Reduced longitudinal cardiac strain in asthma patients

Tuleta, Izabela; Eckstein, Nicolas; Aurich, Florian; Nickenig, Georg; Schaefer, Christian; Skowasch, Dirk; Schueler, Robert

doi:10.1080/02770903.2018.1466311

Cited by 8 publications

(6 citation statements)

References 35 publications

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“…These findings appear to be consistent with recent studies in adult population. In line with these observations, previous studies have reported various cardiac abnormalities in asthmatic patients such as an increase in indexed LV mass ( Sun et al, 2017 ) and a significantly reduced left and right ventricular strain values in severe and mild-to-moderate asthma ( Tulet et al, 2019 ). More recently, the BADA study-ECO has provided further evidence supporting the existence of significant subclinical cardiac involvement in asthma ( Di Raimondo et al, 2022 ).…”

Section: Introductionsupporting

confidence: 69%

Cardio-respiratory interactions in acute asthma

Caplan,

Hamzaoui

2023

Front. Physiol.

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Asthma encompasses of respiratory symptoms that occur intermittently and with varying intensity accompanied by reversible expiratory airflow limitation. In acute exacerbations, it can be life-threatening due to its impact on ventilatory mechanics. Moreover, asthma has significant effects on the cardiovascular system, primarily through heart-lung interaction-based mechanisms. Dynamic hyperinflation and increased work of breathing caused by a sharp drop in pleural pressure, can affect cardiac function and cardiac output through different mechanisms. These mechanisms include an abrupt increase in venous return, elevated right ventricular afterload and interdependence between the left and right ventricle. Additionally, Pulsus paradoxus, which reflects the maximum consequences of this heart lung interaction when intrathoracic pressure swings are exaggerated, may serve as a convenient bedside tool to assess the severity of acute asthma acute exacerbation and its response to therapy.

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Section: Introductionsupporting

confidence: 69%

Cardio-respiratory interactions in acute asthma

Caplan,

Hamzaoui

2023

Front. Physiol.

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“…In our study, the LV systolic function was preserved in the patient group. Ozdemir et al reported similar findings regarding EF and S′ velocity at the mitral annulus, wh ile Tuleta et al reported diminished LV longitudinal strain in patients with severe and mild to moderate asthma. This is in contrast to our patients who mostly had mild asthma.…”

Section: Discussionmentioning

confidence: 69%

Evaluation of cardiac function in pediatric patients with mild to moderate bronchial asthma in the era of cardiac strain imaging

Abdelmohsen

Mohamed

Mohsen

et al. 2019

Pediatric Pulmonology

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Objective Bronchial asthma is a common chronic inflammatory airway disease, which may be associated with pulmonary hypertension and cardiac dysfunction. The aim of this study was to evaluate the ability of 2D‐speckle tracking echocardiography (2D‐STE) and tissue doppler imaging (TDI) to detect subtle cardiac dysfunction in pediatric patients with mild to moderate bronchial asthma. Methodology The study included 30 children with mild to moderate bronchial asthma and 27 age‐matched healthy controls. Both groups underwent pulmonary function tests, TDI and 2D‐STE. Myocardial performance index (MPI), S′, E′, A′ velocities, global strain of left ventricle (LV), right ventricle (RV), and right atrium (RA) were measured. Results RV diastolic function was impaired in the patient group, as the tricuspid E′ velocity was significantly lower in the patients when compared with the controls (16 [14‐17] vs 16 [17‐19] cm/s, P = .044), while the RV‐MPI was significantly higher in patients when compared to controls (0.30 [0.27‐0.36] vs 0.30 [0.30‐0.30], P = .001). The global RV longitudinal strain, RA strain, and LV strain did not show significant differences between the test and the control groups. RV systolic parameters and LV systolic and diastolic parameters did not differ significantly between the two groups. Conclusion Pediatric patients with mild to moderate bronchial asthma may have early RV diastolic dysfunction with preserved other cardiac functions.

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“…In the current study, LV function was preserved in the asthmatic group by conventional and speckle tracking imaging. Abdelmohsen et al 6 reported similar results, while Tuleta et al 11 reported diminished LV GLS in moderate to severe asthma.…”

Section: Discussionmentioning

confidence: 81%

Can speckle tracking of right ventricle add value for evaluation of asthma severity in children?

et al. 2023

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Objective: To investigate myocardial deformation by tracking speckles along with evaluation of cardiac function using conventional and tissue Doppler imaging.Method: The case-control study was conducted at Kafrelsheikh University Hospital, Egypt, from September 2019 to May 2022, and comprised asthmatic children and healthy controls matched for age and gender. After taking family history of asthma, assessments were made for bronchial asthma treatment and severity. Clinical examination and pulmonary function tests were performed along with tissue Doppler imaging and speckle tracking. Global left ventricular and right ventricular strains were measured. Data was analysed using SPSS 22.Results: Of the 120 subjects, 60(50%) were cases; 33(55%) males and 27(45%) females with mean age 9.4±2.91 years. The remaining 60(50%) were controls; 34(56.7%) males and 26(43.3%) females with mean age 9.7±2.99 years (p>0.05). Among the cases, 36(60%) had moderate severity and 24(40%) had mild asthma. Family history was positive in 11(18.3%) cases and negative in 49(81.7%). There was no significant difference in terms of conventional echocardiography between the groups (p>0.05). There was impairment in right ventricular diastolic function in the cases, with lateral tricuspid E` velocity significantly lower (p<0.05) and isovolumetric relaxation time significantly higher than the controls (p=0.001). There was impairment of systolic function of the right ventricle in the cases compared tothe controls (p=0.001). Right ventricular peak longitudinal systolic stress cut-off value distinguishing the controls from the cases was -20.4 with sensitivity 85% and specificity 63%. The cut-off value distinguishing mild from moderate asthmatic cases was -19.8 with sensitivity 83% and specificity 91%.Conclusion: Speckle tracking echocardiography could detect very early subtle right ventricular systolic dysfunction. Right ventricle dysfunction worsened with the severity of asthma.Keywords: Hypertension, Pulmonary, Echocardiography, Respiratory, Asthma, Hypoxia.

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Reduced longitudinal cardiac strain in asthma patients

Abstract: Allergic asthma, especially severe asthma is associated with subclinical impaired left and right ventricular function as determined by speckle-tracking analysis.

Cited by 8 publications

References 35 publications

Cardio-respiratory interactions in acute asthma

Cardio-respiratory interactions in acute asthma

Evaluation of cardiac function in pediatric patients with mild to moderate bronchial asthma in the era of cardiac strain imaging

Can speckle tracking of right ventricle add value for evaluation of asthma severity in children?

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