Reduced levels of adiponectin in sleep apnea syndrome

Masserini, Benedetta; Morpurgo, Paola S.; Donadio, F; Baldessari, Chiara; Bossi, R.; Beck‐Peccoz, Paolo; Orsi, Emanuela

doi:10.1007/bf03344179

Cited by 61 publications

(40 citation statements)

References 42 publications

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“…It has been suggested that low serum adiponectin levels were tightly associated with increased risk of atherosclerosis and myocardial infarction [32,33]. Previous data from observational studies indicated that OSA was independently associated with adiponectin levels [6][7][8]. A cross-sectional analysis of 86 adult male patients suspected for OSA showed that serum adiponectin levels were significantly lower in the OSA group than in the control.…”

Section: Discussionmentioning

confidence: 95%

“…It has been suggested that reduced serum adiponectin levels could partly explain increased cardiovascular disease in OSA patients. Previous studies showed that OSA was associated with significant decrease in serum adiponectin levels [6][7][8].…”

Section: Introductionmentioning

confidence: 93%

“…One of them was randomized clinical trial (RCT) [19], the remaining studies were observational [20][21][22][23][24][25][26][27][28][29]. One study [27] reported results separately for obese group and non-obese group.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Effect of Continuous Positive Airway Pressure on Adiponectin in Patients With Obstructive Sleep Apnea: A Meta-analysis

Chen

Lin

Liu

2016

Chest

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ObjectiveObstructive sleep apnea (OSA) has been suggested to be associated with low levels of adiponectin. Continuous positive airway pressure (CPAP) is the gold standard treatment for OSA; however, previous studies assessing the effect of CPAP on adiponectin in patients with OSA yielded conflicting results. The present meta-analysis was performed to determine whether CPAP therapy could increase adiponectin levels. MethodsTwo reviewers independently searched PubMed, Cochrane library, Embase and Web of Science before February 2015. Information on characteristics of subjects, study design and pre-and post-CPAP treatment of serum adiponectin was extracted for analysis. Standardized mean difference (SMD) was used to analyze the summary estimates for CPAP therapy. ResultsEleven studies involving 240 patients were included in this meta-analysis, including ten observational studies and one randomized controlled study. The meta-analysis showed that there was no change of adiponectin levels before and after CPAP treatment in OSA patients (SMD = 0.059, 95% confidence interval (CI) = −0.250 to 0.368, z = 0.37, p = 0.710). Subgroup analyses indicated that the results were not affected by age, baseline body mass index, severity of OSA, CPAP therapy duration, sample size and racial differences.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 93%

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Effect of Continuous Positive Airway Pressure on Adiponectin in Patients With Obstructive Sleep Apnea: A Meta-analysis

Chen

Lin

Liu

2016

Chest

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“…Several other studies have demonstrated lower levels of APN in OSAS patients and subsequent improvement following CPAP therapy [104][105][106][107][108][109][110]. However, not all studies have shown an association between OSAS and APN [111][112][113][114][115].…”

Section: Clinical Studiesmentioning

confidence: 99%

Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation

Garvey

Taylor²,

McNicholas

2009

European Respiratory Journal

312

225

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There is increasing evidence that intermittent hypoxia plays a role in the development of cardiovascular risk in obstructive sleep apnoea syndrome (OSAS) through the activation of inflammatory pathways. The development of translational models of intermittent hypoxia has allowed investigation of its role in the activation of inflammatory mechanisms and promotion of cardiovascular disease in OSAS. There are noticeable differences in the response to intermittent hypoxia between body tissues but the hypoxia-sensitive transcription factors hypoxia-inducible factor-1 and nuclear factor-kB appear to play a key role in mediating the inflammatory and cardiovascular consequences of OSAS. Expanding our understanding of these pathways, the cross-talk between them and the activation of inflammatory mechanisms by intermittent hypoxia in OSAS will provide new avenues of therapeutic opportunity for the disease.

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“…OSAS has independently been associated with reduced levels of adiponectin (Masserini et al, 2006;Zhang et al, 2006;Carneiro et al, 2009) which may favour cardiovascular disease development. The recurrent hypoxia-reoxygenation attacks in OSAS patients may activate oxidative stress and lead to low levels of adiponectin (Vatansever et al, 2010).…”

Section: Obesitymentioning

confidence: 99%

Obstructive Sleep Apnoea Syndrome as a Systemic Low-Grade Inflammatory Disorder

Zamarrón¹,

Morete²,

Campo³

2012

Cardiovascular Risk Factors

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Reduced levels of adiponectin in sleep apnea syndrome

Abstract: OSAS is associated with reduced levels of adiponectin independently of insulin-resistance and BMI. These low adiponectin levels may contribute to the increased mortality seen in such patients.

Cited by 61 publications

References 42 publications

Effect of Continuous Positive Airway Pressure on Adiponectin in Patients With Obstructive Sleep Apnea: A Meta-analysis

Effect of Continuous Positive Airway Pressure on Adiponectin in Patients With Obstructive Sleep Apnea: A Meta-analysis

Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation

Obstructive Sleep Apnoea Syndrome as a Systemic Low-Grade Inflammatory Disorder

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