2009
DOI: 10.1016/j.placenta.2009.04.010
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Reduced l-Arginine Transport and Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells from Intrauterine Growth Restriction Pregnancies is Not Further Altered by Hypoxia

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Cited by 37 publications
(36 citation statements)
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“…Alterations in the synthesis and/or biological actions of NO have been related to abnormal blood flow in disorders of pregnancy that present as different entities but appear to share a common origin: the presence of placental endothelial dysfunction. This is the case of gestational diabetes [8,13], intrauterine growth retardation [14,15] and preeclampsia [10], which is the focus of this article.…”
Section: Endothelial Dysfunction In the Placenta And Its Consequencesmentioning
confidence: 99%
“…Alterations in the synthesis and/or biological actions of NO have been related to abnormal blood flow in disorders of pregnancy that present as different entities but appear to share a common origin: the presence of placental endothelial dysfunction. This is the case of gestational diabetes [8,13], intrauterine growth retardation [14,15] and preeclampsia [10], which is the focus of this article.…”
Section: Endothelial Dysfunction In the Placenta And Its Consequencesmentioning
confidence: 99%
“…Contrarily, we did not find an A 2B AR-mediated VEGF expression in preeclampsia, whereas it was evidenced in cell from normal pregnancy. Apparent discrepancy may be related to experimental condition, since in the Feokstitov's report [22] they use a HUVEC cell line, rather than primary culture as we reported; and hypoxia was defined as 4.6% oxygen, which is considered normoxia for primary culture of HUVEC [58]. …”
Section: Discussionmentioning
confidence: 99%
“…RNA Interference-Small interfering RNA (siRNA) from Sigma was synthesized using previously published and validated sequences for eNOS (30), MEK1 (31), MEK2 (31), and JNK1/2 (32). Sequences (sense) are as follows: eNOS, 5Ј-GGU-CUGCACAGGAAAUGUU(dT)(dT)-3Ј; MEK1, 5Ј-AAGUC-CUGAAGAAAGCUGGAA(dT)(dT)-3Ј; MEK2, 5Ј-AAGGU-CGGCGAACUCAAAGAC(dT)(dT)-3Ј; and JNK1/2, 5Ј-TGA-AAGAATGTCCTACCTT(dT)(dT)-3Ј.…”
Section: Methodsmentioning
confidence: 99%