Reduced Interhemispheric Connectivity in Childhood Autism Detected by Electroencephalographic Photic Driving Coherence

Лазарев, В. В.; Pontes, Adailton T.; Mitrofanov, Andrey; deAzevedo, Leonardo C.

doi:10.1007/s10803-013-1959-8

Cited by 31 publications

(39 citation statements)

References 39 publications

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“…In line with an emerging literature that consistently implicates cortical underconnectivity during various cognitive processes as a critical feature of ASD (e.g., Assaf et al, 2010; Damarla et al, 2010; Lazarev et al, 2013; Minshew & Keller, 2010), the findings from this study suggest that cortical underconnectivity may underlie joint attention impairments in ASD. This study also provides preliminary support for the current model of joint attention impairment of autism—one of a problematic integration between neural representations of self- and other-referenced information (Mundy et al, 2009, Mundy & Jarrold, 2010).…”

Section: Discussionsupporting

confidence: 88%

“…Altered cortical connectivity in ASD has been posited to result from atypical brain overgrowth and neural pruning during critical periods of experience-dependent neurodevelopment (see Courchesne et al, 2005a for a review). Although there is a substantial body of literature indicative of cortical under-connectivity in individuals with ASD during a resting state (e.g., Cherkassy, Kana, Keller, & Just, 2006; Coben, Clarke, Hudspeth, & Barry, 2008; Lazarev, Pontes, Mitrofanov, & deAzevedo, 2013), language processing (Jones et al, 2010; Just et al, 2004; Kana, Keller, Cherskassky, Minshew, & Just, 2006), working memory (Koshino et al, 2005, 2008), affective processing (Wicker et al, 2008), perceptual processing (Darmala et al, 2010; Villalobos, Mizuno, Dahl, Kemmotsu, & Muller, 2005), and executive functioning (Just et al, 2007), there is also evidence of cortical over-connectivity during rest, imitation, and memory performance (e.g., Lynch et al, 2013; Uddin et al, 2013; Shih et al, 2010; Noonan et al, 2009). Studies have also reported both increased and decreased cortical connectivity in individuals with ASD that appears to be mediated by the frequency of neural oscillations and distance between cortical networks (e.g., Kitzbichler et al, in press).…”

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confidence: 99%

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Brief Report: Reduced Temporal-Central EEG Alpha Coherence During Joint Attention Perception in Adolescents with Autism Spectrum Disorder

Jaime

McMahon

Davidson

et al. 2015

J Autism Dev Disord

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Although prior studies have demonstrated reduced resting state EEG coherence in adults with autism spectrum disorder (ASD), no studies have explored the nature of EEG coherence during joint attention. We examined the EEG coherence of the joint attention network in adolescents with and without ASD during congruent and incongruent joint attention perception and an eyes-open resting condition. Across conditions, adolescents with ASD showed reduced right hemisphere temporal–central alpha coherence compared to typically developing adolescents. Greater right temporal–central alpha coherence during joint attention was positively associated with social cognitive performance in typical development but not in ASD. These results suggest that, in addition to a resting state, EEG coherence during joint attention perception is reduced in ASD.

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Section: Discussionsupporting

confidence: 88%

mentioning

confidence: 99%

Brief Report: Reduced Temporal-Central EEG Alpha Coherence During Joint Attention Perception in Adolescents with Autism Spectrum Disorder

Jaime

McMahon

Davidson

et al. 2015

J Autism Dev Disord

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“…This weakness in inter-hemispheric synchronization could contribute to reduced integration of distributed cortical γ activity encoding sensory evidence. Similar inter-hemispheric synchronization differences have also been found in the β band in response to repetitive visual stimulation (Lazarev et al, 2015) and in low to moderate (<13 Hz) frequencies during picture identification (Catarino et al, 2013). Unfortunately, these inter-hemispheric studies did not establish the behavioral relevance of these differences.…”

