Reduced interhemispheric structural connectivity between anterior cingulate cortices in borderline personality disorder

Rüsch, Nicolas; Bracht, Tobias; Kreher, Björn W.; Schnell, Susanne; Glauche, Volkmar; Il’yasov, K. A.; Ebert, Dieter; Lieb, Klaus; Hennig, Jürgen; Saur, Dorothee; Elst, Ludger Tebartz van

doi:10.1016/j.pscychresns.2009.08.004

Cited by 43 publications

(31 citation statements)

References 27 publications

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“…This result suggests a possible alteration in interhemispheric structural connectivity in prefrontal regions, which is in congruence with several previous studies in BPD (27,52) (but also see Zanetti et al (53) for contradictory evidence). Fibers connecting orbitofrontal and ventral medial prefrontal cortex pass through the genu of the corpus callosum (54).…”

Section: Discussionsupporting

confidence: 93%

“…From the structural point of view, reported white matter frontal abnormalities agree with some of the previous studies (25)(26)(27), but the observed bilateral increases in MD, mainly in gray matter, are new. Changes in MD have been previously related to gray matter changes (42) suggesting that the increases in MD in our study are probably linked to reduction in gray matter volumes in the same areas.…”

Section: Discussionsupporting

confidence: 89%

“…However, apart from weak evidence of orbitofrontal white matter deterioration in BPD (25)(26)(27), results with this modality are still scarce. Alternatively, resting-state functional MRI may be used to quantify the amplitude of blood oxygen level-dependent fluctuations, which are usually restricted to the low frequencies (e.g., .01-.1 Hz) and are commonly known as analyses of amplitude of low-frequency fluctuations (ALFF) (28).…”

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confidence: 99%

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Converging Medial Frontal Resting State and Diffusion-Based Abnormalities in Borderline Personality Disorder

Salvador

Vega

Pascual

et al. 2016

Biological Psychiatry

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BACKGROUND: The psychological profile of patients with borderline personality disorder (BPD), with impulsivity and emotional dysregulation as core symptoms, has guided the search for abnormalities in specific brain areas such as the hippocampal-amygdala complex and the frontomedial cortex. However, whole-brain imaging studies so far have delivered highly heterogeneous results involving different brain locations. METHODS: Functional resting-state and diffusion magnetic resonance imaging data were acquired in patients with BPD and in an equal number of matched control subjects (n 5 60 for resting and n 5 43 for diffusion). While mean diffusivity and fractional anisotropy brain images were generated from diffusion data, amplitude of low-frequency fluctuations and global brain connectivity images were used for the first time to evaluate BPD-related brain abnormalities from resting functional acquisitions. RESULTS: Whole-brain analyses using a p 5 .05 corrected threshold showed a convergence of alterations in BPD patients in genual and perigenual structures, with frontal white matter fractional anisotropy abnormalities partially encircling areas of increased mean diffusivity and global brain connectivity. Additionally, a cluster of enlarged amplitude of low-frequency fluctuations (high resting activity) was found involving part of the left hippocampus and amygdala. In turn, this cluster showed increased resting functional connectivity with the anterior cingulate. CONCLUSIONS: With a multimodal approach and without using a priori selected regions, we prove that structural and functional abnormality in BPD involves both temporolimbic and frontomedial structures as well as their connectivity. These structures have been previously related to behavioral and clinical symptoms in patients with BPD.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 99%

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Converging Medial Frontal Resting State and Diffusion-Based Abnormalities in Borderline Personality Disorder

Salvador

Vega

Pascual

et al. 2016

Biological Psychiatry

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“…Findings from neuroimaging studies of psychological processes and psychiatric conditions suggest that elucidation of interhemispheric connectivity in pain processing will likely further our understanding of the neural mechanisms involved (Anderson et al, 2011;Bloom and Hynd, 2005;Hofman and Schutter, 2009;Rüsch et al, 2010;Stephan et al, 2007;Thiruvady et al, 2007;Voineskos et al, 2010;Xu et al, 2013). Likewise, Kaller et al (2015), indicated that structural, transcallosal DLPFC pathways appear to maintain hemispheric functional asymmetries.…”

Section: Introductionmentioning

confidence: 99%

Interhemispheric Dorsolateral Prefrontal Cortex Connectivity is Associated with Individual Differences in Pain Sensitivity in Healthy Controls

et al. 2016

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The dorsolateral prefrontal cortex (DLPFC) is implicated in pain modulation through multiple psychological processes. Recent noninvasive brain stimulation studies suggest that interhemispheric DLPFC connectivity influences pain tolerance and discomfort by altering interhemispheric inhibition. The structure and role of interhemispheric DLPFC connectivity in pain processing have not been investigated. The present study used dynamic causal modeling (DCM) for fMRI to investigate transcallosal DLPFC connectivity during painful stimulation in healthy volunteers. DCM parameters were used to predict individual differences in sensitivity to noxious heat stimuli. Bayesian model selection results indicated that influences among the right DLPFC (rDLPFC) and left DLPFC (lDLPFC) are modulated during painful stimuli. Regression analyses revealed that greater rDLPFC/lDLPFC couplings were associated with higher suprathreshold pain temperatures. These results highlight the role of interhemispheric connectivity in pain modulation and support the preferential role of the right hemisphere in pain processing. Knowledge of these mechanisms may improve understanding of abnormal pain modulation in chronic pain populations.

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“…Among these, the orbitofrontal and dorsolateral prefrontal cortices play critical roles in regulatory processes, such as the downregulation of activation in the limbic and subcortical brain areas and in impulse control; the anterior cingulate cortex plays a role in emotion processing, salience detection, inhibitory control, and pain processing. DTI studies have also detected reduced white matter connectivity in the frontal cortex [131]. Sato et al [132] have shown that, among others, the orbitofrontal, rostral anterior cingulate, posterior cingulate, and middle temporal cortices are the most informative regions that can be used to discriminate borderline personality disorder patients from healthy volunteers.…”

Section: Borderline Personality Disordermentioning

confidence: 99%

Genetic and Neuroimaging Features of Personality Disorders: State of the Art

Fan

Shen

et al. 2016

Neurosci. Bull.

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Personality disorders often act as a common denominator for many psychiatric problems, and studies on personality disorders contribute to the etiopathology, diagnosis, and treatment of many mental disorders. In recent years, increasing evidence from various studies has shown distinctive features of personality disorders, and that from genetic and neuroimaging studies has been especially valuable. Genetic studies primarily target the genes encoding neurotransmitters and enzymes in the serotoninergic and dopaminergic systems, and neuroimaging studies mainly focus on the frontal and temporal lobes as well as the limbic-paralimbic system in patients with personality disorders. Although some studies have suffered due to unclear diagnoses of personality disorders and some have included few patients for a given personality disorder, great opportunities remain for investigators to launch new ideas and technologies in the field.

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Reduced interhemispheric structural connectivity between anterior cingulate cortices in borderline personality disorder

Cited by 43 publications

References 27 publications

Converging Medial Frontal Resting State and Diffusion-Based Abnormalities in Borderline Personality Disorder

Converging Medial Frontal Resting State and Diffusion-Based Abnormalities in Borderline Personality Disorder

Interhemispheric Dorsolateral Prefrontal Cortex Connectivity is Associated with Individual Differences in Pain Sensitivity in Healthy Controls

Genetic and Neuroimaging Features of Personality Disorders: State of the Art

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