Reduced Interhemispheric Functional Connectivity in Obsessive–Compulsive Disorder Patients

Deng, Ke; Qi, Tianfu; Xu, Jian; Jiang, Linlin; Zhang, Fengrui; Dai, Nan; Cheng, Yuqi; Xu, Xiufeng

doi:10.3389/fpsyt.2019.00418

Cited by 24 publications

(23 citation statements)

References 58 publications

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“…Decreased VMHC outside the CSTC circuits, such as the middle occipital, precentral, and postcentral gyri, in patients with OCD at rest in our study is similar to the results of Deng et al. ( 21 ). The occipital cortex is involved in the pathophysiology of OCD because of its connection with the CSTC circuits ( 4 , 36 ).…”

Section: Discussionsupporting

confidence: 92%

“…A recent meta-analysis discovered that patients with OCD showed hypoactivation in the bilateral thalamus and medial OFC during inhibitory control ( 35 ). Decreased VMHC values in the OFC and thalamus in patients with OCD at rest were also observed in other studies ( 21 , 22 ). The present and previous studies supported the disconnection between homotopic brain regions within the CSTC circuits in patients with OCD, which might lead to obstacles in the communication and integration of cognitive and emotional information in OCD ( 15 ).…”

Section: Discussionsupporting

confidence: 86%

“…In this study, we investigated interhemispheric FC at rest in a relatively large number of medication-free patients with OCD using the VMHC method. We hypothesized that patients with OCD would exhibit decreased VMHC within and outside the CSTC circuits based on previous studies ( 21 , 22 ). We further explored the correlations between altered VMHC values and clinical variables in patients with OCD.…”

Section: Introductionmentioning

confidence: 99%

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Decreased Resting-State Interhemispheric Functional Connectivity in Medication-Free Obsessive-Compulsive Disorder

Jia

Chen

et al. 2020

Front. Psychiatry

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Objective Decreased homotopic connectivity of brain networks such as the cortico-striato-thalamo-cortical (CSTC) circuits may contribute to the pathophysiology of obsessive-compulsive disorder (OCD). However, little is known about interhemispheric functional connectivity (FC) at rest in OCD. In this study, the voxel-mirrored homotopic connectivity (VMHC) method was applied to explore interhemispheric coordination at rest in OCD. Methods Forty medication-free patients with OCD and 38 sex-, age-, and education level-matched healthy controls (HCs) underwent a resting-state functional magnetic resonance imaging. The VMHC and support vector machine (SVM) methods were used to analyze the data. Results Patients with OCD had remarkably decreased VMHC values in the orbitofrontal cortex, thalamus, middle occipital gyrus, and precentral and postcentral gyri compared with HCs. A combination of the VMHC values in the thalamus and postcentral gyrus could optimally distinguish patients with OCD from HCs. Conclusions Our findings highlight the contribution of decreased interhemispheric FC within and outside the CSTC circuits in OCD and provide evidence to the pathophysiology of OCD.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Decreased Resting-State Interhemispheric Functional Connectivity in Medication-Free Obsessive-Compulsive Disorder

Jia

Chen

et al. 2020

Front. Psychiatry

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“…The authors' research and other studies previously found decreased FC within the CSTC circuits at rest in OCD (Wang et al, 2018;Deng et al, 2019;Jia et al, 2020). Although these researchers found that FC strength seemed to exhibit functional asymmetry, they did not explore functional asymmetry of the interhemispheric and/or intra-hemispheric FC at rest in OCD.…”

Section: Discussionmentioning

confidence: 78%

Disrupted Asymmetry of Inter- and Intra-Hemispheric Functional Connectivity at Rest in Medication-Free Obsessive-Compulsive Disorder

Jia

Chen

et al. 2021

Front. Neurosci.

