Reduced meal frequency alleviates high-fat diet-induced lipid accumulation and inflammation in adipose tissue of pigs under the circumstance of fixed feed allowance

Yan, Honglin; Cao, S.C.; Li, Yan; Zhang, Hongfu; Liu, Jingbo

doi:10.1007/s00394-019-01928-3

Cited by 35 publications

(22 citation statements)

References 40 publications

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“…For serum biochemical parameters, total protein ( TP ), albumin ( ALB ), IgG, IgA, and IgM, were analyzed using an automatic biochemical analyzer (Hitachi 7180, Japan). For serum antioxidant index, the levels of superoxide dismutase ( SOD ), malondialdehyde ( MDA ), glutathione peroxidase ( GSH-Px ) were analyzed using ELISA method (Jiancheng Biotechnology Institute, Nanjing, China) following the kit instructions ( Yan et al., 2019 ).…”

Section: Methodsmentioning

confidence: 99%

Effects of feeding diets with processed Moringa oleifera stem meal on growth and laying performance, and immunological and antioxidant activities in laying ducks

Yang

Zhou

et al. 2020

Poultry Science

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This study was conducted to determine the effect of Moringa oleifera stem ( MOS ) meal in ducks. A total of 225 ducklings at 1 D of age were randomly assigned to 3 dietary treatment groups with 3 replicates of 25 each. The growth experiment lasted 63 D . The egg experiment started from 23 to 27 wk of age. Ducks were randomly divided into 3 treatment groups with 3 replications of 15 each. The following dietary treatments were applied: 1) Control ( CON ), basal diet + 0% MOS meal; 2) basal diet + 2% MOS meal; 3) basal diet + 4% MOS meal. During 0 to 4 wk of age, ducks fed 2% MOS diet showed significantly increase in average daily feed intake ( ADFI ) and average daily gain ( ADG ; P < 0.05) and ducks fed 4% MOS diet had a significant improvement in feed conversion rate ( FCR ; P < 0.05). However, ADFI, ADG, and FCR were not affected significantly during 5 to 9 wk of age ( P > 0.05). In egg production experiment, ADFI, average egg weight, laying rate, and FCR showed significant increase in 4% MOS diets ( P < 0.05). Laying ducks fed 4% MOS diet had a higher egg shape index, whereas a lower yolk color compared with CON ( P < 0.05). The proportion of broken shell eggs were zero in experimental diets, whereas 3% of which occurred in CON ( P < 0.05). However, no significant effects in proportion of soft shell eggs, proportion of abnormal-shape eggs, albumen height, haugh unit, and eggshell thickness were observed among all treatments ( P > 0.05). For serum biochemical parameters, total protein and albumin were increased in MOS diets during 0 to 4 wk of age, but decreased during 5 to 9 wk of age. For serum antioxidant index, superoxide dismutase and glutathione peroxidase values were increased whereas malondialdehyde values were decreased in MOS diets from 0 to 9 wk of age. The results suggest that MOS positively affects early growth performance and laying performane of duckling but partially affects egg quality. The antioxidative activity and immunological index may be improved.

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Section: Methodsmentioning

confidence: 99%

Effects of feeding diets with processed Moringa oleifera stem meal on growth and laying performance, and immunological and antioxidant activities in laying ducks

Yang

Zhou

et al. 2020

Poultry Science

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“…The protein expression of ZO1, occludin, claudin1, HO1, and GPx in jejunal mucosa were further detected by Western blotting, performed as previously described [28,29], to confirm whether the transcriptional regulation also occurred at the translation level. Briefly, the total protein extractions from jejunal mucosa were harvested in lysis buffer (Beyotime Biotechnology, Jiangsu, China) supplemented with a complete protease inhibitor cocktail (Pierce Chemical, Rockford, IL, USA) and cleared by centrifugation at 12,000× g for 30 min at 4 °C.…”

Section: Methodsmentioning

confidence: 99%

L-Tryptophan Enhances Intestinal Integrity in Diquat-Challenged Piglets Associated with Improvement of Redox Status and Mitochondrial Function

Liu

Zhang

et al. 2019

Animals

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Tryptophan (Trp) supplementation has been shown to improve growth performance and enhance intestinal integrity in piglets. However, the effects of dietary Trp supplementation on the intestinal barrier function in piglets exposed to oxidative stress remain unknown. This study was conducted to evaluate whether dietary Trp supplementation can attenuate intestinal injury, oxidative stress, and mitochondrial dysfunction of piglets caused by diquat injection. Thirty-two piglets at 25 days of age were randomly allocated to four groups: (1) the non-challenged control; (2) diquat-challenged control; (3) 0.15% Trp-supplemented diet + diquat; (4) 0.30% Trp supplemented diet + diquat. On day seven, the piglets were injected intraperitoneally with sterilized saline or diquat (10 mg/kg body weight). The experiment lasted 21 days. Dietary supplementation with 0.15% Trp improved growth performance of diquat-challenged piglets from day 7 to 21. Diquat induced an increased intestinal permeability, impaired antioxidant capacity, and mitochondrial dysfunction. Although dietary supplementation with 0.15% Trp ameliorated these negative effects induced by diquat challenge that showed decreasing permeability of 4 kDa fluorescein isothiocyanate dextran, increasing antioxidant indexes, and enhancing mitochondrial biogenesis. Results indicated that dietary supplementation with 0.15% Trp enhanced intestinal integrity, restored the redox status, and improved the mitochondrial function of piglets challenged with diquat.

