Reduced Maladaptive Behavior and Improved Social Function in a Child with PDD-NOS Treated with Progesterone

Gbadebo, Olufowobi S.

doi:10.3121/cmr.2010.942

Cited by 1 publication

(1 citation statement)

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“…Thus, if we assume an implication of progesterone in the overall emotion processing, the significant correlations between this steroid hormone and cerebral activations during affective task are not unexpected. What remains surprising, however, is that there was no association between progesterone and emotional processing in either healthy or schizophrenia women, despite progesterone's role in mood regulation of female subjects (in both human and animal studies) [ 4 , 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Progesterone and Cerebral Function during Emotion Processing in Men and Women with Schizophrenia

Champagne

Lakis

Bourque

et al. 2012

Schizophrenia Research and Treatment

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Schizophrenia has been associated with disturbed levels of sex-steroid hormones, including estrogen and testosterone. In the present study we have examined the implication of a less studied hormone progesterone. Forty-three patients with schizophrenia (21 women) and 43 control participants (21 women) underwent functional MRI while viewing emotionally positive, negative, and neutral images. Blood samples were taken prior to the scanning session to evaluate progesterone levels. Simple regression analyses between levels of progesterone and brain activations associated with emotion processing were performed using SPM5. A positive correlation was found between progesterone levels and brain activations during processing of emotionally charged images in both healthy and schizophrenia men, but no significant relationship was revealed in women. These preliminary results indicate that progesterone is significantly associated with brain activations during processing of positive and negative affect in healthy and schizophrenia men, but not in women. Further investigation is warranted.

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Section: Discussionmentioning

confidence: 99%