Reduced insulin secretion in normoglycaemic patients with β‐thalassaemia major

Angelopoulos, Nicholas; Zervas, A.; Livadas, Sarantis; Adamopoulos, Iannis E.; Giannopoulos, Dimitrios; Goula, Anastasia; Tolis, G.

doi:10.1111/j.1464-5491.2006.01988.x

Cited by 35 publications

(25 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, insulin signaling in muscle is comparable to ϩ/b controls. These features were unexpected based on previous studies reporting impaired glucose metabolism in iron-loaded patients and animals (1,10,18,41). However, results from such studies have been inconsistent (2,15,23,38).…”

mentioning

confidence: 66%

Glucose metabolism in the Belgrade rat, a model of iron-loading anemia

Jia

Kim

Veuthey

et al. 2013

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

The iron-diabetes hypothesis proposes an association between iron overload and glucose metabolism that is supported by a number of epidemiological studies. The prevalence of type 2 diabetes in patients with hereditary hemochromatosis and iron-loading thalassemia supports this hypothesis. The Belgrade rat carries a mutation in the iron transporter divalent metal transporter 1 (DMT1) resulting in iron-loading anemia. In this study, we characterized the glycometabolic status of the Belgrade rat. Belgrade rats displayed normal glycemic control. Insulin signaling and secretion were not impaired, and pancreatic tissue did not incur damage despite high levels of nonheme iron. These findings suggest that loss of DMT1 protects against oxidative damage to the pancreas and helps to maintain insulin sensitivity despite iron overload. Belgrade rats had lower body weight but increased food consumption compared with heterozygous littermates. The unexpected energy balance was associated with increased urinary glucose output. Increased urinary excretion of electrolytes, including iron, was also observed. Histopathological evidence suggests that altered renal function is secondary to changes in kidney morphology, including glomerulosclerosis. Thus, loss of DMT1 appears to protect the pancreas from injury but damages the integrity of kidney structure and function.

show abstract

mentioning

confidence: 66%

Glucose metabolism in the Belgrade rat, a model of iron-loading anemia

Jia

Kim

Veuthey

et al. 2013

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

show abstract

“…Both insulin secretion capacity (HOMA-B) and insulin sensitivity (HOMA-IR) are known to be impaired in thalassemia major, even in apparently normoglycemic cases. 12 It is important, therefore, to correlate these pre-diabetic biochemical abnormalities with MRI studies. Our results showed that hemosiderosis of the pancreas, as measured by MRI T2*, could not be predicted by age or ferritin levels.…”

Section: Resultsmentioning

confidence: 99%

A T2* magnetic resonance imaging study of pancreatic iron overload in thalassemia major

Au¹,

Lam²,

Chu³

et al. 2008

Haematologica

View full text Add to dashboard Cite

We studied the utility of pancreatic magnetic resonance imaging (MRI) in 72 thalassemia major patients (21 diabetic, 51 normoglycemic). Diabetic patients were significantly older (p<0.0001) and had smaller pancreas volume (p<0.0001). The two groups were comparable for ferritin and MRI-T2* heart, liver and pancreas. Pancreatic T2* signals were abnormal in 80% of both groups, and correlated with heart T2*. In normoglycemic patients, cardiac T2* and log-pancreatic T2* values correlated with homeostatic model assessments HOMA-B (␤ cell reserve), HOMA-IR (insulin resistance) and fasting insulin/C-peptide levels. This suggested that improved chelation may improve ␤ cell reserve and prevent pancreatic atrophy.

show abstract

“…However, other studies report that a defect in β-cell insulin secretion (defective insulin secretion) resulting from toxic effects of iron deposition in the pancreas may precede the development of glucose intolerance [25,26] (Figure 2).…”

Section: Figure 2 Iron Load and Glycemic Abnormalities In Thalassemimentioning

confidence: 96%

Diabetes and Glucose Metabolism in Thalassemia Major: An Update

Sanctis¹,

Soliman

Elsedfy

et al. 2016

Expert Review of Hematology

View full text Add to dashboard Cite

In patients with TM, uncontrolled iron overload has serious clinical consequences with considerable morbidity and mortality. Complications include liver damage, cardiac disease and endocrine dysfunction. Diabetes is an important complication of TM. The mechanisms of abnormal glucose homeostasis are complex and multifactorial. This review updates the current knowledge about glycemic abnormalities in TM patients and directs the attention to an early diagnosis and proper management.

show abstract

Reduced insulin secretion in normoglycaemic patients with β‐thalassaemia major

Abstract: These results support the concept that impaired B-cell function, as reflected by a reduction in the insulin secretion index, is present in beta-thalassaemic patients with normoglycaemia before changes in oral glucose tolerance tests are apparent.

Cited by 35 publications

References 22 publications

Glucose metabolism in the Belgrade rat, a model of iron-loading anemia

Glucose metabolism in the Belgrade rat, a model of iron-loading anemia

A T2* magnetic resonance imaging study of pancreatic iron overload in thalassemia major

Diabetes and Glucose Metabolism in Thalassemia Major: An Update

Contact Info

Product

Resources

About