Reduced memory precision in older age is associated with functional and structural differences in the angular gyrus

Korkki, Saana M.; Richter, Franziska R.; Gellersen, Helena M.; Simons, Jon S.

doi:10.1016/j.neurobiolaging.2023.04.009

Cited by 6 publications

(20 citation statements)

References 110 publications

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“…Notably, the GMV effects on the fMRI subsequent memory effect were mostly found in posterior brain regions despite the GMV age differences being most pronounced frontally (Figure 1A). This may be explained by the use of a visual encoding task and is in line with a recent study, in which angular gyrus GMV was found to predict differences in memory precision in older adults (Korkki et al, 2023). An inverse relationship between GMV and SMV was found in the precuneus and medial PFC (Table 1).…”

Section: Discussionsupporting

confidence: 90%

Age-related differences in fMRI subsequent memory effects are directly linked to local grey matter volume differences

Kizilirmak

Soch

Richter

et al. 2023

Preprint

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Episodic memory performance declines with increasing age, and older adults typically show reduced activation of inferior temporo-parietal cortices in functional magnetic resonance imaging (fMRI) studies of episodic memory formation. Given the age-related cortical volume loss, it is likely that age-related reduction of memory-related fMRI activity can partially be attributed to reduced grey matter volume (GMV). We performed a voxel-wise multimodal neuroimaging analysis of fMRI correlates of successful memory encoding, using regional GMV as covariate. In a large cohort of healthy adults (106 young, 111 older), older adults showed reduced GMV across the entire neocortex and reduced encoding-related activation of inferior temporal and parieto-occipital cortices compared to young adults. Importantly, these reduced fMRI activations during successful encoding in older adults could in part be attributed to lower regional GMV. Our results highlight the importance of controlling for structural MRI differences in fMRI studies in older adults but also demonstrate that age-related differences in memory-related fMRI activity cannot be attributed to structural variability alone.

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Section: Discussionsupporting

confidence: 90%

Age-related differences in fMRI subsequent memory effects are directly linked to local grey matter volume differences

Kizilirmak

Soch

Richter

et al. 2023

Preprint

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“…This general pattern of findings was replicated in participants with autism spectrum disorder and neurotypical controls in Cooper et al (2017). However, Korkki et al (2023) reported that fMRI BOLD activity…”

Section: Introductionmentioning

confidence: 70%

“…The copyright holder for this preprint this version posted June 10, 2024. ; https://doi.org/10.1101/2024.06.10.598309 doi: bioRxiv preprint 16 closely adjacent to one of the apriori defined AG ROIs (MNI coordinates: -54, -66, 33, as reported by Korkki et al, 2023). 4) and subjected to a trial type (3) x region (7) ANOVA.…”

Section: Whole Brain Analysesmentioning

confidence: 99%

“…By contrast, the one-way ANOVA model that employed the factor of trial type (location hits, guesses and correct rejections) revealed a significant main effect in multiple regions, including bilateral dorsal parietal cortex (DPC) extending into the precuneus and posterior cingulate, premotor cortex, left dorsal prefrontal cortex, and left and right AG (see Table 1 and Figure 3). The left AG cluster was 16 closely adjacent to one of the apriori defined AG ROIs (MNI coordinates: -54, -66, 33, as reported by Korkki et al, 2023) 4) and subjected to a trial type (3) x region (7) ANOVA. The ANOVA gave rise to a main effect of region (F 2.78, 61.16 = 36.90, p < 0.001, partial η 2 = 0.63), and a trial type x region interaction (F 5.21, 114.64 = 30.64, p < 0.001, partial η 2 = 0.58), indicating that the pattern of effects differed across regions.…”

Section: Whole Brain Analysesmentioning

confidence: 99%

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Neural correlates of retrieval success and precision: an fMRI study

Hou,

Hill,

Aktas

et al. 2024

Preprint

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Prior studies examining the neural mechanisms underlying retrieval success and precision have yielded inconsistent results. Here, their neural correlates were examined using a memory task that assessed precision for spatial location. A sample of healthy young adults underwent fMRI scanning during a single study-test cycle. At study, participants viewed a series of object images, each placed at a randomly selected location on an imaginary circle. At test, studied images were intermixed with new images and presented to the participants. The requirement was to move a cursor to the location of the studied image, guessing if necessary. Participants then signaled whether the presented image as having been studied. Memory precision was quantified as the angle between the studied location and the location selected by the participant. A precision effect was evident in the left angular gyrus, where BOLD activity covaried across trials with location accuracy. Multi-voxel pattern analysis also revealed a significant item-level reinstatement effect for high-precision trials. There was no evidence of a retrieval success effect in the angular gyrus. BOLD activity in the hippocampus was insensitive to both success and precision. These findings are partially consistent with prior evidence that success and precision are dissociable features of memory retrieval.

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“…Echoing the findings of Greene and Naveh-Benjamin, Korkki and colleagues found only small differences in overall memory for the objects, but significant age-related declines in the precision of episodic retrieval. In a further study, Korkki et al [53] measured brain activity in younger and older adults in the retrieval phase of the same task, and found that age-related reductions in hippocampal activity were associated with poorer recall of object features, and that reductions in activity in the angular gyrus were specifically associated with an age-related decline in precision. This result implies that the older adults’ problems with precision lie at the retrieval phase, but a previous study [55] on young adults found that encoding activity in the inferior frontal gyrus and fusiform cortex was associated with both later success and precision of memory retrieval.…”

Section: Age-related Differences In Generality and Specificitymentioning

confidence: 99%

Memory, aging and the brain: Old findings and current issues

Craik

2023

Aging Brain

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Reduced memory precision in older age is associated with functional and structural differences in the angular gyrus

Cited by 6 publications

References 110 publications

Age-related differences in fMRI subsequent memory effects are directly linked to local grey matter volume differences

Age-related differences in fMRI subsequent memory effects are directly linked to local grey matter volume differences

Neural correlates of retrieval success and precision: an fMRI study

Memory, aging and the brain: Old findings and current issues

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