Section: Oscillatory Organization Is Disrupted In Asdsupporting

confidence: 65%

Dysfunction of sensory oscillations in Autism Spectrum Disorder

Simon

Wallace

2016

Neuroscience & Biobehavioral Reviews

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Autism Spectrum Disorder (ASD) is a highly prevalent developmental disability characterized by deficits in social communication and interaction, restricted interests, and repetitive behaviors. Recently, anomalous sensory and perceptual function has gained an increased level of recognition as an important feature of ASD. A specific impairment in the ability to integrate information across brain networks has been proposed to contribute to these disruptions. A crucial mechanism for these integrative processes is the rhythmic synchronization of neuronal excitability across neural populations; collectively known as oscillations. In ASD there is believed to be a deficit in the ability to efficiently couple functional neural networks using these oscillations. This review discusses evidence for disruptions in oscillatory synchronization in ASD, and how disturbance of this neural mechanism contributes to alterations in sensory and perceptual function. The review also frames oscillatory data from the perspective of prevailing neurobiologically-inspired theories of ASD.

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“…This is particularly clear for the case of inter-hemispheric connections, for which a decrease in EEG/MEG functional connectivity has been reported in many studies [93,94,96,100,107,114,134]. A smaller number of studies report mixed long-range overconnectivity and underconnectivity [97] or increased long-range connectivity in infants [113] and adolescents [116,117], in adult rapid-eye movement (REM) sleep [108], and during a picture-naming task in adults [120].…”

Section: Resultsmentioning

confidence: 83%

Is functional brain connectivity atypical in autism? A systematic review of EEG and MEG studies

2017

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BackgroundAlthough it is well recognized that autism is associated with altered patterns of over- and under-connectivity, specifics are still a matter of debate. Little has been done so far to synthesize available literature using whole-brain electroencephalography (EEG) and magnetoencephalography (MEG) recordings.Objectives1) To systematically review the literature on EEG/MEG functional and effective connectivity in autism spectrum disorder (ASD), 2) to synthesize and critically appraise findings related with the hypothesis that ASD is characterized by long-range underconnectivity and local overconnectivity, and 3) to provide, based on the literature, an analysis of tentative factors that are likely to mediate association between ASD and atypical connectivity (e.g., development, topography, lateralization).MethodsLiterature reviews were done using PubMed and PsychInfo databases. Abstracts were screened, and only relevant articles were analyzed based on the objectives of this paper. Special attention was paid to the methodological characteristics that could have created variability in outcomes reported between studies.ResultsOur synthesis provides relatively strong support for long-range underconnectivity in ASD, whereas the status of local connectivity remains unclear. This observation was also mirrored by a similar relationship with lower frequencies being often associated with underconnectivity and higher frequencies being associated with both under- and over-connectivity. Putting together these observations, we propose that ASD is characterized by a general trend toward an under-expression of lower-band wide-spread integrative processes compensated by more focal, higher-frequency, locally specialized, and segregated processes. Further investigation is, however, needed to corroborate the conclusion and its generalizability across different tasks. Of note, abnormal lateralization in ASD, specifically an elevated left-over-right EEG and MEG functional connectivity ratio, has been also reported consistently across studies.ConclusionsThe large variability in study samples and methodology makes a systematic quantitative analysis (i.e. meta-analysis) of this body of research impossible. Nevertheless, a general trend supporting the hypothesis of long-range functional underconnectivity can be observed. Further research is necessary to more confidently determine the status of the hypothesis of short-range overconnectivity. Frequency-band specific patterns and their relationships with known symptoms of autism also need to be further clarified.

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Reduced Interhemispheric Connectivity in Childhood Autism Detected by Electroencephalographic Photic Driving Coherence

Cited by 31 publications

References 39 publications

Brief Report: Reduced Temporal-Central EEG Alpha Coherence During Joint Attention Perception in Adolescents with Autism Spectrum Disorder

Brief Report: Reduced Temporal-Central EEG Alpha Coherence During Joint Attention Perception in Adolescents with Autism Spectrum Disorder

Dysfunction of sensory oscillations in Autism Spectrum Disorder

Is functional brain connectivity atypical in autism? A systematic review of EEG and MEG studies

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