Reduced intensity conditioning allogeneic bone marrow transplantation following central nervous system (CNS) relapse of acute promyelocytic leukemia: Evidence for a graft‐versus‐leukemia effect in the CNS

Ostronoff, M; Domingues, Mariana; Ostronoff, Fabiana; Matias, C.; Florêncio, Rodrigo; Matias, Kleber; Maior, Ana Patricia Souto; Sucupira, Alexandre; Calixto, Rodolfo; Tagliari, C.

doi:10.1002/ajh.20616

Cited by 7 publications

(1 citation statement)

References 4 publications

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“…We chose to perform autologous SCT as a consolidation therapy on our relapsed patients because of the decreased morbidity and mortality associated with autologous transplant, and its efficacy demonstrated in adults 4, 6, 11. There may be some advantage of the graft versus APL effect obtained after allogeneic SCT as demonstrated by case reports of successful reduced intensity allogeneic transplants or second allogeneic transplants for APL 12, 13. Allogeneic transplant causes less TRM in children than adults, but it is still associated with significant complications of acute and chronic graft versus host disease, prolonged immunosuppression, and risk of late infections 14.…”

Section: Discussionmentioning

confidence: 99%

Mobilization of PML‐RARA negative blood stem cells and salvage with autologous peripheral blood stem cell transplantation in children with relapsed acute promyelocytic leukemia

Termuhlen

Klopfenstein

Olshefski

et al. 2008

Pediatric Blood & Cancer

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Section: Discussionmentioning

confidence: 99%

Mobilization of PML‐RARA negative blood stem cells and salvage with autologous peripheral blood stem cell transplantation in children with relapsed acute promyelocytic leukemia

Termuhlen

Klopfenstein

Olshefski

et al. 2008

Pediatric Blood & Cancer

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Unrelated cord blood transplantation for central nervous system relapse in high-risk childhood acute lymphoblastic leukemia

et al. 2013

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Few clinical studies have investigated the role of unrelated cord blood transplantation (CBT) for central nervous system (CNS) relapse of childhood acute lymphoblastic leukemia (ALL) patients with high-risk factors. The aim of this report is to identify the potential benefits of unrelated CBT in high-risk childhood ALL with CNS relapse who has been treated on CNS-directed treatment strategies. Eleven childhood ALL patients with CNS relapse who underwent unrelated CBT enrolled in our study between 2001 and 2011, and all of the patients had features associated with poor outcomes, such as high white blood cells at diagnosis, ph + chromosome, or a history of bone marrow relapse. All transplants were performed with myeloablative-conditioning therapy (BU/cyclophosphamide (CY2) or total body irradiation/CY) plus highly CNS-active agents (carmustine or high-dose cytarabine). All patients achieved neutrophil engraftment and platelet engraftment. A total of nine patients (81.8 %) developed pre-engraftment syndrome at a median of 7 days, and three patients developed acute graft-vs-host disease at a median of 21 days. The median follow-up after CBT was 28.5 months. The probability of overall survival at 9 years was 63.6 %, and no patient experienced a CNS relapse. Our experience suggests that unrelated CBT appears to be an effective treatment option for CNS relapse of childhood ALL patients associated with poor outcome features.

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Comparison of central nervous system relapse outcomes following haploidentical vs identical-sibling transplant for acute lymphoblastic leukemia

Chen

et al. 2020

Ann Hematol

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Reduced intensity conditioning allogeneic bone marrow transplantation following central nervous system (CNS) relapse of acute promyelocytic leukemia: Evidence for a graft‐versus‐leukemia effect in the CNS

Cited by 7 publications

References 4 publications

Mobilization of PML‐RARA negative blood stem cells and salvage with autologous peripheral blood stem cell transplantation in children with relapsed acute promyelocytic leukemia

Mobilization of PML‐RARA negative blood stem cells and salvage with autologous peripheral blood stem cell transplantation in children with relapsed acute promyelocytic leukemia

Unrelated cord blood transplantation for central nervous system relapse in high-risk childhood acute lymphoblastic leukemia

Comparison of central nervous system relapse outcomes following haploidentical vs identical-sibling transplant for acute lymphoblastic leukemia

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