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“…accumulation and in ammation in adipose tissue in pigs [12,19]. In this study, we tested the hypothesis that whether less MF could in uence both nutrient utilization and reproductive process of replacement gilts, and the current ndings revealed that less meal frequency increased nutrient utilization, promoted the secretion of luteinizing hormones, and improved ovarian follicular development in gilts.…”

Section: Effects Of Meal Frequency On the Secretion Of Luteinizing Homentioning

confidence: 91%

“…This eating pattern encourages the gilts extending the period of daily nutrient intake and thereby shortening the fasting period [1]. However, growing evidence revealed that this free eating pattern has been associated with a negative effect on growth, in ammation of adipose tissues and systemic health in growing pigs [12,19]. In this study, gilts were fed either with one, two, or six meals per day, but the eating windows of 3 hours were allowed for three dietary treatment groups, which eliminate the differences of energy expenditure (such as heat increment) induced by variations of feeding duration.…”

Section: Effects Of Meal Frequency On the Secretion Of Luteinizing Homentioning

confidence: 99%

Beneficial Effects of Decreased Meal Frequency on Nutrient Utilization, Secretion of Luteinizing Hormone and Ovarian Follicular Development in Gilts

Hua

Zhao

Mao

et al. 2020

Preprint

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Background: The replacement gilts are typically fed ad libitum, whereas emerging evidence in human and rodent studies revealed that time-restricted access to food had health benefits. The objective of this study was to investigate the effect of meal frequency on metabolic status and ovarian follicular development in gilts.Methods: A total of 36 gilts (Landrace × Yorkshire) at age of 150 (±3) d and bodyweight at 77.6 (±3.8) kg were randomly allocated into one of three meal frequencies (n = 12) to feed one meal (T1); two meals (T2), or six meals per day (T6) for a consecutive 14 weeks. The effect of meal frequency on growth preference, nutrient utilization, gut microbial metabolite short-chain fatty acids production at a 3-h interval, dynamics of metabolic status after a meal test, reproductive hormone secretions, and ovarian follicular development were measured in gilts.Results: Gilts in T1 group had greater average daily gain (+48 g/d, P < 0.05) and bodyweight (+4.9kg, P < 0.05) than T6 gilts. The apparent digestibilities of dry matter, crude protein, ether extract, ash and gross energy were not affected by meal frequency, except for a greater NDF digestibility in T1 gilts than T6 gilts (P < 0.05). Nitrogen balance trail reveal that the T1 gilts had lower urine excretion of nitrogen (-8.17 g/d, P < 0.05) and had a greater nitrogen retention (+9.81 g/d, P < 0.05), resulting in greater nitrogen utilization compared with T6 gilts. The time-course dynamics of glucose, α-amino nitrogen, urea, lactate, and insulin levels in serum revealed a greater utilization of nutrients after a meal test in T1 gilts than T2 or T6 gilts. The T1 gilts showed greater acetate content in feces compared with the other two groups (P < 0.05). The age, bodyweight and backfat thickness at first puberty of gilts were not affected by meal frequency, but gilts in T1 group had greater serum levels of luteinizing hormone and 17β-estradiol, a larger number of growing follicles and corpora lutea, and higher mRNA expression levels of genes related to follicular development on the 18th day of the 3rd estrus cycle.Conclusions: The current findings revealed unexpected benefits of meal frequency at one meal per day on the nutrient utilizations and reproductive function for replacement gilts, thus providing new insights into the nutritional strategy for replacement gilts, as well as the dietary pattern for other mammals, such as human.

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Reduced meal frequency alleviates high-fat diet-induced lipid accumulation and inflammation in adipose tissue of pigs under the circumstance of fixed feed allowance

Cited by 35 publications

References 40 publications

Effects of feeding diets with processed Moringa oleifera stem meal on growth and laying performance, and immunological and antioxidant activities in laying ducks

Effects of feeding diets with processed Moringa oleifera stem meal on growth and laying performance, and immunological and antioxidant activities in laying ducks

L-Tryptophan Enhances Intestinal Integrity in Diquat-Challenged Piglets Associated with Improvement of Redox Status and Mitochondrial Function

Beneficial Effects of Decreased Meal Frequency on Nutrient Utilization, Secretion of Luteinizing Hormone and Ovarian Follicular Development in Gilts

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