial photodynamic therapy (aPDT) is an alternative treatment method used to eradicate the microbial community of oral biofilms that can be responsible for different oral infections. In order to investigate changes in the microbial composition after application of aPDT with visible light and water-filtered infrared A (VIS+wIRA) in combination with indocyanine green (ICG), oral microorganisms of the initial and mature biofilm were evaluated by mass spectrometry (MALDI-TOF-MS). To determine surviving microorganisms using MALDI-TOF-MS, an in situ biofilm was irradiated with VIS+wIRA for five minutes in the presence of ICG (300 and 450 µg/mL, respectively). Treatment with chlorhexidine (0.2%) served as positive control. Identified microorganisms of the initial biofilm treated with ICG showed a clear reduction in diversity. The microbial composition of the mature oral biofilm also showed changes after the implementation of aPDT, which mainly resulted in a shift in the percentage of bacterial species. The resulting destruction of the microbial balance within the oral biofilm by aPDT using VIS+wIRA and ICG can be seen as an advantageous supplementary approach in the adjunctive treatment of periodontitis and peri-implantitis.

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“…To date, numerous PS have been synthesized for antimicrobial PDT, both based on the synthetic tetrapyrrole compounds and other dyes (acridine, toluidine, hypericin, etc.) [36][37][38][39][40][41][42]. Ammonium or pyridinium groups are incorporated into such pigments to give them greater antimicrobial activity due to a positive charge on the nitrogen atom.…”

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Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy

Suvorov

Pogorilyy

Diachkova

et al. 2021

IJMS

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The rapid growth of drug-resistant bacteria all over the world has given rise to a major research challenge, namely a search for alternative treatments to which bacteria will be unable to develop resistance. Photodynamic therapy is an approach of this kind. It involves the use of photosensitizers in combination with visible light at a certain wavelength to excite the former and generate reactive oxygen species. Various synthetic heterocyclic compounds are used as photosensitizers. Of these, derivatives of natural chlorophylls have a special place due to their properties. This review deals with the use of such compounds in antimicrobial PDT.

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Reduced methicillin-resistant Staphylococcus aureus biofilm formation in bone cavities by photodynamic therapy

Cited by 34 publications

References 27 publications

Inactivation of Oral Biofilms Using Visible Light and Water-Filtered Infrared a Radiation and Indocyanine Green

Inactivation of Oral Biofilms Using Visible Light and Water-Filtered Infrared a Radiation and Indocyanine Green

Microbial Composition of Oral Biofilms after Visible Light and Water-Filtered Infrared a Radiation (VIS+wIRA) in Combination with Indocyanine Green (ICG) as Photosensitizer

Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy

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