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Disrupted functional asymmetry of cerebral hemispheres may be altered in patients with obsessive-compulsive disorder (OCD). However, little is known about whether anomalous brain asymmetries originate from inter- and/or intra-hemispheric functional connectivity (FC) at rest in OCD. In this study, resting-state functional magnetic resonance imaging was applied to 40 medication-free patients with OCD and 38 gender-, age-, and education-matched healthy controls (HCs). Data were analyzed using the parameter of asymmetry (PAS) and support vector machine methods. Patients with OCD showed significantly increased PAS in the left posterior cingulate cortex, left precentral gyrus/postcentral gyrus, and right inferior occipital gyrus and decreased PAS in the left dorsolateral prefrontal cortex (DLPFC), bilateral middle cingulate cortex (MCC), left inferior parietal lobule, and left cerebellum Crus I. A negative correlation was found between decreased PAS in the left DLPFC and Yale–Brown Obsessive-compulsive Scale compulsive behavior scores in the patients. Furthermore, decreased PAS in the bilateral MCC could be used to distinguish OCD from HCs with a sensitivity of 87.50%, an accuracy of 88.46%, and a specificity of 89.47%. These results highlighted the contribution of disrupted asymmetry of intra-hemispheric FC within and outside the cortico-striato-thalamocortical circuits at rest in the pathophysiology of OCD, and reduced intra-hemispheric FC in the bilateral MCC may serve as a potential biomarker to classify individuals with OCD from HCs.

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“…Apart from structural abnormalities, functional studies also highlight the importance of trans‐callosal connectivity alterations in OCD. Adult patients with OCD have been reported to have decreased functional connectivity between the right ventral lateral prefrontal cortex and left insula (Chen et al., 2018) and decreased voxel‐mirrored homotopic connectivity in the precentral gyrus and orbitofrontal cortex (Deng et al., 2019). Additionally, increased functional frontal asymmetry in patients with OCD has been observed in electroencephalography studies (Perera et al., 2019).…”

Section: Discussionmentioning

confidence: 99%

Microstructural white matter abnormalities in pediatric and adult obsessive‐compulsive disorder: A systematic review and meta‐analysis

Zhao

Huang

et al. 2020

Brain and Behavior

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Objective To identify the most prominent and replicable fractional anisotropy (FA) alterations of white matter associated with obsessive‐compulsive disorder (OCD) in tract‐based spatial statistics (TBSS) studies. Methods We reviewed previous TBSS studies (n = 20) in OCD and performed a meta‐analysis (n = 16) of FA differences. Results No between‐group differences in FA were detected in the pooled meta‐analysis. However, reduced FA was identified in the genu and anterior body of corpus callosum (CC) in adult OCD. FA reductions in the anterior body of CC were associated with a later age of onset in adult patients with OCD. For pediatric OCD, decreased FA in earlier adolescence and increased FA in later adolescence were seemingly related to an altered trajectory of brain maturation. Conclusions Absent in the pooled sample but robust in adults, disrupted microstructural organization in the anterior part of CC indicates a bias of deficits toward connections in interhemispheric connections of rostral neocortical regions, which could lead to deficits of interhemispheric communication and thus contribute to cognitive and emotional deficits in adult OCD. The correlation between FA in the anterior body of CC and older illness onset suggests that patients with later adult onset of illness may represent a biologically distinct subgroup. For pediatric OCD, alterations in neurodevelopmental maturation may contribute to inconsistent patterns of FA alteration relative to controls during adolescence. While most studies of OCD have emphasized alterations of within hemisphere fronto‐striatal circuits, these results indicate that between hemisphere connectivity of this circuitry may also represent important pathophysiology of the illness.

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Reduced Interhemispheric Functional Connectivity in Obsessive–Compulsive Disorder Patients

Cited by 24 publications

References 58 publications

Decreased Resting-State Interhemispheric Functional Connectivity in Medication-Free Obsessive-Compulsive Disorder

Decreased Resting-State Interhemispheric Functional Connectivity in Medication-Free Obsessive-Compulsive Disorder

Disrupted Asymmetry of Inter- and Intra-Hemispheric Functional Connectivity at Rest in Medication-Free Obsessive-Compulsive Disorder

Microstructural white matter abnormalities in pediatric and adult obsessive‐compulsive disorder: A systematic review and meta‐analysis

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